Chlorine in PDB 1qhs: Chloramphenicol Phosphotransferase in Complex with Chloramphenicol From Streptomyces Venezuelae

The structure of Chloramphenicol Phosphotransferase in Complex with Chloramphenicol From Streptomyces Venezuelae, PDB code: 1qhs was solved by T.Izard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	99.00 / 2.80
Space group	I 41 3 2
Cell size a, b, c (Å), α, β, γ (°)	200.000, 200.000, 200.000, 90.00, 90.00, 90.00
R / Rfree (%)	22.6 / 23.8

The binding sites of Chlorine atom in the Chloramphenicol Phosphotransferase in Complex with Chloramphenicol From Streptomyces Venezuelae (pdb code 1qhs). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Chloramphenicol Phosphotransferase in Complex with Chloramphenicol From Streptomyces Venezuelae, PDB code: 1qhs:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Chloramphenicol Phosphotransferase in Complex with Chloramphenicol From Streptomyces Venezuelae


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Chloramphenicol Phosphotransferase in Complex with Chloramphenicol From Streptomyces Venezuelae within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl999 b:31.6 occ:1.00 CL1 A:CLM999 0.0 31.6 1.0 C1 A:CLM999 1.7 31.6 1.0 C2 A:CLM999 2.7 31.6 1.0 CL2 A:CLM999 2.8 31.6 1.0 O2 A:CLM999 3.2 31.6 1.0 CZ A:PHE56 3.4 41.9 1.0 N2 A:CLM999 3.6 31.6 1.0 O A:HOH1029 3.8 27.2 1.0 O A:HOH1010 3.9 38.0 1.0 CD1 A:ILE40 3.9 23.6 1.0 O A:HOH1015 4.0 23.6 1.0 CE2 A:PHE56 4.0 41.9 1.0 CE1 A:PHE56 4.0 41.9 1.0 CG2 A:ILE40 4.2 23.6 1.0 O A:HOH1006 4.4 29.8 1.0 OD1 A:ASP37 4.7 33.2 1.0 C7 A:CLM999 4.8 31.6 1.0 CB A:ILE40 4.9 23.6 1.0 C3 A:CLM999 4.9 31.6 1.0 CG1 A:ILE40 5.0 23.6 1.0

Chlorine binding site 2 out of 4 in the Chloramphenicol Phosphotransferase in Complex with Chloramphenicol From Streptomyces Venezuelae


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Chloramphenicol Phosphotransferase in Complex with Chloramphenicol From Streptomyces Venezuelae within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl999 b:31.6 occ:1.00 CL2 A:CLM999 0.0 31.6 1.0 C1 A:CLM999 1.8 31.6 1.0 C2 A:CLM999 2.7 31.6 1.0 CL1 A:CLM999 2.8 31.6 1.0 O2 A:CLM999 2.9 31.6 1.0 O A:HOH1015 3.5 23.6 1.0 NH2 A:ARG136 3.6 35.3 1.0 CZ A:ARG136 3.7 35.3 1.0 N2 A:CLM999 3.8 31.6 1.0 O A:HOH1029 3.8 27.2 1.0 O A:HOH1044 4.0 28.7 1.0 NH1 A:ARG136 4.0 35.3 1.0 O A:HOH1006 4.0 29.8 1.0 NE A:ARG136 4.1 35.3 1.0 OD1 A:ASP37 4.4 33.2 1.0 CG A:ASP37 4.6 33.2 1.0 OD2 A:ASP37 4.8 33.2 1.0 O A:HOH1010 4.8 38.0 1.0 CD A:ARG136 4.9 35.3 1.0

Chlorine binding site 3 out of 4 in the Chloramphenicol Phosphotransferase in Complex with Chloramphenicol From Streptomyces Venezuelae


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Chloramphenicol Phosphotransferase in Complex with Chloramphenicol From Streptomyces Venezuelae within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl888 b:28.8 occ:0.50 CL1 A:CLM888 0.0 28.8 0.5 C1 A:CLM888 1.7 28.8 0.5 C2 A:CLM888 2.7 28.8 0.5 CL2 A:CLM888 2.8 28.8 0.5 O2 A:CLM888 3.2 28.8 0.5 CB A:LYS46 3.4 34.6 1.0 N2 A:CLM888 3.5 28.8 0.5 O A:LYS46 3.5 40.4 1.0 CB A:ALA50 3.6 33.8 1.0 CD A:LYS46 3.8 34.6 1.0 CG A:LYS46 4.0 34.6 1.0 C A:LYS46 4.1 40.4 1.0 C7 A:CLM888 4.1 28.8 0.5 C8 A:CLM888 4.1 28.8 0.5 CA A:LYS46 4.3 40.4 1.0 CA A:ALA50 4.3 54.2 1.0 N A:ALA50 4.4 54.2 1.0 O1 A:SO4602 4.5 44.3 0.5 O4 A:SO4602 4.6 44.3 0.5 C9 A:CLM888 4.6 28.8 0.5 C6 A:CLM888 4.6 28.8 0.5 C A:SER49 4.7 55.7 1.0 C3 A:CLM888 4.9 28.8 0.5 O A:SER49 4.9 55.7 1.0 N A:MET47 5.0 40.2 1.0

Chlorine binding site 4 out of 4 in the Chloramphenicol Phosphotransferase in Complex with Chloramphenicol From Streptomyces Venezuelae


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Chloramphenicol Phosphotransferase in Complex with Chloramphenicol From Streptomyces Venezuelae within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl888 b:28.8 occ:0.50 CL2 A:CLM888 0.0 28.8 0.5 C1 A:CLM888 1.8 28.8 0.5 C2 A:CLM888 2.7 28.8 0.5 CL1 A:CLM888 2.8 28.8 0.5 O2 A:CLM888 3.1 28.8 0.5 N2 A:CLM888 3.7 28.8 0.5 O1 A:SO4602 4.4 44.3 0.5

T.Izard, J.Ellis. The Crystal Structures of Chloramphenicol Phosphotransferase Reveal A Novel Inactivation Mechanism Embo J. V. 19 2690 2000.
ISSN: ISSN 0261-4189
PubMed: 10835366
DOI: 10.1093/EMBOJ/19.1.1