Chlorine in PDB 1t8a: Use of Sequence Duplication to Engineer A Ligand-Triggered Long- Distance Molecular Switch in T4 Lysozyme

Enzymatic activity of Use of Sequence Duplication to Engineer A Ligand-Triggered Long- Distance Molecular Switch in T4 Lysozyme

All present enzymatic activity of Use of Sequence Duplication to Engineer A Ligand-Triggered Long- Distance Molecular Switch in T4 Lysozyme:
3.2.1.17;

Protein crystallography data

The structure of Use of Sequence Duplication to Engineer A Ligand-Triggered Long- Distance Molecular Switch in T4 Lysozyme, PDB code: 1t8a was solved by M.S.Yousef, W.A.Baase, B.W.Matthews, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	30.00 / 2.00
*Space group*	P 3₂ 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	60.401, 60.401, 96.190, 90.00, 90.00, 120.00
*R / R_free (%)*	21.8 / 25.1

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Use of Sequence Duplication to Engineer A Ligand-Triggered Long- Distance Molecular Switch in T4 Lysozyme (pdb code 1t8a). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Use of Sequence Duplication to Engineer A Ligand-Triggered Long- Distance Molecular Switch in T4 Lysozyme, PDB code: 1t8a:

Chlorine binding site 1 out of 1 in 1t8a

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Chlorine Binding Sites List in 1t8a

Chlorine binding site 1 out of 1 in the Use of Sequence Duplication to Engineer A Ligand-Triggered Long- Distance Molecular Switch in T4 Lysozyme

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Use of Sequence Duplication to Engineer A Ligand-Triggered Long- Distance Molecular Switch in T4 Lysozyme within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl500 b:22.9 occ:0.50	O	A:HOH425	2.9	22.8	1.0
	O	A:HOH413	3.2	23.6	1.0
	CE1	A:HIS31	3.6	23.2	1.0
	CB	A:ALA60	3.7	21.1	1.0
	NE2	A:HIS31	4.0	27.3	1.0
	O	A:HOH447	4.0	36.8	1.0
	CA	A:ALA60	4.3	24.2	1.0
	NE2	A:GLN80	4.4	20.6	1.0
	O	A:HOH440	4.5	27.9	1.0
	CD2	A:LEU77	4.7	23.4	1.0
	O	A:HOH450	4.7	32.9	1.0
	ND1	A:HIS31	4.8	18.9	1.0
	OD1	A:ASP81	4.9	17.9	1.0

Reference:

M.S.Yousef, W.A.Baase, B.W.Matthews. Use of Sequence Duplication to Engineer A Ligand-Triggered, Long-Distance Molecular Switch in T4 Lysozyme. Proc.Natl.Acad.Sci.Usa V. 101 11583 2004.
ISSN: ISSN 0027-8424
PubMed: 15286283
DOI: 10.1073/PNAS.0404482101

Page generated: Sat Dec 12 08:49:45 2020

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