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Chlorine in PDB 1so8: Abeta-Bound Human Abad Structure [Also Known As 3-Hydroxyacyl-Coa Dehydrogenase Type II (Type II Hadh), Endoplasmic Reticulum- Associated Amyloid Beta-Peptide Binding Protein (Erab)]

Enzymatic activity of Abeta-Bound Human Abad Structure [Also Known As 3-Hydroxyacyl-Coa Dehydrogenase Type II (Type II Hadh), Endoplasmic Reticulum- Associated Amyloid Beta-Peptide Binding Protein (Erab)]

All present enzymatic activity of Abeta-Bound Human Abad Structure [Also Known As 3-Hydroxyacyl-Coa Dehydrogenase Type II (Type II Hadh), Endoplasmic Reticulum- Associated Amyloid Beta-Peptide Binding Protein (Erab)]:
1.1.1.35;

Protein crystallography data

The structure of Abeta-Bound Human Abad Structure [Also Known As 3-Hydroxyacyl-Coa Dehydrogenase Type II (Type II Hadh), Endoplasmic Reticulum- Associated Amyloid Beta-Peptide Binding Protein (Erab)], PDB code: 1so8 was solved by J.W.Lustbader, M.Cirilli, H.Wu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.83 / 2.30
Space group P 4 3 2
Cell size a, b, c (Å), α, β, γ (°) 130.000, 130.000, 130.000, 90.00, 90.00, 90.00
R / Rfree (%) 23.1 / 26.1

Other elements in 1so8:

The structure of Abeta-Bound Human Abad Structure [Also Known As 3-Hydroxyacyl-Coa Dehydrogenase Type II (Type II Hadh), Endoplasmic Reticulum- Associated Amyloid Beta-Peptide Binding Protein (Erab)] also contains other interesting chemical elements:

Sodium (Na) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Abeta-Bound Human Abad Structure [Also Known As 3-Hydroxyacyl-Coa Dehydrogenase Type II (Type II Hadh), Endoplasmic Reticulum- Associated Amyloid Beta-Peptide Binding Protein (Erab)] (pdb code 1so8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Abeta-Bound Human Abad Structure [Also Known As 3-Hydroxyacyl-Coa Dehydrogenase Type II (Type II Hadh), Endoplasmic Reticulum- Associated Amyloid Beta-Peptide Binding Protein (Erab)], PDB code: 1so8:

Chlorine binding site 1 out of 1 in 1so8

Go back to Chlorine Binding Sites List in 1so8
Chlorine binding site 1 out of 1 in the Abeta-Bound Human Abad Structure [Also Known As 3-Hydroxyacyl-Coa Dehydrogenase Type II (Type II Hadh), Endoplasmic Reticulum- Associated Amyloid Beta-Peptide Binding Protein (Erab)]


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Abeta-Bound Human Abad Structure [Also Known As 3-Hydroxyacyl-Coa Dehydrogenase Type II (Type II Hadh), Endoplasmic Reticulum- Associated Amyloid Beta-Peptide Binding Protein (Erab)] within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl303

b:20.3
occ:1.00
 O A:HOH570 3.1 35.7 1.0
N A:GLY173 3.2 20.1 1.0
N A:SER155 3.3 17.5 1.0
N A:ILE175 3.5 22.2 1.0
CB A:ALA154 3.7 17.9 1.0
N A:VAL176 3.7 22.0 1.0
N A:GLY174 3.7 22.0 1.0
CA A:ALA154 3.8 17.7 1.0
CB A:ILE175 3.8 24.6 1.0
CA A:GLY173 3.8 20.6 1.0
C A:GLY173 3.9 22.2 1.0
N A:LYS172 4.0 20.4 1.0
O A:SER155 4.0 21.6 1.0
CG2 A:VAL176 4.0 24.4 1.0
C A:ALA154 4.0 19.1 1.0
CA A:ILE175 4.1 23.3 1.0
CB A:SER171 4.1 25.7 1.0
C A:LYS172 4.2 21.2 1.0
CA A:SER155 4.3 21.1 1.0
CB A:LYS172 4.3 20.2 1.0
CB A:SER155 4.3 21.0 1.0
CB A:VAL176 4.4 23.6 1.0
C A:GLY174 4.4 24.0 1.0
CA A:LYS172 4.4 21.7 1.0
CG1 A:ILE175 4.4 23.9 1.0
C A:ILE175 4.4 23.8 1.0
CA A:GLY174 4.5 23.3 1.0
OG A:SER171 4.5 30.9 1.0
CA A:VAL176 4.6 23.4 1.0
O A:GLY173 4.6 23.0 1.0
CD1 A:ILE175 4.6 25.1 1.0
C A:SER155 4.6 20.4 1.0
C A:SER171 4.6 21.6 1.0
OG A:SER155 4.9 25.7 1.0
CA A:SER171 4.9 24.4 1.0
CG2 A:ILE175 4.9 21.3 1.0

Reference:

J.W.Lustbader, M.Cirilli, C.Lin, H.W.Xu, K.Takuma, N.Wang, C.Caspersen, X.Chen, S.Pollak, M.Chaney, F.Trinchese, F.Gunn-Moore, L.F.Lue, D.G.Walker, P.Kuppusamy, Z.L.Zewier, O.Arancio, D.Stern, S.S.Yan, H.Wu. Abad Directly Links Abeta to Mitochondrial Toxicity in Alzheimer'S Disease. Science V. 304 448 2004.
ISSN: ISSN 0036-8075
PubMed: 15087549
DOI: 10.1126/SCIENCE.1091230
Page generated: Sat Jul 20 02:14:32 2024

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