Chlorine in PDB 1o5m: Structure of Fpt Bound to the Inhibitor SCH66336

The structure of Structure of Fpt Bound to the Inhibitor SCH66336, PDB code: 1o5m was solved by C.L.Strickland, P.C.Weber, A.K.Ganguly, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	8.00 / 2.30
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	171.110, 171.110, 69.310, 90.00, 90.00, 120.00
R / Rfree (%)	17.4 / n/a

The structure of Structure of Fpt Bound to the Inhibitor SCH66336 also contains other interesting chemical elements:

Bromine	(Br)	2 atoms
Zinc	(Zn)	1 atom

The binding sites of Chlorine atom in the Structure of Fpt Bound to the Inhibitor SCH66336 (pdb code 1o5m). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Fpt Bound to the Inhibitor SCH66336, PDB code: 1o5m:

Chlorine binding site 1 out of 1 in the Structure of Fpt Bound to the Inhibitor SCH66336


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Fpt Bound to the Inhibitor SCH66336 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl3001 b:28.0 occ:1.00 CL16 B:3363001 0.0 28.0 1.0 C19 B:3363001 1.7 20.4 1.0 C35 B:3363001 2.7 21.7 1.0 C20 B:3363001 2.7 18.9 1.0 CH2 B:TRP102 3.5 21.8 1.0 CZ3 B:TRP102 3.6 19.5 1.0 CZ2 B:TRP303 3.7 11.4 1.0 C15 B:FPP2001 3.9 16.2 1.0 OH B:TYR365 3.9 18.4 1.0 CE1 B:TYR361 3.9 9.3 1.0 CZ2 B:TRP102 4.0 23.3 1.0 C13 B:FPP2001 4.0 15.1 1.0 C28 B:3363001 4.0 21.8 1.0 C11 B:FPP2001 4.0 14.7 1.0 C42 B:3363001 4.0 20.9 1.0 C12 B:FPP2001 4.0 11.0 1.0 CH2 B:TRP303 4.2 12.3 1.0 CE3 B:TRP102 4.2 21.8 1.0 NE1 B:TRP106 4.3 16.0 1.0 CE1 B:TYR365 4.3 16.7 1.0 CD1 B:TYR361 4.4 9.6 1.0 CZ B:TYR365 4.4 16.3 1.0 CE2 B:TRP102 4.4 20.2 1.0 C40 B:3363001 4.5 19.9 1.0 CD2 B:TRP102 4.6 20.6 1.0 CZ2 B:TRP106 4.6 22.7 1.0 C14 B:FPP2001 4.8 14.6 1.0 CE2 B:TRP106 4.8 20.8 1.0 CE2 B:TRP303 4.9 10.3 1.0 CZ B:TYR361 5.0 10.2 1.0

C.L.Strickland, P.C.Weber, W.T.Windsor, Z.Wu, H.V.Le, M.M.Albanese, C.S.Alvarez, D.Cesarz, J.Del Rosario, J.Deskus, A.K.Mallams, F.G.Njoroge, J.J.Piwinski, S.Remiszewski, R.R.Rossman, A.G.Taveras, B.Vibulbhan, R.J.Doll, V.M.Girijavallabhan, A.K.Ganguly. Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure-Activity Relationships J.Med.Chem. V. 42 2125 1999.
ISSN: ISSN 0022-2623
PubMed: 10377218
DOI: 10.1021/JM990030G