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Atomistry » Chlorine » PDB 1utr-1v8c » 1v3x | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 1utr-1v8c » 1v3x » |
Chlorine in PDB 1v3x: Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)PiperazineEnzymatic activity of Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine
All present enzymatic activity of Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine:
3.4.21.6; Protein crystallography data
The structure of Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine, PDB code: 1v3x
was solved by
M.Suzuki,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 1v3x:
The structure of Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine
(pdb code 1v3x). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine, PDB code: 1v3x: Chlorine binding site 1 out of 1 in 1v3xGo back to Chlorine Binding Sites List in 1v3x
Chlorine binding site 1 out
of 1 in the Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine
Mono view Stereo pair view
Reference:
N.Haginoya,
S.Kobayashi,
S.Komoriya,
T.Yoshino,
M.Suzuki,
T.Shimada,
K.Watanabe,
Y.Hirokawa,
T.Furugori,
T.Nagahara.
Synthesis and Conformational Analysis of A Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridine As S4 Binding Element J.Med.Chem. V. 47 5167 2004.
Page generated: Sat Dec 12 08:51:27 2020
ISSN: ISSN 0022-2623 PubMed: 15456260 DOI: 10.1021/JM049884D |
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