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Chlorine in PDB 1qs4: Core Domain of Hiv-1 Integrase Complexed with Mg++ and 1-(5- Chloroindol-3-Yl)-3-Hydroxy-3-(2H-Tetrazol-5-Yl)-Propenone
Enzymatic activity of Core Domain of Hiv-1 Integrase Complexed with Mg++ and 1-(5- Chloroindol-3-Yl)-3-Hydroxy-3-(2H-Tetrazol-5-Yl)-Propenone
All present enzymatic activity of Core Domain of Hiv-1 Integrase Complexed with Mg++ and 1-(5- Chloroindol-3-Yl)-3-Hydroxy-3-(2H-Tetrazol-5-Yl)-Propenone:
2.7.7.49;
2.7.7.49;
Protein crystallography data
The structure of Core Domain of Hiv-1 Integrase Complexed with Mg++ and 1-(5- Chloroindol-3-Yl)-3-Hydroxy-3-(2H-Tetrazol-5-Yl)-Propenone, PDB code: 1qs4
was solved by
Y.Goldgur,
R.Craigie,
T.Fujiwara,
T.Yoshinaga,
D.R.Davies,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 38.07 / 2.10 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 76.233, 46.735, 141.361, 90.00, 105.55, 90.00 |
| R / Rfree (%) | 20.9 / 25.5 |
Other elements in 1qs4:
The structure of Core Domain of Hiv-1 Integrase Complexed with Mg++ and 1-(5- Chloroindol-3-Yl)-3-Hydroxy-3-(2H-Tetrazol-5-Yl)-Propenone also contains other interesting chemical elements:
| Magnesium | (Mg) | 3 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Core Domain of Hiv-1 Integrase Complexed with Mg++ and 1-(5- Chloroindol-3-Yl)-3-Hydroxy-3-(2H-Tetrazol-5-Yl)-Propenone
(pdb code 1qs4). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Core Domain of Hiv-1 Integrase Complexed with Mg++ and 1-(5- Chloroindol-3-Yl)-3-Hydroxy-3-(2H-Tetrazol-5-Yl)-Propenone, PDB code: 1qs4:
In total only one binding site of Chlorine was determined in the Core Domain of Hiv-1 Integrase Complexed with Mg++ and 1-(5- Chloroindol-3-Yl)-3-Hydroxy-3-(2H-Tetrazol-5-Yl)-Propenone, PDB code: 1qs4:
Chlorine binding site 1 out of 1 in 1qs4
Go back to
Chlorine Binding Sites List in 1qs4
Chlorine binding site 1 out
of 1 in the Core Domain of Hiv-1 Integrase Complexed with Mg++ and 1-(5- Chloroindol-3-Yl)-3-Hydroxy-3-(2H-Tetrazol-5-Yl)-Propenone
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Core Domain of Hiv-1 Integrase Complexed with Mg++ and 1-(5- Chloroindol-3-Yl)-3-Hydroxy-3-(2H-Tetrazol-5-Yl)-Propenone within 5.0Å range:
|
Reference:
Y.Goldgur,
R.Craigie,
G.H.Cohen,
T.Fujiwara,
T.Yoshinaga,
T.Fujishita,
H.Sugimoto,
T.Endo,
H.Murai,
D.R.Davies.
Structure of the Hiv-1 Integrase Catalytic Domain Complexed with An Inhibitor: A Platform For Antiviral Drug Design. Proc.Natl.Acad.Sci.Usa V. 96 13040 1999.
ISSN: ISSN 0027-8424
PubMed: 10557269
DOI: 10.1073/PNAS.96.23.13040
Page generated: Sat Dec 12 08:47:22 2020
ISSN: ISSN 0027-8424
PubMed: 10557269
DOI: 10.1073/PNAS.96.23.13040
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