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Chlorine in PDB 1uv5: Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime

Enzymatic activity of Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime

All present enzymatic activity of Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime:
2.7.1.37;

Protein crystallography data

The structure of Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime, PDB code: 1uv5 was solved by R.Dajani, L.H.Pearl, S.M.Roe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.46 / 2.80
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 98.333, 98.333, 198.017, 90.00, 90.00, 90.00
R / Rfree (%) 19.3 / 22.6

Other elements in 1uv5:

The structure of Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime also contains other interesting chemical elements:

Cobalt (Co) 1 atom
Bromine (Br) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime (pdb code 1uv5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime, PDB code: 1uv5:

Chlorine binding site 1 out of 1 in 1uv5

Go back to Chlorine Binding Sites List in 1uv5
Chlorine binding site 1 out of 1 in the Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1385

b:87.6
occ:1.00
 N A:PHE360 3.4 75.1 1.0
N A:LEU359 3.6 74.6 1.0
N A:ASN361 3.9 74.0 1.0
CD1 A:PHE360 3.9 74.1 1.0
CB A:PHE360 4.0 73.7 1.0
CA A:ALA358 4.0 75.0 1.0
CA A:PHE360 4.1 74.2 1.0
OD1 A:ASN361 4.2 78.5 1.0
CG A:PHE360 4.2 74.5 1.0
C A:ALA358 4.3 75.5 1.0
C A:PHE360 4.3 74.1 1.0
C A:LEU359 4.5 75.1 1.0
CA A:LEU359 4.6 73.0 1.0
CB A:ALA358 4.6 73.5 1.0
CG A:ASN361 4.7 73.8 1.0
CB A:ASN361 4.7 73.6 1.0
O A:PRO357 4.7 77.3 1.0
CE1 A:PHE360 4.8 75.5 1.0
CA A:ASN361 4.8 73.8 1.0

Reference:

L.Meijer, A.-L.Skaltsounis, P.Magiatis, P.Polychronopoulous, M.Knockaert, M.Leost, X.P.Ryan, C.A.Vonica, A.Brivanlou, R.Dajani, C.Crovace, C.Tarricone, A.Musacchio, S.M.Roe, L.H.Pearl, P.Greengard. Gsk-3-Selective Inhibitors Derived From Tyrian Purple Indurubins Chem.Biol. V. 10 1255 2003.
ISSN: ISSN 1074-5521
PubMed: 14700633
DOI: 10.1016/J.CHEMBIOL.2003.11.010
Page generated: Sat Dec 12 08:51:07 2020

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