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Chlorine in PDB 1tnb: Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Substrate Kksktkcvif Peptide Derived From TC21

Enzymatic activity of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Substrate Kksktkcvif Peptide Derived From TC21

All present enzymatic activity of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Substrate Kksktkcvif Peptide Derived From TC21:
2.5.1.59;

Protein crystallography data

The structure of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Substrate Kksktkcvif Peptide Derived From TC21, PDB code: 1tnb was solved by T.S.Reid, K.L.Terry, P.J.Casey, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.66 / 2.85
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 271.130, 266.720, 185.141, 90.00, 131.68, 90.00
R / Rfree (%) 18.9 / 21

Other elements in 1tnb:

The structure of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Substrate Kksktkcvif Peptide Derived From TC21 also contains other interesting chemical elements:

Zinc (Zn) 6 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Substrate Kksktkcvif Peptide Derived From TC21 (pdb code 1tnb). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Substrate Kksktkcvif Peptide Derived From TC21, PDB code: 1tnb:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 1tnb

Go back to Chlorine Binding Sites List in 1tnb
Chlorine binding site 1 out of 3 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Substrate Kksktkcvif Peptide Derived From TC21


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Substrate Kksktkcvif Peptide Derived From TC21 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl379

b:37.0
occ:1.00
 N D:GLN287 3.2 31.7 1.0
N D:PHE286 3.2 32.9 1.0
C D:LYS284 3.5 35.1 1.0
N D:ILE285 3.5 32.5 1.0
CG D:GLN287 3.6 36.2 1.0
CB D:GLN287 3.6 32.2 1.0
O D:LYS284 3.8 36.2 1.0
CA D:LYS284 3.8 36.6 1.0
CB D:PHE286 3.9 28.2 1.0
C D:ILE285 3.9 32.7 1.0
CA D:PHE286 3.9 31.4 1.0
NE2 D:GLN287 3.9 38.4 1.0
CA D:GLN287 4.0 33.4 1.0
C D:PHE286 4.0 31.6 1.0
CA D:ILE285 4.0 31.9 1.0
CD D:GLN287 4.1 39.5 1.0
CD D:LYS281 4.2 38.2 1.0
O D:LYS281 4.5 31.6 1.0
CA D:LYS281 4.5 33.9 1.0
O D:LEU280 4.6 35.9 1.0
N D:LYS284 4.7 37.4 1.0
NZ D:LYS281 4.7 42.2 1.0
CB D:LYS284 4.8 37.7 1.0
CE D:LYS281 4.8 42.4 1.0
O D:ILE285 4.9 33.4 1.0
C D:LYS281 5.0 31.6 1.0

Chlorine binding site 2 out of 3 in 1tnb

Go back to Chlorine Binding Sites List in 1tnb
Chlorine binding site 2 out of 3 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Substrate Kksktkcvif Peptide Derived From TC21


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Substrate Kksktkcvif Peptide Derived From TC21 within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl379

b:35.6
occ:1.00
 N F:GLN287 3.4 30.7 1.0
N F:PHE286 3.4 31.0 1.0
C F:LYS284 3.6 31.8 1.0
N F:ILE285 3.7 31.1 1.0
CB F:GLN287 3.8 31.9 1.0
CA F:LYS284 3.8 32.2 1.0
CG F:GLN287 3.9 33.4 1.0
NE2 F:GLN287 3.9 32.0 1.0
O F:LYS284 3.9 32.2 1.0
CB F:PHE286 3.9 31.2 1.0
CD F:LYS281 4.0 36.9 1.0
CA F:PHE286 4.0 31.1 1.0
C F:ILE285 4.1 31.1 1.0
CA F:GLN287 4.1 31.7 1.0
C F:PHE286 4.2 30.3 1.0
CA F:ILE285 4.2 30.4 1.0
CD F:GLN287 4.2 35.0 1.0
O F:LYS281 4.4 31.9 1.0
CA F:LYS281 4.5 31.7 1.0
NZ F:LYS281 4.7 40.5 1.0
CE F:LYS281 4.7 38.4 1.0
O F:LEU280 4.7 33.0 1.0
N F:LYS284 4.8 32.1 1.0
CB F:LYS284 4.8 34.2 1.0
C F:LYS281 4.9 31.7 1.0

Chlorine binding site 3 out of 3 in 1tnb

Go back to Chlorine Binding Sites List in 1tnb
Chlorine binding site 3 out of 3 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Substrate Kksktkcvif Peptide Derived From TC21


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Substrate Kksktkcvif Peptide Derived From TC21 within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Cl379

b:47.7
occ:1.00
 N H:PHE286 3.1 39.3 1.0
N H:GLN287 3.2 39.8 1.0
C H:LYS284 3.5 41.1 1.0
N H:ILE285 3.5 40.0 1.0
CB H:GLN287 3.7 40.3 1.0
CB H:PHE286 3.7 39.4 1.0
CA H:PHE286 3.8 39.4 1.0
CA H:LYS284 3.8 41.6 1.0
CG H:GLN287 3.9 44.1 1.0
C H:ILE285 3.9 38.7 1.0
O H:LYS284 3.9 41.1 1.0
C H:PHE286 4.0 38.8 1.0
NE2 H:GLN287 4.0 46.2 1.0
CA H:ILE285 4.0 39.0 1.0
CA H:GLN287 4.0 40.6 1.0
NZ H:LYS281 4.1 49.7 1.0
CD H:LYS281 4.1 45.8 1.0
CD H:GLN287 4.3 46.0 1.0
CA H:LYS281 4.3 41.6 1.0
O H:LYS281 4.4 43.0 1.0
CE H:LYS281 4.4 48.4 1.0
O H:LEU280 4.5 42.6 1.0
N H:LYS284 4.7 43.0 1.0
C H:LYS281 4.9 40.9 1.0
O H:ILE285 4.9 39.0 1.0
CB H:LYS284 4.9 40.5 1.0
CG H:PHE286 5.0 39.8 1.0

Reference:

T.S.Reid, K.L.Terry, P.J.Casey, L.S.Beese. Crystallographic Analysis of Caax Prenyltransferases Complexed with Substrates Defines Rules of Protein Substrate Selectivity. J.Mol.Biol. V. 343 417 2004.
ISSN: ISSN 0022-2836
PubMed: 15451670
DOI: 10.1016/J.JMB.2004.08.056
Page generated: Sat Dec 12 08:50:12 2020

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