Chlorine in PDB 1k01: Structural Basis For the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria

The structure of Structural Basis For the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria, PDB code: 1k01 was solved by F.Schluenzen, R.Zarivach, J.Harms, A.Bashan, A.Tocilj, R.Albrecht, A.Yonath, F.Franceschi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 3.50
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	171.100, 409.300, 696.900, 90.00, 90.00, 90.00
R / Rfree (%)	27.5 / 32.1

The structure of Structural Basis For the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria also contains other interesting chemical elements:

Magnesium

(Mg)

3 atoms

The binding sites of Chlorine atom in the Structural Basis For the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria (pdb code 1k01). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structural Basis For the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria, PDB code: 1k01:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structural Basis For the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structural Basis For the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2884 b:80.6 occ:1.00 CL1 A:CLM2884 0.0 80.6 1.0 C1 A:CLM2884 1.7 80.6 1.0 C2 A:CLM2884 2.7 80.6 1.0 CL2 A:CLM2884 2.8 80.6 1.0 O2 A:CLM2884 3.0 80.6 1.0 N2 A:CLM2884 3.8 80.6 1.0 O4 A:U2564 3.9 71.0 1.0 O2' A:A2430 4.0 72.2 1.0 N3 A:U2564 4.3 71.0 1.0 C4 A:U2564 4.6 71.0 1.0 C2' A:A2430 4.6 72.2 1.0 N6 A:A2581 4.7 61.8 1.0

Chlorine binding site 2 out of 2 in the Structural Basis For the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structural Basis For the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2884 b:80.6 occ:1.00 CL2 A:CLM2884 0.0 80.6 1.0 C1 A:CLM2884 1.8 80.6 1.0 C2' A:A2430 2.2 72.2 1.0 O2' A:A2430 2.3 72.2 1.0 C2 A:CLM2884 2.7 80.6 1.0 CL1 A:CLM2884 2.8 80.6 1.0 C1' A:A2430 3.2 72.2 1.0 O2 A:CLM2884 3.2 80.6 1.0 N2 A:CLM2884 3.5 80.6 1.0 C3' A:A2430 3.5 72.2 1.0 N3 A:A2430 3.5 73.2 1.0 N9 A:A2430 3.6 73.2 1.0 C4 A:A2430 3.7 73.2 1.0 O3' A:A2430 3.9 72.2 1.0 O5' A:C2431 4.3 68.1 1.0 O4' A:C2431 4.4 68.1 1.0 O4' A:A2430 4.4 72.2 1.0 C2 A:A2430 4.5 73.2 1.0 C8 A:A2430 4.6 73.2 1.0 C4' A:A2430 4.6 72.2 1.0 C5 A:A2430 4.7 73.2 1.0 C3 A:CLM2884 4.8 80.6 1.0 P A:C2431 4.9 68.1 1.0

F.Schlunzen, R.Zarivach, J.Harms, A.Bashan, A.Tocilj, R.Albrecht, A.Yonath, F.Franceschi. Structural Basis For the Interaction of Antibiotics with the Peptidyl Transferase Centre in Eubacteria. Nature V. 413 814 2001.
ISSN: ISSN 0028-0836
PubMed: 11677599
DOI: 10.1038/35101544