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Chlorine in PDB 1h5u: The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug

Enzymatic activity of The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug

All present enzymatic activity of The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug:
2.4.1.1;

Protein crystallography data

The structure of The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug, PDB code: 1h5u was solved by N.G.Oikonomakos, S.E.Zographos, V.T.Skamnaki, G.Archontis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 26.25 / 1.76
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 128.966, 128.966, 116.186, 90.00, 90.00, 90.00
R / Rfree (%) 21.1 / 23.5

Other elements in 1h5u:

The structure of The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug also contains other interesting chemical elements:

Fluorine (F) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug (pdb code 1h5u). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug, PDB code: 1h5u:

Chlorine binding site 1 out of 1 in 1h5u

Go back to Chlorine Binding Sites List in 1h5u
Chlorine binding site 1 out of 1 in the The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl920

b:27.2
occ:1.00
 CL1 A:CHI920 0.0 27.2 1.0
C1 A:CHI920 1.7 28.9 1.0
C6 A:CHI920 2.7 26.4 1.0
C2 A:CHI920 2.8 28.6 1.0
CG2 A:VAL64 3.5 26.0 1.0
CE3 A:TRP67 3.6 24.3 1.0
N A:VAL64 3.6 26.2 1.0
O A:ARG60 3.7 17.2 1.0
CG A:ARG60 3.7 17.2 1.0
CB A:LEU63 3.8 23.1 1.0
CZ3 A:TRP67 3.9 23.8 1.0
CA A:VAL64 3.9 24.5 1.0
C5 A:CHI920 4.0 28.9 1.0
C3 A:CHI920 4.1 28.6 1.0
C A:LEU63 4.2 23.7 1.0
CB A:VAL64 4.4 26.3 1.0
CG A:PRO229 4.4 17.5 1.0
CD A:ARG60 4.4 23.6 1.0
C4 A:CHI920 4.6 30.0 1.0
CD1 A:LEU63 4.6 23.3 1.0
CA A:LEU63 4.6 22.4 1.0
C A:ARG60 4.7 16.6 1.0
CD2 A:TRP67 4.7 23.4 1.0
O A:HOH2018 4.7 25.2 1.0
O A:LEU63 4.8 25.6 1.0
CG A:LEU63 4.8 26.8 1.0
NE A:ARG60 4.9 23.8 1.0
CB A:PRO229 4.9 17.8 1.0

Reference:

N.G.Oikonomakos, S.E.Zographos, V.T.Skamnaki, G.Archontis. The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose, and CP320626, A Potential Antidiabetic Drug Bioorg.Med.Chem. V. 10 1313 2002.
ISSN: ISSN 0968-0896
PubMed: 11886794
DOI: 10.1016/S0968-0896(01)00394-7
Page generated: Fri Jul 19 22:25:15 2024

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