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Chlorine in PDB 1tl7: Complex of Gs- with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'(3')-O-(N- Methylanthraniloyl)-Guanosine 5'-Triphosphate and Mn

Enzymatic activity of Complex of Gs- with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'(3')-O-(N- Methylanthraniloyl)-Guanosine 5'-Triphosphate and Mn

All present enzymatic activity of Complex of Gs- with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'(3')-O-(N- Methylanthraniloyl)-Guanosine 5'-Triphosphate and Mn:
4.6.1.1;

Protein crystallography data

The structure of Complex of Gs- with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'(3')-O-(N- Methylanthraniloyl)-Guanosine 5'-Triphosphate and Mn, PDB code: 1tl7 was solved by T.C.Mou, A.Gille, R.J.Seifert, S.R.Sprang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 14.99 / 2.80
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 118.230, 133.600, 70.350, 90.00, 90.00, 90.00
R / Rfree (%) 25.4 / 29.8

Other elements in 1tl7:

The structure of Complex of Gs- with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'(3')-O-(N- Methylanthraniloyl)-Guanosine 5'-Triphosphate and Mn also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Manganese (Mn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Complex of Gs- with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'(3')-O-(N- Methylanthraniloyl)-Guanosine 5'-Triphosphate and Mn (pdb code 1tl7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Complex of Gs- with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'(3')-O-(N- Methylanthraniloyl)-Guanosine 5'-Triphosphate and Mn, PDB code: 1tl7:

Chlorine binding site 1 out of 1 in 1tl7

Go back to Chlorine Binding Sites List in 1tl7
Chlorine binding site 1 out of 1 in the Complex of Gs- with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'(3')-O-(N- Methylanthraniloyl)-Guanosine 5'-Triphosphate and Mn


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Complex of Gs- with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with 2'(3')-O-(N- Methylanthraniloyl)-Guanosine 5'-Triphosphate and Mn within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl404

b:49.9
occ:1.00
 N C:ALA249 3.4 20.5 1.0
CB C:ALA249 3.6 21.9 1.0
CB C:ALA48 3.6 31.5 1.0
CB C:SER51 3.9 23.3 1.0
CB C:ALA269 4.0 33.5 1.0
CA C:ALA249 4.1 21.5 1.0
O C:ARG265 4.1 33.9 1.0
CA C:SER51 4.4 22.0 1.0
C C:VAL248 4.4 21.1 1.0
CA C:VAL248 4.4 19.6 1.0
CA C:ALA48 4.6 32.1 1.0
CG1 C:VAL248 4.7 15.1 1.0
O C:GLY49 4.8 40.0 1.0
N C:ALA48 4.8 30.5 1.0
O C:ALA249 4.8 32.5 1.0
C C:ALA249 4.8 25.9 1.0
C C:ARG265 4.9 33.7 1.0
CA C:ALA269 4.9 34.1 1.0
N C:SER51 5.0 27.3 1.0
C C:ALA48 5.0 34.9 1.0

Reference:

T.C.Mou, A.Gille, D.A.Fancy, R.Seifert, S.R.Sprang. Structural Basis For the Inhibition of Mammalian Membrane Adenylyl Cyclase By 2 '(3')-O-(N-Methylanthraniloyl)-Guanosine 5 '-Triphosphate. J.Biol.Chem. V. 280 7253 2005.
ISSN: ISSN 0021-9258
PubMed: 15591060
DOI: 10.1074/JBC.M409076200
Page generated: Thu Jul 10 19:37:07 2025

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