Chlorine in PDB 1u0h: Structural Basis For the Inhibition of Mammalian Adenylyl Cyclase By Mant-Gtp

Enzymatic activity of Structural Basis For the Inhibition of Mammalian Adenylyl Cyclase By Mant-Gtp

All present enzymatic activity of Structural Basis For the Inhibition of Mammalian Adenylyl Cyclase By Mant-Gtp:
4.6.1.1;

Protein crystallography data

The structure of Structural Basis For the Inhibition of Mammalian Adenylyl Cyclase By Mant-Gtp, PDB code: 1u0h was solved by T.C.Mou, A.Gille, R.J.Seifert, S.R.Sprang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	15.00 / 2.90
*Space group*	P 2₁ 2₁ 2
*Cell size a, b, c (Å), α, β, γ (°)*	118.400, 133.000, 70.400, 90.00, 90.00, 90.00
*R / R_free (%)*	24.5 / 28

Other elements in 1u0h:

The structure of Structural Basis For the Inhibition of Mammalian Adenylyl Cyclase By Mant-Gtp also contains other interesting chemical elements:

Magnesium

(Mg)

3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structural Basis For the Inhibition of Mammalian Adenylyl Cyclase By Mant-Gtp (pdb code 1u0h). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structural Basis For the Inhibition of Mammalian Adenylyl Cyclase By Mant-Gtp, PDB code: 1u0h:

Chlorine binding site 1 out of 1 in 1u0h

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Chlorine Binding Sites List in 1u0h

Chlorine binding site 1 out of 1 in the Structural Basis For the Inhibition of Mammalian Adenylyl Cyclase By Mant-Gtp

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structural Basis For the Inhibition of Mammalian Adenylyl Cyclase By Mant-Gtp within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
C:Cl397 b:50.0 occ:1.00	CB	C:ALA249	3.5	43.8	1.0
	N	C:ALA249	3.5	38.0	1.0
	CB	C:ALA48	3.7	28.6	1.0
	CB	C:ALA269	3.9	30.6	1.0
	CB	C:SER51	3.9	35.4	1.0
	CA	C:ALA249	4.1	38.3	1.0
	O	C:ARG265	4.1	37.5	1.0
	CA	C:SER51	4.2	32.8	1.0
	N	C:ALA48	4.4	30.4	1.0
	O	C:HOH398	4.4	40.7	1.0
	O	C:GLY49	4.4	36.9	1.0
	C	C:VAL248	4.4	37.9	1.0
	CA	C:VAL248	4.4	35.9	1.0
	CA	C:ALA48	4.5	31.0	1.0
	O	C:VAL247	4.7	36.0	1.0
	C	C:ALA48	4.7	33.1	1.0
	N	C:SER51	4.8	33.2	1.0
	CA	C:ALA269	4.9	31.3	1.0

Reference:

T.C.Mou, A.Gille, D.A.Fancy, R.Seifert, S.R.Sprang. Structural Basis For the Inhibition of Mammalian Membrane Adenylyl Cyclase By 2 '(3')-O-(N-Methylanthraniloyl)-Guanosine 5 '-Triphosphate. J.Biol.Chem. V. 280 7253 2005.
ISSN: ISSN 0021-9258
PubMed: 15591060
DOI: 10.1074/JBC.M409076200

Page generated: Sat Jul 20 02:37:39 2024

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