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Chlorine in PDB 1tpk: Crystal Structure of the Kringle-2 Domain of Tissue Plasminogen Activator at 2.4-Angstroms Resolution

Enzymatic activity of Crystal Structure of the Kringle-2 Domain of Tissue Plasminogen Activator at 2.4-Angstroms Resolution

All present enzymatic activity of Crystal Structure of the Kringle-2 Domain of Tissue Plasminogen Activator at 2.4-Angstroms Resolution:
3.4.21.31;

Protein crystallography data

The structure of Crystal Structure of the Kringle-2 Domain of Tissue Plasminogen Activator at 2.4-Angstroms Resolution, PDB code: 1tpk was solved by A.M.De Vos, M.H.Ultsch, R.F.Kelley, K.Padmanabhan, A.Tulinsky, M.L.Westbrook, A.A.Kossiakoff, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 2.40
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 54.800, 63.580, 46.580, 90.00, 106.73, 90.00
R / Rfree (%) 18.4 / n/a

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Kringle-2 Domain of Tissue Plasminogen Activator at 2.4-Angstroms Resolution (pdb code 1tpk). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of the Kringle-2 Domain of Tissue Plasminogen Activator at 2.4-Angstroms Resolution, PDB code: 1tpk:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 1tpk

Go back to Chlorine Binding Sites List in 1tpk
Chlorine binding site 1 out of 3 in the Crystal Structure of the Kringle-2 Domain of Tissue Plasminogen Activator at 2.4-Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Kringle-2 Domain of Tissue Plasminogen Activator at 2.4-Angstroms Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl83

b:2.0
occ:1.00
O C:HOH90 3.0 26.3 1.0
N A:TYR35 3.2 9.8 1.0
ND2 C:ASN26 3.4 9.5 1.0
N A:VAL34 3.4 10.6 1.0
CB A:TYR35 3.6 9.0 1.0
CG A:LYS33 3.6 10.6 1.0
CD2 A:TYR35 3.7 9.1 1.0
CE1 A:HIS64 3.8 7.3 1.0
CA A:TYR35 3.9 9.4 1.0
CA A:VAL34 4.1 9.7 1.0
CB A:LYS33 4.1 10.7 1.0
C A:VAL34 4.1 10.5 1.0
CG A:TYR35 4.1 8.1 1.0
CB A:VAL34 4.2 8.3 1.0
NE2 A:HIS64 4.2 7.6 1.0
C A:LYS33 4.3 11.9 1.0
CG C:ASN26 4.3 8.8 1.0
CB C:LYS47A 4.4 4.5 1.0
OD1 C:ASN26 4.4 9.3 1.0
CA A:LYS33 4.4 11.8 1.0
CH2 A:TRP62 4.6 2.0 1.0
C A:TYR35 4.6 10.3 1.0
CG C:LYS47A 4.6 3.1 1.0
CD C:LYS47A 4.7 2.3 1.0
O A:TYR35 4.7 11.3 1.0
CE A:LYS33 4.7 9.2 1.0
O C:LYS47A 4.7 7.7 1.0
CD A:LYS33 4.8 8.9 1.0
CE2 A:TYR35 4.8 8.6 1.0
CA C:LYS47A 4.8 5.5 1.0
ND1 A:HIS64 4.9 5.8 1.0
C C:LYS47A 5.0 6.6 1.0

Chlorine binding site 2 out of 3 in 1tpk

Go back to Chlorine Binding Sites List in 1tpk
Chlorine binding site 2 out of 3 in the Crystal Structure of the Kringle-2 Domain of Tissue Plasminogen Activator at 2.4-Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Kringle-2 Domain of Tissue Plasminogen Activator at 2.4-Angstroms Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl83

b:10.1
occ:1.00
N B:TYR35 3.2 9.3 1.0
N B:VAL34 3.4 9.9 1.0
CG B:LYS33 3.5 9.6 1.0
CE1 B:HIS64 3.6 6.7 1.0
CD2 B:TYR35 3.8 9.0 1.0
CB B:VAL34 4.0 8.6 1.0
CB B:TYR35 4.0 9.1 1.0
CA B:VAL34 4.0 9.3 1.0
CB B:LYS33 4.0 10.7 1.0
C B:VAL34 4.1 9.8 1.0
CA B:TYR35 4.1 9.2 1.0
NE2 B:HIS64 4.2 6.0 1.0
C B:LYS33 4.3 10.6 1.0
CG B:TYR35 4.3 8.8 1.0
CH2 B:TRP62 4.4 2.4 1.0
CG2 B:VAL34 4.5 8.8 1.0
CA B:LYS33 4.5 11.3 1.0
O B:TYR35 4.5 9.9 1.0
ND1 B:HIS64 4.7 6.4 1.0
C B:TYR35 4.7 9.7 1.0
CE2 B:TYR35 4.8 8.4 1.0
CE B:LYS33 4.8 8.1 1.0
CD B:LYS33 4.8 8.6 1.0

Chlorine binding site 3 out of 3 in 1tpk

Go back to Chlorine Binding Sites List in 1tpk
Chlorine binding site 3 out of 3 in the Crystal Structure of the Kringle-2 Domain of Tissue Plasminogen Activator at 2.4-Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of the Kringle-2 Domain of Tissue Plasminogen Activator at 2.4-Angstroms Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl83

b:6.9
occ:1.00
O B:HOH88 3.0 7.4 1.0
ND2 B:ASN26 3.2 8.6 1.0
N C:TYR35 3.3 8.9 1.0
N C:VAL34 3.3 10.7 1.0
CE1 C:HIS64 3.5 6.6 1.0
CD2 C:TYR35 3.9 9.4 1.0
CB C:LYS33 3.9 9.7 1.0
CB C:TYR35 4.0 9.3 1.0
CA C:VAL34 4.0 9.8 1.0
NE2 C:HIS64 4.0 5.8 1.0
CB B:LYS47A 4.0 4.2 1.0
C C:LYS33 4.1 10.9 1.0
C C:VAL34 4.1 9.6 1.0
CA C:TYR35 4.1 9.1 1.0
CB C:VAL34 4.2 9.2 1.0
CG B:ASN26 4.2 8.5 1.0
CD C:LYS33 4.2 8.1 1.0
OD1 B:ASN26 4.2 8.5 1.0
CA C:LYS33 4.3 11.1 1.0
CG B:LYS47A 4.4 2.2 1.0
CG C:TYR35 4.5 9.4 1.0
CG C:LYS33 4.5 8.8 1.0
CH2 C:TRP62 4.5 2.1 1.0
CA B:LYS47A 4.6 5.5 1.0
O B:LYS47A 4.6 8.8 1.0
ND1 C:HIS64 4.7 6.3 1.0
CD B:LYS47A 4.7 2.4 1.0
C C:TYR35 4.8 9.7 1.0
O C:TYR35 4.8 10.1 1.0
C B:LYS47A 4.8 6.6 1.0
CE2 C:TYR35 4.9 9.2 1.0
CG2 C:VAL34 4.9 8.1 1.0
CZ3 C:TRP62 5.0 3.0 1.0

Reference:

A.M.De Vos, M.H.Ultsch, R.F.Kelley, K.Padmanabhan, A.Tulinsky, M.L.Westbrook, A.A.Kossiakoff. Crystal Structure of the Kringle 2 Domain of Tissue Plasminogen Activator at 2.4-A Resolution. Biochemistry V. 31 270 1992.
ISSN: ISSN 0006-2960
PubMed: 1310033
DOI: 10.1021/BI00116A037
Page generated: Sat Dec 12 08:50:16 2020

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