Chlorine in PDB 1sdt: Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site.

All present enzymatic activity of Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site.:
3.4.23.16;

The structure of Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site., PDB code: 1sdt was solved by B.Mahalingam, Y.-F.Wang, P.I.Boross, J.Tozser, J.M.Louis, R.W.Harrison, I.T.Weber, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	10.00 / 1.30
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	85.870, 58.790, 46.560, 90.00, 90.00, 90.00
R / Rfree (%)	15.5 / 19

The binding sites of Chlorine atom in the Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site. (pdb code 1sdt). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site., PDB code: 1sdt:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:14.2 occ:1.00 O A:HOH430 2.9 30.4 1.0 N A:THR74 3.2 9.6 1.0 ND2 A:ASN88 3.3 9.3 1.0 CA A:GLY73 3.8 10.2 1.0 CB A:THR74 3.8 10.1 1.0 CB A:ASN88 3.8 9.0 1.0 OG1 A:THR74 3.8 13.4 1.0 C A:GLY73 4.0 9.7 1.0 CG A:ASN88 4.1 8.5 1.0 CA A:THR74 4.1 8.5 1.0 O A:HOH321 4.3 17.0 1.0 O A:ASN88 4.7 9.6 1.0 O A:THR74 4.7 9.8 1.0 O A:HOH454 4.8 30.4 1.0 CA A:ASN88 4.9 8.6 1.0 C A:THR74 5.0 8.7 1.0 C A:ASN88 5.0 8.1 1.0

Chlorine binding site 2 out of 2 in the Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site. within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl500 b:16.7 occ:1.00 O B:HOH386 3.2 30.2 1.0 O A:HOH311 3.3 12.4 1.0 NE1 B:TRP106 3.3 11.0 1.0 CZ2 B:TRP106 3.8 10.8 1.0 CE2 B:TRP106 3.9 10.7 1.0 CG2 B:THR104 4.3 18.1 1.0 CD1 B:TRP106 4.5 11.0 1.0 O B:HOH406 4.8 34.0 1.0 CB B:THR104 4.9 13.0 1.0

B.Mahalingam, Y.-F.Wang, P.I.Boross, J.Tozser, J.M.Louis, R.W.Harrison, I.T.Weber. Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in the Indinavir-Binding Site Eur.J.Biochem. V. 271 1516 2004.
ISSN: ISSN 0014-2956
PubMed: 15066177
DOI: 10.1111/J.1432-1033.2004.04060.X