Chlorine in PDB 1suo: Structure of Mammalian Cytochrome P450 2B4 with Bound 4-(4- Chlorophenyl)Imidazole

Enzymatic activity of Structure of Mammalian Cytochrome P450 2B4 with Bound 4-(4- Chlorophenyl)Imidazole

All present enzymatic activity of Structure of Mammalian Cytochrome P450 2B4 with Bound 4-(4- Chlorophenyl)Imidazole:
1.14.14.1;

Protein crystallography data

The structure of Structure of Mammalian Cytochrome P450 2B4 with Bound 4-(4- Chlorophenyl)Imidazole, PDB code: 1suo was solved by E.E.Scott, M.A.White, Y.A.He, E.F.Johnson, C.D.Stout, J.R.Halpert, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	49.00 / 1.90
*Space group*	P 6₃ 2 2
*Cell size a, b, c (Å), α, β, γ (°)*	233.386, 233.386, 56.380, 90.00, 90.00, 120.00
*R / R_free (%)*	21.5 / 23.9

Other elements in 1suo:

The structure of Structure of Mammalian Cytochrome P450 2B4 with Bound 4-(4- Chlorophenyl)Imidazole also contains other interesting chemical elements:

Iron

(Fe)

1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Mammalian Cytochrome P450 2B4 with Bound 4-(4- Chlorophenyl)Imidazole (pdb code 1suo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Mammalian Cytochrome P450 2B4 with Bound 4-(4- Chlorophenyl)Imidazole, PDB code: 1suo:

Chlorine binding site 1 out of 1 in 1suo

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Chlorine Binding Sites List in 1suo

Chlorine binding site 1 out of 1 in the Structure of Mammalian Cytochrome P450 2B4 with Bound 4-(4- Chlorophenyl)Imidazole

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Mammalian Cytochrome P450 2B4 with Bound 4-(4- Chlorophenyl)Imidazole within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl600 b:29.8 occ:1.00	CL	A:CPZ600	0.0	29.8	1.0
	C9	A:CPZ600	1.7	45.3	1.0
	C8	A:CPZ600	2.7	41.0	1.0
	C10	A:CPZ600	2.7	43.2	1.0
	CG1	A:ILE101	3.6	47.8	1.0
	CE2	A:PHE297	3.8	68.5	1.0
	CZ	A:PHE115	3.9	41.2	1.0
	C7	A:CPZ600	4.0	41.8	1.0
	C11	A:CPZ600	4.0	42.0	1.0
	CZ	A:PHE297	4.0	61.0	1.0
	CG2	A:VAL477	4.1	41.3	1.0
	CB	A:ILE101	4.1	47.2	1.0
	CG2	A:ILE101	4.3	44.0	1.0
	C6	A:CPZ600	4.5	39.1	1.0
	CG1	A:VAL477	4.5	46.5	1.0
	CD1	A:ILE101	4.6	53.2	1.0
	CG2	A:VAL104	4.7	41.8	1.0
	CE2	A:PHE115	4.7	41.6	1.0
	CB	A:VAL477	4.8	42.9	1.0
	CE1	A:PHE115	4.8	44.0	1.0
	CG1	A:VAL367	4.9	41.0	1.0
	CD2	A:PHE297	5.0	56.9	1.0

Reference:

E.E.Scott, M.A.White, Y.A.He, E.F.Johnson, C.D.Stout, J.R.Halpert. Structure of Mammalian Cytochrome P450 2B4 Complexed with 4-(4-Chlorophenyl)Imidazole at 1.9 {Angstrom} Resolution: Insight Into the Range of P450 Conformations and Coordination of Redox Partner Binding. J.Biol.Chem. V. 279 27294 2004.
ISSN: ISSN 0021-9258
PubMed: 15100217
DOI: 10.1074/JBC.M403349200

Page generated: Sat Dec 12 08:49:17 2020

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