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Chlorine in PDB 1tnu: Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Gcincckvl Peptide Derived From Rhob

Enzymatic activity of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Gcincckvl Peptide Derived From Rhob

All present enzymatic activity of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Gcincckvl Peptide Derived From Rhob:
2.5.1.59;

Protein crystallography data

The structure of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Gcincckvl Peptide Derived From Rhob, PDB code: 1tnu was solved by T.S.Reid, K.L.Terry, P.J.Casey, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.94 / 2.70
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 270.359, 266.551, 184.818, 90.00, 131.58, 90.00
R / Rfree (%) 19.3 / 21.2

Other elements in 1tnu:

The structure of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Gcincckvl Peptide Derived From Rhob also contains other interesting chemical elements:

Zinc (Zn) 6 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Gcincckvl Peptide Derived From Rhob (pdb code 1tnu). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Gcincckvl Peptide Derived From Rhob, PDB code: 1tnu:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 1tnu

Go back to Chlorine Binding Sites List in 1tnu
Chlorine binding site 1 out of 3 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Gcincckvl Peptide Derived From Rhob


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Gcincckvl Peptide Derived From Rhob within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl379

b:59.9
occ:1.00
N D:GLN287 3.2 47.3 1.0
N D:PHE286 3.2 48.6 1.0
C D:LYS284 3.5 50.8 1.0
N D:ILE285 3.6 48.2 1.0
CG D:GLN287 3.7 51.9 1.0
CB D:GLN287 3.7 47.9 1.0
CB D:PHE286 3.8 43.9 1.0
CA D:PHE286 3.8 47.0 1.0
CA D:LYS284 3.8 52.2 1.0
NE2 D:GLN287 3.9 54.0 1.0
O D:LYS284 3.9 51.9 1.0
C D:ILE285 3.9 48.4 1.0
C D:PHE286 3.9 47.2 1.0
CA D:GLN287 4.0 49.0 1.0
CA D:ILE285 4.0 47.5 1.0
CD D:GLN287 4.1 55.1 1.0
CD D:LYS281 4.3 53.9 1.0
CA D:LYS281 4.5 49.5 1.0
O D:LYS281 4.5 47.2 1.0
O D:LEU280 4.6 51.6 1.0
N D:LYS284 4.8 53.0 1.0
CE D:LYS281 4.8 58.0 1.0
O D:ILE285 4.8 49.0 1.0
CB D:LYS284 4.9 53.3 1.0
CG D:PHE286 5.0 41.5 1.0
C D:LYS281 5.0 47.3 1.0

Chlorine binding site 2 out of 3 in 1tnu

Go back to Chlorine Binding Sites List in 1tnu
Chlorine binding site 2 out of 3 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Gcincckvl Peptide Derived From Rhob


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Gcincckvl Peptide Derived From Rhob within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl379

b:55.2
occ:1.00
N F:PHE286 3.4 45.4 1.0
N F:GLN287 3.4 45.1 1.0
C F:LYS284 3.6 46.1 1.0
N F:ILE285 3.7 45.5 1.0
CG F:GLN287 3.8 47.8 1.0
CA F:LYS284 3.8 46.6 1.0
CB F:GLN287 3.8 46.2 1.0
NE2 F:GLN287 3.8 46.4 1.0
O F:LYS284 3.9 46.6 1.0
CB F:PHE286 3.9 45.6 1.0
CA F:PHE286 4.0 45.5 1.0
C F:ILE285 4.1 45.4 1.0
C F:PHE286 4.2 44.7 1.0
CA F:GLN287 4.2 46.1 1.0
CD F:GLN287 4.2 49.3 1.0
CA F:ILE285 4.2 44.8 1.0
CD F:LYS281 4.3 51.3 1.0
O F:LYS281 4.4 46.3 1.0
CA F:LYS281 4.5 46.0 1.0
CE F:LYS281 4.6 52.8 1.0
O F:LEU280 4.7 47.4 1.0
N F:LYS284 4.7 46.5 1.0
CB F:LYS284 4.8 48.6 1.0
CG F:LYS281 4.9 47.7 1.0
C F:LYS281 5.0 46.1 1.0

Chlorine binding site 3 out of 3 in 1tnu

Go back to Chlorine Binding Sites List in 1tnu
Chlorine binding site 3 out of 3 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Gcincckvl Peptide Derived From Rhob


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Gcincckvl Peptide Derived From Rhob within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Cl379

b:62.9
occ:1.00
N H:PHE286 3.2 53.5 1.0
N H:GLN287 3.3 54.0 1.0
C H:LYS284 3.5 55.3 1.0
N H:ILE285 3.6 54.2 1.0
CB H:PHE286 3.8 53.5 1.0
CA H:LYS284 3.8 55.8 1.0
CB H:GLN287 3.8 54.5 1.0
CG H:GLN287 3.8 58.3 1.0
CA H:PHE286 3.9 53.5 1.0
O H:LYS284 3.9 55.3 1.0
NE2 H:GLN287 3.9 60.4 1.0
C H:ILE285 4.0 52.9 1.0
C H:PHE286 4.0 52.9 1.0
CA H:ILE285 4.1 53.2 1.0
CA H:GLN287 4.1 54.8 1.0
CD H:LYS281 4.1 60.0 1.0
CD H:GLN287 4.2 60.2 1.0
CA H:LYS281 4.4 55.8 1.0
O H:LYS281 4.4 57.2 1.0
O H:LEU280 4.5 56.8 1.0
N H:LYS284 4.7 57.2 1.0
NZ H:LYS281 4.7 63.9 1.0
CE H:LYS281 4.8 62.6 1.0
CB H:LYS284 4.8 54.7 1.0
C H:LYS281 4.9 55.1 1.0
O H:ILE285 5.0 53.2 1.0

Reference:

T.S.Reid, K.L.Terry, P.J.Casey, L.S.Beese. Crystallographic Analysis of Caax Prenyltransferases Complexed with Substrates Defines Rules of Protein Substrate Selectivity. J.Mol.Biol. V. 343 417 2004.
ISSN: ISSN 0022-2836
PubMed: 15451670
DOI: 10.1016/J.JMB.2004.08.056
Page generated: Sat Dec 12 08:50:14 2020

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