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Chlorine in PDB 1mox: Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha

Enzymatic activity of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha

All present enzymatic activity of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha:
2.7.1.112;

Protein crystallography data

The structure of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha, PDB code: 1mox was solved by T.P.J.Garrett, N.M.Mckern, M.Lou, T.C.Elleman, T.E.Adams, G.O.Lovrecz, H.-J.Zhu, F.Walker, M.J.Frenkel, P.A.Hoyne, R.N.Jorissen, E.C.Nice, A.W.Burgess, C.W.Ward, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.50
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 51.590, 198.710, 78.900, 90.00, 102.03, 90.00
R / Rfree (%) 23.7 / 28.9

Other elements in 1mox:

The structure of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha also contains other interesting chemical elements:

Cadmium (Cd) 11 atoms
Platinum (Pt) 7 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha (pdb code 1mox). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha, PDB code: 1mox:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 1mox

Go back to Chlorine Binding Sites List in 1mox
Chlorine binding site 1 out of 4 in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl736

b:47.5
occ:1.00
 CD A:CD721 2.4 46.6 1.0
OD1 A:ASP498 3.6 36.5 1.0
OE2 A:GLU495 3.7 47.6 1.0
CD A:PRO494 3.9 42.3 1.0
CD A:GLU495 4.0 44.1 1.0
OG A:SER423 4.0 36.7 1.0
CG A:PRO494 4.1 42.6 1.0
OD1 A:ASP392 4.1 48.7 1.0
CG2 A:THR391 4.2 46.8 1.0
CG A:GLU495 4.3 42.5 1.0
OE1 A:GLU495 4.5 41.9 1.0
CD A:CD730 4.6 54.0 1.0
CG A:ASP498 4.6 40.8 1.0
CG A:ASP392 4.8 46.4 1.0
OD2 A:ASP498 4.9 38.9 1.0
CB A:GLU495 4.9 42.2 1.0
CD A:CD722 4.9 71.1 1.0
N A:PRO494 4.9 44.5 1.0

Chlorine binding site 2 out of 4 in 1mox

Go back to Chlorine Binding Sites List in 1mox
Chlorine binding site 2 out of 4 in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl737

b:0.6
occ:1.00
 NZ A:LYS333 2.9 64.9 1.0
CD2 A:HIS334 2.9 64.5 1.0
O A:HOH744 2.9 78.1 1.0
CL A:CL739 2.9 83.9 1.0
CE A:LYS333 3.6 64.7 1.0
NE2 A:HIS334 3.6 65.0 1.0
OE2 A:GLU320 3.9 84.5 1.0
CG A:HIS334 4.1 64.0 1.0
CG A:LYS333 4.6 62.9 1.0
O A:THR330 4.7 45.9 1.0
CD A:LYS333 4.7 64.3 1.0
CD A:GLU320 4.7 85.6 1.0
CB A:HIS334 4.7 60.7 1.0
CE1 A:HIS334 4.9 63.9 1.0
CA A:ASN331 5.0 45.4 1.0

Chlorine binding site 3 out of 4 in 1mox

Go back to Chlorine Binding Sites List in 1mox
Chlorine binding site 3 out of 4 in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl739

b:83.9
occ:1.00
 OE2 A:GLU320 2.7 84.5 1.0
O A:HOH744 2.8 78.1 1.0
CL A:CL737 2.9 0.6 1.0
C8 A:NAG651 3.3 65.1 1.0
CB A:GLU320 3.5 82.2 1.0
CD A:GLU320 3.7 85.6 1.0
CG A:GLU320 4.0 84.2 1.0
O A:GLU320 4.3 82.6 1.0
CD2 A:HIS334 4.3 64.5 1.0
NE2 A:HIS334 4.6 65.0 1.0
CA A:GLU320 4.7 81.2 1.0
OE1 A:GLU320 4.7 86.1 1.0
C7 A:NAG651 4.7 66.7 1.0
C A:GLU320 4.8 81.3 1.0

Chlorine binding site 4 out of 4 in 1mox

Go back to Chlorine Binding Sites List in 1mox
Chlorine binding site 4 out of 4 in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl738

b:68.8
occ:1.00
 CD B:CD727 2.2 77.5 1.0
OE2 B:GLU35 3.2 59.2 1.0
CD B:GLU35 4.0 56.3 1.0
OE1 B:GLU35 4.1 58.6 1.0
O B:HOH817 4.3 56.7 1.0
NE2 B:GLN59 4.5 45.2 1.0

Reference:

T.P.J.Garrett, N.M.Mckern, M.Lou, T.C.Elleman, T.E.Adams, G.O.Lovrecz, H.-J.Zhu, F.Walker, M.J.Frenkel, P.A.Hoyne, R.N.Jorissen, E.C.Nice, A.W.Burgess, C.W.Ward. Crystal Structure of A Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor Alpha Cell(Cambridge,Mass.) V. 110 763 2002.
ISSN: ISSN 0092-8674
PubMed: 12297049
DOI: 10.1016/S0092-8674(02)00940-6
Page generated: Sat Jul 20 00:11:18 2024

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