Chlorine in PDB 1oec: FGFR2 Kinase Domain

All present enzymatic activity of FGFR2 Kinase Domain:
2.7.1.112;

The structure of FGFR2 Kinase Domain, PDB code: 1oec was solved by T.A.Ceska, R.Owens, C.Doyle, P.Hamlyn, T.Crabbe, D.Moffat, J.Davis, R.Martin, M.J.Perry, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	100 / 2.4
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	69.760, 80.500, 120.170, 90.00, 90.00, 90.00
R / Rfree (%)	21.1 / 28.5

The binding sites of Chlorine atom in the FGFR2 Kinase Domain (pdb code 1oec). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the FGFR2 Kinase Domain, PDB code: 1oec:

Chlorine binding site 1 out of 1 in the FGFR2 Kinase Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of FGFR2 Kinase Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl789 b:7.4 occ:1.00 CL20 A:AA2789 0.0 7.4 1.0 C5 A:AA2789 1.8 22.4 1.0 C6 A:AA2789 2.7 24.2 1.0 C4 A:AA2789 2.8 31.5 1.0 C12 A:AA2789 3.0 35.5 1.0 C7 A:AA2789 3.2 32.8 1.0 CG2 A:VAL564 3.7 26.5 1.0 CD1 A:LEU633 3.9 36.1 1.0 N1 A:AA2789 4.0 27.2 1.0 N3 A:AA2789 4.1 30.0 1.0 C11 A:AA2789 4.2 37.2 1.0 CD1 A:ILE548 4.3 50.6 1.0 CG1 A:VAL495 4.3 37.1 1.0 CB A:ALA515 4.4 31.3 1.0 C8 A:AA2789 4.5 31.8 1.0 C2 A:AA2789 4.5 30.0 1.0 CD A:LYS517 4.6 39.2 1.0 O A:GLU565 4.7 38.5 1.0 CG A:LYS517 4.7 37.9 1.0 NZ A:LYS517 4.7 48.6 1.0 CG2 A:VAL495 4.8 43.1 1.0 CE A:LYS517 4.9 44.5 1.0 O A:HOH2036 4.9 37.5 1.0 CB A:VAL564 5.0 32.5 1.0

T.A.Ceska, R.Owens, C.Doyle, P.Hamlyn, T.Crabbe, D.Moffat, J.Davis, R.Martin, M.J.Perry. The Crystal Structure of the FGFR2 Tyrosine Kinase Domain in Complex with 4-Aryl-2-Phenylamino Pyrimidine Angiogenesis Inhibitors To Be Published.