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Chlorine in PDB 1n4s: Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product

Enzymatic activity of Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product

All present enzymatic activity of Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product:
2.5.1.58; 2.5.1.59;

Protein crystallography data

The structure of Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product, PDB code: 1n4s was solved by J.S.Taylor, T.S.Reid, P.J.Casey, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.98 / 2.60
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 271.121, 268.426, 184.818, 90.00, 131.58, 90.00
R / Rfree (%) 19.4 / 21.4

Other elements in 1n4s:

The structure of Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product also contains other interesting chemical elements:

Zinc (Zn) 6 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product (pdb code 1n4s). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 9 binding sites of Chlorine where determined in the Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product, PDB code: 1n4s:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;

Chlorine binding site 1 out of 9 in 1n4s

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Chlorine binding site 1 out of 9 in the Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1401

b:61.9
occ:1.00
 N B:PHE286 3.3 49.2 1.0
N B:GLN287 3.4 50.6 1.0
C B:LYS284 3.5 49.5 1.0
N B:ILE285 3.7 49.0 1.0
CA B:LYS284 3.8 49.8 1.0
O B:LYS284 3.8 50.1 1.0
CB B:PHE286 3.8 48.5 1.0
CB B:GLN287 3.9 50.9 1.0
CG B:GLN287 3.9 52.2 1.0
CA B:PHE286 3.9 49.7 1.0
NE2 B:GLN287 4.0 51.2 1.0
C B:ILE285 4.1 48.6 1.0
C B:PHE286 4.1 50.5 1.0
CA B:ILE285 4.2 48.4 1.0
CD B:LYS281 4.2 54.2 1.0
CA B:GLN287 4.2 51.5 1.0
CD B:GLN287 4.3 52.7 1.0
O B:LYS281 4.3 53.1 1.0
CA B:LYS281 4.4 49.8 1.0
O B:LEU280 4.6 47.4 1.0
NZ B:LYS281 4.6 59.4 1.0
CE B:LYS281 4.7 56.6 1.0
N B:LYS284 4.7 50.0 1.0
CB B:LYS284 4.8 52.2 1.0
C B:LYS281 4.8 50.4 1.0

Chlorine binding site 2 out of 9 in 1n4s

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Chlorine binding site 2 out of 9 in the Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1402

b:59.5
occ:1.00
 NH2 C:ARG287 3.1 74.2 1.0
NH2 C:ARG291 3.3 57.0 1.0
OH C:TYR292 3.5 58.6 1.0
NE C:ARG253 3.8 68.7 1.0
NH1 C:ARG291 4.0 58.5 1.0
CZ C:ARG287 4.1 73.7 1.0
NH2 C:ARG253 4.1 70.9 1.0
NE C:ARG287 4.1 72.2 1.0
CZ C:ARG291 4.2 56.4 1.0
CZ C:ARG253 4.4 71.2 1.0
CG2 I:VAL64 4.4 53.8 1.0
CZ C:TYR292 4.5 56.9 1.0
CG C:ARG253 4.6 64.4 1.0
CE1 C:TYR292 4.7 57.3 1.0
CD C:ARG253 4.7 67.1 1.0
CD2 C:LEU256 4.8 54.6 1.0

Chlorine binding site 3 out of 9 in 1n4s

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Chlorine binding site 3 out of 9 in the Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1403

b:43.9
occ:1.00
 N D:GLN287 3.1 36.6 1.0
N D:PHE286 3.1 35.1 1.0
C D:LYS284 3.5 38.8 1.0
N D:ILE285 3.6 35.3 1.0
CG D:GLN287 3.6 43.0 1.0
CB D:PHE286 3.7 30.6 1.0
CB D:GLN287 3.7 37.5 1.0
CA D:PHE286 3.7 34.7 1.0
O D:HOH1529 3.8 50.9 1.0
O D:LYS284 3.8 38.2 1.0
CA D:LYS284 3.9 41.1 1.0
C D:PHE286 3.9 36.1 1.0
C D:ILE285 3.9 35.1 1.0
CA D:GLN287 4.0 38.3 1.0
NE2 D:GLN287 4.1 45.7 1.0
CA D:ILE285 4.1 34.0 1.0
CD D:GLN287 4.2 45.5 1.0
CD D:LYS281 4.3 46.0 1.0
CA D:LYS281 4.4 39.0 1.0
O D:LYS281 4.5 38.1 1.0
O D:LEU280 4.6 38.2 1.0
N D:LYS284 4.8 42.3 1.0
O D:ILE285 4.9 34.0 1.0
CG D:PHE286 4.9 29.1 1.0
CB D:LYS284 4.9 42.7 1.0
NZ D:LYS281 4.9 53.1 1.0
C D:LYS281 5.0 38.1 1.0

Chlorine binding site 4 out of 9 in 1n4s

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Chlorine binding site 4 out of 9 in the Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl1404

b:47.2
occ:1.00
 N F:PHE286 3.4 39.8 1.0
N F:GLN287 3.4 40.7 1.0
C F:LYS284 3.6 38.9 1.0
N F:ILE285 3.7 38.3 1.0
CA F:LYS284 3.8 39.2 1.0
CG F:GLN287 3.8 42.9 1.0
CB F:PHE286 3.9 40.0 1.0
CB F:GLN287 3.9 40.8 1.0
O F:LYS284 3.9 38.8 1.0
NE2 F:GLN287 4.0 41.6 1.0
CA F:PHE286 4.0 39.5 1.0
CD F:LYS281 4.0 47.2 1.0
C F:ILE285 4.1 39.1 1.0
C F:PHE286 4.2 39.8 1.0
CA F:GLN287 4.2 40.6 1.0
CA F:ILE285 4.2 38.0 1.0
CD F:GLN287 4.3 44.1 1.0
O F:LYS281 4.4 42.4 1.0
CA F:LYS281 4.4 40.0 1.0
O F:LEU280 4.6 39.6 1.0
N F:LYS284 4.7 40.5 1.0
CB F:LYS284 4.8 38.9 1.0
CE F:LYS281 4.8 49.7 1.0
CG F:LYS281 4.9 43.5 1.0
C F:LYS281 4.9 39.9 1.0

Chlorine binding site 5 out of 9 in 1n4s

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Chlorine binding site 5 out of 9 in the Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Cl1405

b:53.8
occ:1.00
 O G:HOH1411 2.3 45.6 1.0
NH2 G:ARG287 3.4 69.5 1.0
OH G:TYR292 3.4 51.4 1.0
NE G:ARG253 3.7 57.5 1.0
NH2 G:ARG291 3.9 45.1 1.0
NE G:ARG287 4.1 64.8 1.0
CG G:ARG253 4.1 52.8 1.0
CZ G:ARG287 4.2 67.7 1.0
NH1 G:ARG291 4.3 44.5 1.0
CD2 G:LEU256 4.3 43.9 1.0
CD G:ARG253 4.5 55.8 1.0
CZ G:TYR292 4.5 51.9 1.0
NH2 G:ARG253 4.5 58.4 1.0
CZ G:ARG291 4.6 45.8 1.0
CZ G:ARG253 4.6 58.6 1.0
CE1 G:TYR292 4.7 51.7 1.0
O G:HOH1436 4.7 46.4 1.0

Chlorine binding site 6 out of 9 in 1n4s

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Chlorine binding site 6 out of 9 in the Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Cl1406

b:60.6
occ:1.00
 N H:PHE286 3.2 50.1 1.0
N H:GLN287 3.3 52.5 1.0
C H:LYS284 3.4 49.9 1.0
N H:ILE285 3.6 48.0 1.0
CA H:LYS284 3.7 50.8 1.0
CB H:PHE286 3.7 51.9 1.0
O H:LYS284 3.7 50.1 1.0
CA H:PHE286 3.8 51.8 1.0
CB H:GLN287 3.9 54.1 1.0
C H:ILE285 4.0 48.9 1.0
CG H:GLN287 4.0 56.8 1.0
NE2 H:GLN287 4.0 56.2 1.0
C H:PHE286 4.1 51.9 1.0
CA H:ILE285 4.1 48.3 1.0
CA H:GLN287 4.2 53.2 1.0
CA H:LYS281 4.3 52.0 1.0
CD H:LYS281 4.3 60.2 1.0
CD H:GLN287 4.3 57.0 1.0
O H:LYS281 4.3 52.9 1.0
O H:LEU280 4.5 51.4 1.0
N H:LYS284 4.7 52.4 1.0
CB H:LYS284 4.8 50.4 1.0
C H:LYS281 4.8 52.1 1.0
CE H:LYS281 4.9 65.1 1.0
O H:ILE285 5.0 47.7 1.0
NZ H:LYS281 5.0 65.6 1.0
CG H:PHE286 5.0 52.6 1.0

Chlorine binding site 7 out of 9 in 1n4s

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Chlorine binding site 7 out of 9 in the Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Cl1407

b:61.5
occ:1.00
 N J:PHE286 3.2 48.0 1.0
N J:GLN287 3.3 52.3 1.0
C J:LYS284 3.5 48.7 1.0
N J:ILE285 3.6 46.5 1.0
CB J:PHE286 3.7 49.4 1.0
CA J:PHE286 3.8 50.2 1.0
CA J:LYS284 3.8 49.6 1.0
O J:LYS284 3.9 49.2 1.0
NZ J:LYS281 3.9 62.9 1.0
CB J:GLN287 3.9 53.8 1.0
CG J:GLN287 3.9 58.8 1.0
C J:ILE285 4.0 46.9 1.0
C J:PHE286 4.0 50.9 1.0
NE2 J:GLN287 4.0 58.1 1.0
CD J:LYS281 4.0 57.5 1.0
CA J:ILE285 4.1 46.2 1.0
CA J:GLN287 4.2 52.3 1.0
CA J:LYS281 4.3 48.7 1.0
CE J:LYS281 4.3 59.8 1.0
O J:LYS281 4.3 50.1 1.0
CD J:GLN287 4.3 59.4 1.0
O J:LEU280 4.5 49.0 1.0
N J:LYS284 4.7 50.5 1.0
C J:LYS281 4.8 48.4 1.0
CB J:LYS284 4.8 51.1 1.0
CG J:PHE286 4.9 49.9 1.0
O J:ILE285 5.0 47.1 1.0

Chlorine binding site 8 out of 9 in 1n4s

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Chlorine binding site 8 out of 9 in the Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Cl1408

b:57.4
occ:1.00
 O K:HOH1417 2.4 47.8 1.0
O K:HOH1477 2.8 57.0 1.0
O A:HOH408 3.1 43.3 1.0
OH K:TYR292 3.2 51.4 1.0
NH2 K:ARG287 3.3 65.1 1.0
NE K:ARG253 3.9 55.4 1.0
NH2 K:ARG291 4.1 46.0 1.0
NE K:ARG287 4.1 61.6 1.0
CZ K:ARG287 4.2 64.7 1.0
NH1 K:ARG291 4.2 44.1 1.0
CZ K:TYR292 4.2 48.3 1.0
CE1 K:TYR292 4.3 48.0 1.0
CD2 K:LEU256 4.3 34.5 1.0
CG2 A:VAL64 4.4 40.3 1.0
CG K:ARG253 4.4 47.4 1.0
CD K:ARG253 4.6 52.5 1.0
CZ K:ARG291 4.6 45.5 1.0
NH2 K:ARG253 4.7 55.5 1.0
CZ K:ARG253 4.7 56.9 1.0

Chlorine binding site 9 out of 9 in 1n4s

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Chlorine binding site 9 out of 9 in the Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Protein Geranylgeranyltransferase Type-I Complexed with Ggpp and A Geranylgeranylated Kkksktkcvil Peptide Product within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Cl1409

b:45.3
occ:1.00
 O L:HOH1608 3.2 49.2 1.0
N L:PHE286 3.2 31.8 1.0
N L:GLN287 3.3 34.8 1.0
C L:LYS284 3.4 37.1 1.0
N L:ILE285 3.5 34.0 1.0
CA L:LYS284 3.7 38.4 1.0
O L:LYS284 3.7 38.7 1.0
CB L:PHE286 3.8 30.5 1.0
CG L:GLN287 3.8 41.3 1.0
CA L:PHE286 3.8 33.3 1.0
NE2 L:GLN287 3.9 40.4 1.0
CB L:GLN287 3.9 35.6 1.0
C L:ILE285 3.9 32.5 1.0
CA L:ILE285 4.0 32.8 1.0
C L:PHE286 4.1 33.8 1.0
CA L:GLN287 4.2 36.1 1.0
CD L:GLN287 4.2 40.8 1.0
CD L:LYS281 4.2 45.1 1.0
CA L:LYS281 4.3 35.2 1.0
O L:LYS281 4.3 36.8 1.0
O L:LEU280 4.6 34.2 1.0
N L:LYS284 4.6 38.6 1.0
CB L:LYS284 4.7 41.5 1.0
CE L:LYS281 4.8 51.7 1.0
C L:LYS281 4.8 35.7 1.0
NZ L:LYS281 4.8 52.1 1.0
O L:ILE285 4.9 32.7 1.0

Reference:

J.S.Taylor, T.S.Reid, K.L.Terry, P.J.Casey, L.S.Beese. Structure of Mammalian Protein Geranylgeranyltransferase Type-I Embo J. V. 22 5963 2003.
ISSN: ISSN 0261-4189
PubMed: 14609943
DOI: 10.1093/EMBOJ/CDG571
Page generated: Sat Jul 20 00:18:20 2024

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