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Chlorine in PDB 1s6p: Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943
Enzymatic activity of Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943
All present enzymatic activity of Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943:
2.7.7.49;
2.7.7.49;
Protein crystallography data
The structure of Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943, PDB code: 1s6p
was solved by
K.Das,
E.Arnold,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 2.90 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 226.700, 67.400, 104.300, 90.00, 107.00, 90.00 |
| R / Rfree (%) | 24.5 / 31.2 |
Other elements in 1s6p:
The structure of Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943 also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943
(pdb code 1s6p). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943, PDB code: 1s6p:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943, PDB code: 1s6p:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 1s6p
Go back to
Chlorine Binding Sites List in 1s6p
Chlorine binding site 1 out
of 2 in the Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943 within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 1s6p
Go back to
Chlorine Binding Sites List in 1s6p
Chlorine binding site 2 out
of 2 in the Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943 within 5.0Å range:
|
Reference:
K.Das,
A.D.Clark Jr.,
P.Lewi,
J.Heeres,
M.Dejonge,
L.Koymans,
H.Vinkers,
F.Daeyaert,
D.W.Ludovici,
M.J.Kukla,
B.Decorte,
R.W.Kavash,
C.Y.Ho,
H.Ye,
M.Lichtenstein,
K.Andries,
R.Pauwles,
M.-P.Debethune,
P.L.Boyer,
P.Clark,
S.H.Hughes,
P.A.Janssen,
E.Arnold.
Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-Nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective Against Wild-Type and Drug-Resistant Hiv-1 Variants J.Med.Chem. V. 47 2550 2004.
ISSN: ISSN 0022-2623
PubMed: 15115397
DOI: 10.1021/JM030558S
Page generated: Sat Jul 20 02:04:43 2024
ISSN: ISSN 0022-2623
PubMed: 15115397
DOI: 10.1021/JM030558S
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