Chlorine in PDB 1o8a: Crystal Structure of Human Angiotensin Converting Enzyme (Native).

All present enzymatic activity of Crystal Structure of Human Angiotensin Converting Enzyme (Native).:
3.4.15.1;

The structure of Crystal Structure of Human Angiotensin Converting Enzyme (Native)., PDB code: 1o8a was solved by R.Natesh, S.L.U.Schwager, E.D.Sturrock, K.R.Acharya, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.14 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	56.620, 85.060, 133.790, 90.00, 90.00, 90.00
R / Rfree (%)	18 / 22

The structure of Crystal Structure of Human Angiotensin Converting Enzyme (Native). also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Chlorine atom in the Crystal Structure of Human Angiotensin Converting Enzyme (Native). (pdb code 1o8a). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Angiotensin Converting Enzyme (Native)., PDB code: 1o8a:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Human Angiotensin Converting Enzyme (Native).


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Angiotensin Converting Enzyme (Native). within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl703 b:16.5 occ:1.00 NH1 A:ARG489 3.2 11.5 1.0 NE A:ARG186 3.2 15.2 1.0 O A:HOH2422 3.2 13.9 1.0 NE1 A:TRP485 3.3 15.0 1.0 NH1 A:ARG186 3.3 16.8 1.0 CZ2 A:TRP486 3.5 11.4 1.0 CZ A:ARG186 3.7 15.6 1.0 NE A:ARG489 3.7 11.4 1.0 CZ A:ARG489 3.7 14.2 1.0 CB A:ASP507 3.8 14.4 1.0 CH2 A:TRP486 4.0 11.2 1.0 CE2 A:TRP485 4.2 14.6 1.0 CE2 A:TRP486 4.3 11.1 1.0 CD1 A:TRP485 4.3 15.3 1.0 CZ2 A:TRP485 4.3 14.8 1.0 CD A:ARG186 4.3 15.8 1.0 CZ2 A:TRP182 4.5 14.2 1.0 O A:ASP507 4.6 14.2 1.0 CG A:ASP507 4.6 14.0 1.0 NE1 A:TRP486 4.7 12.7 1.0 O A:HOH2271 4.7 12.7 1.0 C A:ASP507 4.8 13.6 1.0 CA A:ASP507 4.8 12.9 1.0 NH2 A:ARG489 4.9 8.8 1.0 CD A:ARG489 4.9 11.2 1.0 OD2 A:ASP507 4.9 16.2 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Human Angiotensin Converting Enzyme (Native).


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Angiotensin Converting Enzyme (Native). within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl704 b:16.6 occ:1.00 O A:HOH2195 3.0 15.5 1.0 OH A:TYR224 3.0 13.1 1.0 NE A:ARG522 3.1 10.9 1.0 CB A:ARG522 3.5 11.3 1.0 NH2 A:ARG522 3.6 13.8 1.0 CG2 A:ILE521 3.6 10.8 1.0 CB A:PRO407 3.6 14.6 1.0 CB A:PRO519 3.6 12.9 1.0 N A:ARG522 3.6 11.2 1.0 CE1 A:TYR224 3.6 13.7 1.0 CE A:MET223 3.7 27.1 1.0 CZ A:TYR224 3.8 13.4 1.0 CZ A:ARG522 3.8 13.8 1.0 CG A:PRO407 3.9 16.2 1.0 CG A:ARG522 3.9 13.0 1.0 CA A:ARG522 4.0 10.9 1.0 CD A:ARG522 4.1 13.7 1.0 C A:ILE521 4.6 11.7 1.0 N A:ILE521 4.6 10.6 1.0 C A:PRO519 4.6 13.4 1.0 CG A:PRO519 4.6 13.9 1.0 SD A:MET223 4.7 31.0 1.0 CA A:PRO519 4.7 13.7 1.0 O A:PRO519 4.8 12.7 1.0 O A:HOH2381 4.8 12.9 1.0 CB A:ILE521 4.8 10.5 1.0 CD A:PRO407 4.8 14.9 1.0 CA A:ILE521 4.9 10.7 1.0 CD1 A:TYR224 4.9 12.7 1.0 N A:TYR520 4.9 12.5 1.0

R.Natesh, S.L.Schwager, E.D.Sturrock, K.R.Acharya. Crystal Structure of the Human Angiotensin-Converting Enzyme-Lisinopril Complex. Nature V. 421 551 2003.
ISSN: ISSN 0028-0836
PubMed: 12540854
DOI: 10.1038/NATURE01370