Chlorine in PDB 1hyv: Hiv Integrase Core Domain Complexed with Tetraphenyl Arsonium

All present enzymatic activity of Hiv Integrase Core Domain Complexed with Tetraphenyl Arsonium:
2.7.7.49;

The structure of Hiv Integrase Core Domain Complexed with Tetraphenyl Arsonium, PDB code: 1hyv was solved by V.Molteni, J.Greenwald, D.Rhodes, Y.Hwang, W.Kwiatkowski, F.D.Bushman, J.S.Siegel, S.Choe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.70
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	72.010, 72.010, 65.600, 90.00, 90.00, 120.00
R / Rfree (%)	22.1 / 26.3

The structure of Hiv Integrase Core Domain Complexed with Tetraphenyl Arsonium also contains other interesting chemical elements:

Arsenic

(As)

3 atoms

The binding sites of Chlorine atom in the Hiv Integrase Core Domain Complexed with Tetraphenyl Arsonium (pdb code 1hyv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Hiv Integrase Core Domain Complexed with Tetraphenyl Arsonium, PDB code: 1hyv:

Chlorine binding site 1 out of 1 in the Hiv Integrase Core Domain Complexed with Tetraphenyl Arsonium


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Hiv Integrase Core Domain Complexed with Tetraphenyl Arsonium within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl303 b:52.4 occ:1.00 OG1 A:THR174 3.1 25.5 1.0 CD2 A:HIS171 3.4 44.0 1.0 N A:HIS171 3.4 34.7 1.0 C23 A:TTA304 3.5 80.8 1.0 N A:GLU170 3.5 37.0 1.0 CB A:THR174 3.7 23.8 1.0 CB A:GLU170 3.8 44.4 1.0 CG A:HIS171 3.9 41.0 1.0 CB A:HIS171 4.0 37.5 1.0 CA A:GLU170 4.1 38.7 1.0 C22 A:TTA304 4.1 80.8 1.0 CG2 A:THR174 4.1 25.1 1.0 CB A:ALA169 4.1 36.4 1.0 C A:GLU170 4.3 39.2 1.0 CA A:HIS171 4.3 34.4 1.0 C A:ALA169 4.3 35.7 1.0 C24 A:TTA304 4.4 80.2 1.0 CA A:ALA169 4.4 36.7 1.0 NE2 A:HIS171 4.4 45.2 1.0 O A:HIS171 4.8 27.3 1.0 O A:HOH313 4.8 32.9 1.0

V.Molteni, J.Greenwald, D.Rhodes, Y.Hwang, W.Kwiatkowski, F.D.Bushman, J.S.Siegel, S.Choe. Identification of A Small-Molecule Binding Site at the Dimer Interface of the Hiv Integrase Catalytic Domain. Acta Crystallogr.,Sect.D V. 57 536 2001.
ISSN: ISSN 0907-4449
PubMed: 11264582
DOI: 10.1107/S0907444901001652