Chlorine in PDB 1rwe: Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues

The structure of Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues, PDB code: 1rwe was solved by Z.Wan, B.Xu, Y.C.Chu, B.Li, S.H.Nakagawa, Y.Qu, S.Q.Hu, P.G.Katsoyannis, M.A.Weiss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.18 / 1.80
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	79.341, 79.341, 34.708, 90.00, 90.00, 120.00
R / Rfree (%)	18.9 / 24.5

The structure of Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues (pdb code 1rwe). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues, PDB code: 1rwe:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl202 b:43.1 occ:0.33 O B:HOH203 2.2 32.9 1.0 ZN B:ZN201 2.2 13.9 0.3 O B:HOH238 2.3 45.4 1.0 NE2 B:HIS10 3.6 14.9 1.0 CD2 B:HIS10 4.1 13.5 1.0 CE1 B:HIS10 4.7 16.3 1.0

Chlorine binding site 2 out of 2 in the Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Enhancing the Activity of Insulin at Receptor Edge: Crystal Structure and Photo-Cross-Linking of A8 Analogues within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl302 b:11.0 occ:0.33 ZN D:ZN301 2.3 12.8 0.3 O D:HOH304 3.0 43.2 0.3 NE2 D:HIS10 3.6 3.4 1.0 CB D:LEU6 3.8 14.7 1.0 CD1 D:LEU6 4.1 14.2 1.0 CD2 D:HIS10 4.1 5.4 1.0 CG D:LEU6 4.5 14.0 1.0 CE1 D:HIS10 4.7 2.9 1.0 C D:LEU6 4.8 14.9 1.0 CA D:LEU6 4.8 14.3 1.0 O D:LEU6 4.9 14.4 1.0

Z.Wan, B.Xu, K.Huang, Y.C.Chu, B.Li, S.H.Nakagawa, Y.Qu, S.Q.Hu, P.G.Katsoyannis, M.A.Weiss. Enhancing the Activity of Insulin at the Receptor Interface: Crystal Structure and Photo-Cross-Linking of A8 Analogues. Biochemistry V. 43 16119 2004.
ISSN: ISSN 0006-2960
PubMed: 15610006
DOI: 10.1021/BI048223F