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Chlorine in PDB 1sv9: Crystal Structure of the Complex Formed Between Groupii Phospholipase A2 and Anti-Inflammatory Agent 2-[(2,6- Dichlorophenyl)Amino] Benzeneacetic Acid at 2.7A Resolution

Enzymatic activity of Crystal Structure of the Complex Formed Between Groupii Phospholipase A2 and Anti-Inflammatory Agent 2-[(2,6- Dichlorophenyl)Amino] Benzeneacetic Acid at 2.7A Resolution

All present enzymatic activity of Crystal Structure of the Complex Formed Between Groupii Phospholipase A2 and Anti-Inflammatory Agent 2-[(2,6- Dichlorophenyl)Amino] Benzeneacetic Acid at 2.7A Resolution:
3.1.1.4;

Protein crystallography data

The structure of Crystal Structure of the Complex Formed Between Groupii Phospholipase A2 and Anti-Inflammatory Agent 2-[(2,6- Dichlorophenyl)Amino] Benzeneacetic Acid at 2.7A Resolution, PDB code: 1sv9 was solved by R.Senthil Kumar, N.Singh, A.S.Ethayathulla, R.Prem Kumar, S.Sharma, T.P.Singh, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 18.76 / 2.71
Space group P 43
Cell size a, b, c (Å), α, β, γ (°) 53.050, 53.050, 48.430, 90.00, 90.00, 90.00
R / Rfree (%) 19.6 / 23.8

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Complex Formed Between Groupii Phospholipase A2 and Anti-Inflammatory Agent 2-[(2,6- Dichlorophenyl)Amino] Benzeneacetic Acid at 2.7A Resolution (pdb code 1sv9). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the Complex Formed Between Groupii Phospholipase A2 and Anti-Inflammatory Agent 2-[(2,6- Dichlorophenyl)Amino] Benzeneacetic Acid at 2.7A Resolution, PDB code: 1sv9:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 1sv9

Go back to Chlorine Binding Sites List in 1sv9
Chlorine binding site 1 out of 2 in the Crystal Structure of the Complex Formed Between Groupii Phospholipase A2 and Anti-Inflammatory Agent 2-[(2,6- Dichlorophenyl)Amino] Benzeneacetic Acid at 2.7A Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Complex Formed Between Groupii Phospholipase A2 and Anti-Inflammatory Agent 2-[(2,6- Dichlorophenyl)Amino] Benzeneacetic Acid at 2.7A Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl701

b:63.7
occ:1.00
 CL2 A:DIF701 0.0 63.7 1.0
C2 A:DIF701 1.7 63.9 1.0
C1 A:DIF701 2.6 64.1 1.0
C3 A:DIF701 2.8 64.6 1.0
C9 A:DIF701 3.3 71.2 1.0
N1 A:DIF701 3.5 67.3 1.0
O A:GLY30 3.8 48.6 1.0
C8 A:DIF701 3.8 70.0 1.0
C6 A:DIF701 3.8 64.4 1.0
C4 A:DIF701 4.0 64.0 1.0
C10 A:DIF701 4.3 71.7 1.0
CD2 A:LEU2 4.3 32.7 1.0
C5 A:DIF701 4.4 64.1 1.0
C A:GLY30 4.7 48.3 1.0
CA A:GLY30 4.7 44.9 1.0
CG A:LEU2 5.0 30.2 1.0

Chlorine binding site 2 out of 2 in 1sv9

Go back to Chlorine Binding Sites List in 1sv9
Chlorine binding site 2 out of 2 in the Crystal Structure of the Complex Formed Between Groupii Phospholipase A2 and Anti-Inflammatory Agent 2-[(2,6- Dichlorophenyl)Amino] Benzeneacetic Acid at 2.7A Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Complex Formed Between Groupii Phospholipase A2 and Anti-Inflammatory Agent 2-[(2,6- Dichlorophenyl)Amino] Benzeneacetic Acid at 2.7A Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl701

b:61.7
occ:1.00
 CL4 A:DIF701 0.0 61.7 1.0
C4 A:DIF701 1.8 64.0 1.0
N1 A:DIF701 2.7 67.3 1.0
C3 A:DIF701 2.7 64.6 1.0
C5 A:DIF701 2.9 64.1 1.0
C8 A:DIF701 3.7 70.0 1.0
CB A:ALA18 3.7 22.9 1.0
CD2 A:PHE5 3.8 16.9 1.0
CD1 A:LEU2 4.0 30.6 1.0
C2 A:DIF701 4.0 63.9 1.0
C6 A:DIF701 4.2 64.4 1.0
CG A:LEU2 4.3 30.2 1.0
C13 A:DIF701 4.4 72.2 1.0
CE2 A:PHE5 4.4 17.1 1.0
C7 A:DIF701 4.4 71.3 1.0
O A:LEU2 4.5 29.0 1.0
N A:GLY6 4.5 20.4 1.0
CA A:GLY6 4.6 20.7 1.0
C1 A:DIF701 4.6 64.1 1.0
C9 A:DIF701 4.6 71.2 1.0
CG A:PHE5 4.7 15.9 1.0
CB A:PHE5 4.8 18.8 1.0
CA A:ALA18 4.9 25.0 1.0

Reference:

R.Senthil Kumar, N.Singh, A.S.Ethayathulla, R.Prem Kumar, S.Sharma, T.P.Singh. Crystal Structure of the Complex Formed Between Group II Phospholipase A2 and Anti-Inflammatory Agent 2-[(2,6-Dichlorophenyl)Amino] Benzeneacetic Acid at 2.7A Resolution To Be Published.
Page generated: Sat Dec 12 08:49:18 2020

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