Chlorine in PDB 1s1t: Crystal Structure of L100I Mutant Hiv-1 Reverse Transcriptase in Complex with Uc-781

All present enzymatic activity of Crystal Structure of L100I Mutant Hiv-1 Reverse Transcriptase in Complex with Uc-781:
2.7.7.49;

The structure of Crystal Structure of L100I Mutant Hiv-1 Reverse Transcriptase in Complex with Uc-781, PDB code: 1s1t was solved by J.Ren, C.E.Nichols, P.P.Chamberlain, D.K.Stammers, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.42 / 2.40
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	137.510, 109.380, 72.150, 90.00, 90.00, 90.00
R / Rfree (%)	20.6 / 27.4

The binding sites of Chlorine atom in the Crystal Structure of L100I Mutant Hiv-1 Reverse Transcriptase in Complex with Uc-781 (pdb code 1s1t). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of L100I Mutant Hiv-1 Reverse Transcriptase in Complex with Uc-781, PDB code: 1s1t:

Chlorine binding site 1 out of 1 in the Crystal Structure of L100I Mutant Hiv-1 Reverse Transcriptase in Complex with Uc-781


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of L100I Mutant Hiv-1 Reverse Transcriptase in Complex with Uc-781 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl999 b:43.2 occ:1.00 CL A:UC1999 0.0 43.2 1.0 C4 A:UC1999 1.7 33.0 1.0 C5 A:UC1999 2.7 43.5 1.0 C3 A:UC1999 2.7 30.4 1.0 OB A:UC1999 3.1 26.6 1.0 O A:LEU234 3.3 41.3 1.0 CD2 A:PHE227 3.5 42.8 1.0 C A:LEU234 3.6 47.1 1.0 O A:HIS235 3.6 58.5 1.0 CB A:LEU234 3.6 42.5 1.0 C A:HIS235 3.7 54.8 1.0 CE2 A:PHE227 3.9 48.3 1.0 C6 A:UC1999 4.0 35.1 1.0 N A:PRO236 4.0 55.0 1.0 C2 A:UC1999 4.0 31.5 1.0 N A:HIS235 4.0 46.8 1.0 OH A:TYR318 4.1 34.2 1.0 CA A:PRO236 4.2 47.6 1.0 CA A:LEU234 4.2 44.8 1.0 CA A:HIS235 4.3 50.5 1.0 CG2 A:VAL106 4.4 26.2 1.0 CC A:UC1999 4.5 33.3 1.0 C1 A:UC1999 4.5 38.3 1.0 CB A:VAL106 4.6 32.2 1.0 CG A:PHE227 4.7 46.6 1.0 CG1 A:VAL106 4.7 25.6 1.0 CD A:PRO236 4.7 56.1 1.0 CG A:LEU234 4.9 43.1 1.0

J.Ren, C.E.Nichols, P.P.Chamberlain, K.L.Weaver, S.A.Short, D.K.Stammers. Crystal Structures of Hiv-1 Reverse Transcriptases Mutated at Codons 100, 106 and 108 and Mechanisms of Resistance to Non-Nucleoside Inhibitors J.Mol.Biol. V. 336 569 2004.
ISSN: ISSN 0022-2836
PubMed: 15095972
DOI: 10.1016/J.JMB.2003.12.055