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Chlorine in PDB 1tny: Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit

Enzymatic activity of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit

All present enzymatic activity of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit:
2.5.1.59;

Protein crystallography data

The structure of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit, PDB code: 1tny was solved by T.S Reid, K.L.Terry, P.J.Casey, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.91 / 2.70
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 270.947, 264.007, 184.985, 90.00, 131.72, 90.00
R / Rfree (%) 19.3 / 21.2

Other elements in 1tny:

The structure of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit also contains other interesting chemical elements:

Zinc (Zn) 6 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit (pdb code 1tny). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit, PDB code: 1tny:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in 1tny

Go back to Chlorine Binding Sites List in 1tny
Chlorine binding site 1 out of 6 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl379

b:64.0
occ:1.00
 N B:GLN287 3.3 52.1 1.0
N B:PHE286 3.3 50.7 1.0
C B:LYS284 3.6 51.2 1.0
N B:ILE285 3.7 50.7 1.0
CB B:GLN287 3.8 52.2 1.0
NE2 B:GLN287 3.8 52.4 1.0
CB B:PHE286 3.8 49.9 1.0
CA B:LYS284 3.8 51.5 1.0
CG B:GLN287 3.9 53.5 1.0
CA B:PHE286 3.9 51.2 1.0
O B:LYS284 3.9 51.8 1.0
CD B:LYS281 4.0 55.9 1.0
C B:ILE285 4.0 50.1 1.0
C B:PHE286 4.1 52.0 1.0
CA B:GLN287 4.1 52.9 1.0
CD B:GLN287 4.1 54.1 1.0
CA B:ILE285 4.2 50.0 1.0
CA B:LYS281 4.4 51.6 1.0
O B:LYS281 4.4 55.0 1.0
CE B:LYS281 4.6 58.3 1.0
O B:LEU280 4.6 49.1 1.0
NZ B:LYS281 4.7 61.1 1.0
N B:LYS284 4.8 51.8 1.0
CB B:LYS284 4.8 53.9 1.0
C B:LYS281 4.9 52.2 1.0

Chlorine binding site 2 out of 6 in 1tny

Go back to Chlorine Binding Sites List in 1tny
Chlorine binding site 2 out of 6 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl379

b:49.8
occ:1.00
 N D:GLN287 3.1 37.7 1.0
N D:PHE286 3.2 36.2 1.0
O D:HOH404 3.5 42.0 1.0
C D:LYS284 3.6 39.9 1.0
N D:ILE285 3.6 36.5 1.0
CB D:GLN287 3.7 38.7 1.0
CB D:PHE286 3.7 31.7 1.0
CG D:GLN287 3.7 44.1 1.0
CA D:PHE286 3.8 35.6 1.0
CA D:LYS284 3.9 42.2 1.0
C D:PHE286 3.9 37.0 1.0
C D:ILE285 3.9 36.1 1.0
O D:LYS284 3.9 39.5 1.0
CA D:GLN287 3.9 39.5 1.0
NE2 D:GLN287 4.1 46.6 1.0
CD D:LYS281 4.1 47.5 1.0
CA D:ILE285 4.1 35.1 1.0
CD D:GLN287 4.2 46.6 1.0
CA D:LYS281 4.4 40.3 1.0
O D:LYS281 4.5 39.4 1.0
O D:LEU280 4.6 39.6 1.0
N D:LYS284 4.8 43.6 1.0
O D:ILE285 4.9 35.0 1.0
NZ D:LYS281 4.9 54.4 1.0
CG D:PHE286 4.9 30.3 1.0
CE D:LYS281 4.9 53.5 1.0
C D:LYS281 4.9 39.4 1.0
CB D:LYS284 4.9 43.9 1.0
CG D:LYS281 5.0 45.0 1.0

Chlorine binding site 3 out of 6 in 1tny

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Chlorine binding site 3 out of 6 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl379

b:49.9
occ:1.00
 N F:GLN287 3.2 39.7 1.0
N F:PHE286 3.3 38.9 1.0
C F:LYS284 3.5 37.9 1.0
N F:ILE285 3.6 37.3 1.0
CB F:GLN287 3.7 39.8 1.0
CG F:GLN287 3.8 41.6 1.0
CA F:LYS284 3.8 38.1 1.0
CB F:PHE286 3.8 39.0 1.0
O F:LYS284 3.9 37.9 1.0
CA F:PHE286 3.9 38.5 1.0
NE2 F:GLN287 3.9 40.0 1.0
C F:ILE285 4.0 38.2 1.0
C F:PHE286 4.0 38.8 1.0
CA F:GLN287 4.0 39.6 1.0
CA F:ILE285 4.1 37.1 1.0
CD F:GLN287 4.2 42.8 1.0
CD F:LYS281 4.3 46.1 1.0
CA F:LYS281 4.4 39.0 1.0
O F:LYS281 4.5 41.3 1.0
CE F:LYS281 4.6 48.8 1.0
O F:LEU280 4.6 38.5 1.0
N F:LYS284 4.8 39.3 1.0
CB F:LYS284 4.8 37.8 1.0
CG F:LYS281 4.9 42.3 1.0
C F:LYS281 4.9 38.8 1.0
NZ F:LYS281 5.0 50.7 1.0
O F:ILE285 5.0 38.0 1.0

Chlorine binding site 4 out of 6 in 1tny

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Chlorine binding site 4 out of 6 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Cl379

b:54.5
occ:1.00
 N H:PHE286 3.1 46.2 1.0
N H:GLN287 3.2 48.4 1.0
C H:LYS284 3.4 46.1 1.0
N H:ILE285 3.5 44.3 1.0
CB H:PHE286 3.7 48.0 1.0
CA H:LYS284 3.7 47.0 1.0
CA H:PHE286 3.8 47.8 1.0
CB H:GLN287 3.8 50.0 1.0
O H:LYS284 3.8 46.4 1.0
CG H:GLN287 3.9 52.6 1.0
NE2 H:GLN287 3.9 52.0 1.0
C H:ILE285 3.9 45.1 1.0
C H:PHE286 4.0 47.8 1.0
CA H:ILE285 4.0 44.6 1.0
CA H:GLN287 4.1 49.2 1.0
CD H:LYS281 4.2 56.1 1.0
CD H:GLN287 4.3 52.8 1.0
CA H:LYS281 4.3 48.0 1.0
O H:LYS281 4.4 48.9 1.0
O H:LEU280 4.5 47.5 1.0
NZ H:LYS281 4.6 61.4 1.0
N H:LYS284 4.7 48.6 1.0
CB H:LYS284 4.8 46.5 1.0
C H:LYS281 4.8 48.1 1.0
CE H:LYS281 4.8 61.0 1.0
O H:ILE285 4.9 44.0 1.0
CG H:PHE286 5.0 48.7 1.0

Chlorine binding site 5 out of 6 in 1tny

Go back to Chlorine Binding Sites List in 1tny
Chlorine binding site 5 out of 6 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Cl379

b:68.0
occ:1.00
 N J:PHE286 3.0 51.7 1.0
N J:GLN287 3.1 56.0 1.0
C J:LYS284 3.5 52.6 1.0
N J:ILE285 3.5 50.3 1.0
CB J:PHE286 3.7 53.2 1.0
CA J:PHE286 3.7 53.9 1.0
CB J:GLN287 3.7 57.7 1.0
CA J:LYS284 3.8 53.5 1.0
C J:ILE285 3.8 50.6 1.0
O J:LYS284 3.9 53.2 1.0
CG J:GLN287 3.9 62.6 1.0
C J:PHE286 3.9 54.5 1.0
CA J:ILE285 4.0 50.0 1.0
CA J:GLN287 4.0 56.1 1.0
CD J:LYS281 4.1 60.9 1.0
NE2 J:GLN287 4.2 61.9 1.0
NZ J:LYS281 4.2 66.1 1.0
CA J:LYS281 4.3 52.2 1.0
CD J:GLN287 4.4 63.2 1.0
O J:LYS281 4.4 53.5 1.0
CE J:LYS281 4.4 63.1 1.0
O J:LEU280 4.5 52.8 1.0
N J:LYS284 4.7 54.5 1.0
O J:ILE285 4.8 50.8 1.0
CB J:LYS284 4.9 54.9 1.0
C J:LYS281 4.9 51.9 1.0
CG J:PHE286 4.9 53.7 1.0

Chlorine binding site 6 out of 6 in 1tny

Go back to Chlorine Binding Sites List in 1tny
Chlorine binding site 6 out of 6 in the Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Rat Protein Geranylgeranyltransferase Type-I Complexed with A Ggpp Analog and A Frekkffcail Peptide Derived From the Heterotrimeric G Protein Gamma-2 Subunit within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Cl379

b:47.5
occ:1.00
 N L:PHE286 3.1 33.5 1.0
N L:GLN287 3.3 36.5 1.0
C L:LYS284 3.3 39.1 1.0
N L:ILE285 3.4 36.0 1.0
CA L:LYS284 3.6 40.4 1.0
CG L:GLN287 3.7 43.1 1.0
O L:LYS284 3.7 40.9 1.0
CB L:PHE286 3.8 32.0 1.0
CA L:PHE286 3.8 34.9 1.0
C L:ILE285 3.8 34.3 1.0
NE2 L:GLN287 3.8 42.1 1.0
CB L:GLN287 3.8 37.5 1.0
CA L:ILE285 3.9 34.7 1.0
CE L:LYS281 4.0 53.3 1.0
CD L:LYS281 4.0 46.8 1.0
C L:PHE286 4.0 35.5 1.0
CD L:GLN287 4.1 42.7 1.0
CA L:GLN287 4.1 37.8 1.0
CA L:LYS281 4.3 37.1 1.0
O L:LYS281 4.3 38.8 1.0
O L:LEU280 4.4 35.9 1.0
N L:LYS284 4.5 40.6 1.0
CB L:LYS284 4.7 43.5 1.0
C L:LYS281 4.8 37.5 1.0
O L:ILE285 4.8 34.7 1.0

Reference:

T.S.Reid, K.L.Terry, P.J.Casey, L.S.Beese. Crystallographic Analysis of Caax Prenyltransferases Complexed with Substrates Defines Rules of Protein Substrate Selectivity. J.Mol.Biol. V. 343 417 2004.
ISSN: ISSN 0022-2836
PubMed: 15451670
DOI: 10.1016/J.JMB.2004.08.056
Page generated: Sat Jul 20 02:34:23 2024

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