Chlorine in PDB 1nzv: Crystal Structure of Src SH2 Domain Bound to Doubly Phosphorylated Peptide Pqpyipyvpa

All present enzymatic activity of Crystal Structure of Src SH2 Domain Bound to Doubly Phosphorylated Peptide Pqpyipyvpa:
2.7.1.112;

The structure of Crystal Structure of Src SH2 Domain Bound to Doubly Phosphorylated Peptide Pqpyipyvpa, PDB code: 1nzv was solved by O.Y.Lubman, G.Waksman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.64 / 2.10
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	100.256, 67.727, 29.636, 90.00, 90.00, 90.00
R / Rfree (%)	22.4 / 27.1

The binding sites of Chlorine atom in the Crystal Structure of Src SH2 Domain Bound to Doubly Phosphorylated Peptide Pqpyipyvpa (pdb code 1nzv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Src SH2 Domain Bound to Doubly Phosphorylated Peptide Pqpyipyvpa, PDB code: 1nzv:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Src SH2 Domain Bound to Doubly Phosphorylated Peptide Pqpyipyvpa


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Src SH2 Domain Bound to Doubly Phosphorylated Peptide Pqpyipyvpa within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2000 b:31.4 occ:1.00 OG A:SER179 3.5 27.4 1.0 OG1 A:THR181 3.6 33.2 1.0 N A:GLU180 3.6 29.2 1.0 CL A:CL2001 3.7 61.0 1.0 SG A:CYS187 3.9 29.0 1.0 CB A:GLU180 3.9 30.7 1.0 N A:THR181 3.9 30.9 1.0 O A:HOH1092 4.0 23.9 1.0 NH2 A:ARG177 4.2 14.3 1.0 NH1 A:ARG177 4.2 15.3 1.0 CA A:SER179 4.3 26.0 1.0 CA A:GLU180 4.3 30.2 1.0 CG2 A:THR181 4.4 32.6 1.0 CB A:SER179 4.4 27.1 1.0 CB A:THR181 4.4 33.2 1.0 C A:SER179 4.4 27.5 1.0 C A:GLU180 4.6 30.8 1.0 CZ A:ARG177 4.7 15.1 1.0 CA A:THR181 4.8 32.4 1.0 OE1 A:GLU180 4.8 34.1 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Src SH2 Domain Bound to Doubly Phosphorylated Peptide Pqpyipyvpa


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Src SH2 Domain Bound to Doubly Phosphorylated Peptide Pqpyipyvpa within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2001 b:61.0 occ:1.00 O A:HOH1092 2.6 23.9 1.0 CL A:CL2000 3.7 31.4 1.0 CD A:LYS205 4.3 25.8 1.0 CB A:LYS205 4.3 20.5 1.0 OG1 A:THR181 4.4 33.2 1.0 CG A:LYS205 4.5 23.5 1.0 SG A:CYS187 5.0 29.0 1.0

O.Y.Lubman, G.Waksman. Structural and Thermodynamic Basis For the Interaction of the Src SH2 Domain with the Activated Form of the Pdgf Beta-Receptor J.Mol.Biol. V. 328 655 2003.
ISSN: ISSN 0022-2836
PubMed: 12706723
DOI: 10.1016/S0022-2836(03)00344-9