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Chlorine in PDB 1qpe: Structural Analysis of the Lymphocyte-Specific Kinase Lck in Complex with Non-Selective and Src Family Selective Kinase Inhibitors

Enzymatic activity of Structural Analysis of the Lymphocyte-Specific Kinase Lck in Complex with Non-Selective and Src Family Selective Kinase Inhibitors

All present enzymatic activity of Structural Analysis of the Lymphocyte-Specific Kinase Lck in Complex with Non-Selective and Src Family Selective Kinase Inhibitors:
2.7.1.112;

Protein crystallography data

The structure of Structural Analysis of the Lymphocyte-Specific Kinase Lck in Complex with Non-Selective and Src Family Selective Kinase Inhibitors, PDB code: 1qpe was solved by X.Zhu, K.A.Morgenstern, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 5.00 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 42.500, 74.090, 91.980, 90.00, 90.00, 90.00
R / Rfree (%) 18.9 / 25.4

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structural Analysis of the Lymphocyte-Specific Kinase Lck in Complex with Non-Selective and Src Family Selective Kinase Inhibitors (pdb code 1qpe). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structural Analysis of the Lymphocyte-Specific Kinase Lck in Complex with Non-Selective and Src Family Selective Kinase Inhibitors, PDB code: 1qpe:

Chlorine binding site 1 out of 1 in 1qpe

Go back to Chlorine Binding Sites List in 1qpe
Chlorine binding site 1 out of 1 in the Structural Analysis of the Lymphocyte-Specific Kinase Lck in Complex with Non-Selective and Src Family Selective Kinase Inhibitors


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structural Analysis of the Lymphocyte-Specific Kinase Lck in Complex with Non-Selective and Src Family Selective Kinase Inhibitors within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1904

b:23.2
occ:1.00
 CL A:PP21904 0.0 23.2 1.0
C14 A:PP21904 1.8 17.7 1.0
C15 A:PP21904 2.7 18.5 1.0
C13 A:PP21904 2.8 17.0 1.0
CG2 A:ILE314 3.5 7.6 0.8
OE2 A:GLU288 3.5 21.8 1.0
CD A:GLU288 3.7 19.1 1.0
CD A:LYS273 3.8 20.2 1.0
CG2 A:THR316 3.9 7.0 1.0
CB A:ILE314 4.0 8.3 0.8
O A:HOH2081 4.0 13.2 1.0
OE1 A:GLU288 4.0 20.4 1.0
C12 A:PP21904 4.1 18.9 1.0
C16 A:PP21904 4.1 19.1 1.0
CB A:LYS273 4.1 14.1 1.0
CD1 A:ILE314 4.2 9.1 0.8
SD A:MET292 4.4 15.1 1.0
CG A:GLU288 4.4 16.6 1.0
NZ A:LYS273 4.5 19.4 1.0
CG A:LYS273 4.6 18.3 1.0
C11 A:PP21904 4.6 19.2 1.0
CE A:LYS273 4.6 20.4 1.0
CG1 A:ILE314 4.7 9.2 0.8
O A:ILE314 4.9 4.8 0.8
CE A:MET292 5.0 8.9 1.0

Reference:

X.Zhu, J.L.Kim, J.R.Newcomb, P.E.Rose, D.R.Stover, L.M.Toledo, H.Zhao, K.A.Morgenstern. Structural Analysis of the Lymphocyte-Specific Kinase Lck in Complex with Non-Selective and Src Family Selective Kinase Inhibitors. Structure Fold.Des. V. 7 651 1999.
ISSN: ISSN 0969-2126
PubMed: 10404594
DOI: 10.1016/S0969-2126(99)80086-0
Page generated: Sat Dec 12 08:47:16 2020

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