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Chlorine in PDB 1mwt: Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution.

Enzymatic activity of Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution.

All present enzymatic activity of Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution.:
3.4.16.4;

Protein crystallography data

The structure of Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution., PDB code: 1mwt was solved by D.C.Lim, N.C.J.Strynadka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.89 / 2.45
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 80.545, 103.272, 186.825, 90.00, 90.00, 90.00
R / Rfree (%) 23.3 / 29.5

Other elements in 1mwt:

The structure of Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution. also contains other interesting chemical elements:

Cadmium (Cd) 9 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution. (pdb code 1mwt). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution., PDB code: 1mwt:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 1mwt

Go back to Chlorine Binding Sites List in 1mwt
Chlorine binding site 1 out of 4 in the Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1005

b:36.9
occ:1.00
 CD A:CD1001 2.5 35.4 1.0
OG1 A:THR300 3.2 45.9 1.0
O A:HOH1141 3.4 30.4 1.0
CG A:GLU145 3.6 39.8 1.0
OE2 B:GLU145 3.7 37.2 1.0
OE1 A:GLU145 3.8 41.5 1.0
CD1 A:ILE309 3.9 48.0 1.0
CG2 A:VAL302 4.0 42.8 1.0
CG1 A:ILE309 4.0 47.9 1.0
ND1 A:HIS143 4.0 41.0 1.0
CB A:HIS143 4.1 36.7 1.0
CD A:GLU145 4.2 45.3 1.0
CB A:THR300 4.3 38.0 1.0
CG A:HIS143 4.5 40.5 1.0
CG2 A:THR300 4.5 34.8 1.0
CD B:GLU145 4.6 38.0 1.0
OE1 B:GLU145 4.7 37.0 1.0
CB A:GLU145 4.9 38.4 1.0

Chlorine binding site 2 out of 4 in 1mwt

Go back to Chlorine Binding Sites List in 1mwt
Chlorine binding site 2 out of 4 in the Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1006

b:38.5
occ:1.00
 CD A:CD1002 2.5 42.6 1.0
NE2 A:GLN137 2.9 55.7 1.0
NE2 A:HIS311 3.5 38.6 1.0
O A:GLY135 3.6 38.0 1.0
CD A:GLN137 3.6 55.6 1.0
CG B:GLN207 3.8 57.0 1.0
CB A:ALA310 3.9 43.9 1.0
CD2 A:HIS311 3.9 34.3 1.0
NE2 A:GLN140 3.9 41.9 1.0
OD1 B:ASP209 4.2 44.6 1.0
CG A:GLN137 4.2 51.3 1.0
OE1 A:GLN137 4.2 51.3 1.0
CB B:GLN207 4.3 56.0 1.0
OE1 A:GLN140 4.4 38.7 1.0
CE1 A:HIS311 4.5 34.5 1.0
CD A:GLN140 4.6 39.7 1.0
OG1 B:THR210 4.6 49.6 1.0
C A:GLY135 4.8 37.8 1.0
CD B:GLN207 4.8 58.5 1.0
CB A:GLN137 4.9 43.4 1.0

Chlorine binding site 3 out of 4 in 1mwt

Go back to Chlorine Binding Sites List in 1mwt
Chlorine binding site 3 out of 4 in the Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl706

b:30.6
occ:1.00
 CD B:CD701 2.4 34.3 1.0
O A:HOH1147 3.1 18.5 1.0
OG1 B:THR300 3.2 31.9 1.0
CG B:GLU145 3.5 40.2 1.0
NH2 B:ARG298 3.5 60.5 1.0
OE2 A:GLU145 3.6 43.9 1.0
OE1 B:GLU145 3.6 37.0 1.0
ND1 B:HIS143 3.6 37.9 1.0
CB B:HIS143 3.9 26.9 1.0
CG2 B:VAL302 3.9 42.0 1.0
CD B:GLU145 4.0 38.0 1.0
CD1 B:ILE309 4.1 25.5 1.0
CG1 B:ILE309 4.1 33.5 1.0
CG B:HIS143 4.2 33.6 1.0
CB B:THR300 4.3 30.4 1.0
CZ B:ARG298 4.3 59.7 1.0
NE B:ARG298 4.3 55.2 1.0
CD A:GLU145 4.5 45.3 1.0
CG2 B:THR300 4.5 25.7 1.0
OE1 A:GLU145 4.5 41.5 1.0
CE1 B:HIS143 4.7 37.2 1.0
CB B:GLU145 4.8 36.8 1.0

Chlorine binding site 4 out of 4 in 1mwt

Go back to Chlorine Binding Sites List in 1mwt
Chlorine binding site 4 out of 4 in the Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of Penicillin G Acyl-Penicillin Binding Protein 2A From Methicillin Resistant Staphylococcus Aureus Strain 27R at 2.45 A Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl707

b:32.2
occ:1.00
 CD B:CD702 2.5 35.8 1.0
O B:GLY135 3.6 26.1 1.0
CD B:GLN137 3.6 47.2 1.0
NE2 B:HIS311 3.6 31.1 1.0
NE2 B:GLN140 3.7 35.5 1.0
OE1 B:GLN137 3.7 49.0 1.0
CB B:ALA310 3.8 36.5 1.0
CG B:GLN137 3.9 43.2 1.0
CD2 B:HIS311 3.9 30.6 1.0
NE2 B:GLN137 4.0 49.7 1.0
CG A:GLN207 4.0 46.1 1.0
OD2 A:ASP209 4.1 37.6 1.0
CB A:GLN207 4.2 43.9 1.0
OE1 B:GLN140 4.3 35.7 1.0
CD B:GLN140 4.4 36.4 1.0
CE1 B:HIS311 4.7 29.0 1.0
C B:GLY135 4.8 31.8 1.0
OG1 A:THR210 4.8 38.6 1.0
CA B:ALA310 4.9 37.6 1.0
O B:ALA310 5.0 37.1 1.0

Reference:

D.Lim, N.C.Strynadka. Structural Basis For the Beta Lactam Resistance of PBP2A From Methicillin-Resistant Staphylococcus Aureus. Nat.Struct.Biol. V. 9 870 2002.
ISSN: ISSN 1072-8368
PubMed: 12389036
Page generated: Sat Jul 20 00:13:56 2024

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