Chlorine in PDB 1wm0: Ppargamma in Complex with A 2-Baba Compound

The structure of Ppargamma in Complex with A 2-Baba Compound, PDB code: 1wm0 was solved by T.Ostberg, S.Svensson, G.Selen, J.Uppenberg, M.Thor, M.Sundbom, M.Sydow-Backman, A.L.Gustavsson, L.Jendeberg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	14.70 / 2.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	49.166, 66.324, 122.671, 90.00, 90.00, 90.00
R / Rfree (%)	19.1 / 29.5

The binding sites of Chlorine atom in the Ppargamma in Complex with A 2-Baba Compound (pdb code 1wm0). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Ppargamma in Complex with A 2-Baba Compound, PDB code: 1wm0:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Ppargamma in Complex with A 2-Baba Compound


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Ppargamma in Complex with A 2-Baba Compound within 5.0Å range: probe atom residue distance (Å) B Occ X:Cl1 b:46.5 occ:1.00 CL20 X:PLB1 0.0 46.5 1.0 C16 X:PLB1 1.8 49.7 1.0 C15 X:PLB1 2.6 52.6 1.0 C17 X:PLB1 2.8 48.3 1.0 CE X:MET329 3.6 51.9 1.0 C14 X:PLB1 3.9 54.0 1.0 NH1 X:ARG288 4.0 53.2 1.0 CB X:ALA292 4.0 32.9 1.0 C18 X:PLB1 4.1 48.5 1.0 CD X:ARG288 4.2 47.5 1.0 CG2 X:ILE326 4.4 30.0 1.0 O X:ILE326 4.4 32.4 1.0 C13 X:PLB1 4.5 51.6 1.0 CG X:LEU330 4.6 30.7 1.0 CB X:MET329 4.6 37.9 1.0 CG1 X:ILE326 4.8 33.1 1.0 CA X:ILE326 4.9 31.5 1.0 N X:LEU330 4.9 32.9 1.0 CZ X:ARG288 4.9 58.0 1.0 CB X:ILE326 4.9 32.0 1.0 NE X:ARG288 5.0 53.1 1.0

Chlorine binding site 2 out of 2 in the Ppargamma in Complex with A 2-Baba Compound


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Ppargamma in Complex with A 2-Baba Compound within 5.0Å range: probe atom residue distance (Å) B Occ X:Cl1 b:52.4 occ:1.00 CL19 X:PLB1 0.0 52.4 1.0 C14 X:PLB1 1.8 54.0 1.0 C15 X:PLB1 2.7 52.6 1.0 C13 X:PLB1 2.8 51.6 1.0 C11 X:PLB1 3.1 52.3 1.0 N10 X:PLB1 3.2 52.9 1.0 O X:LEU340 3.3 38.4 1.0 O9 X:PLB1 3.7 54.9 1.0 CD1 X:LEU333 3.8 37.9 1.0 O12 X:PLB1 3.9 52.4 1.0 C16 X:PLB1 4.0 49.7 1.0 C18 X:PLB1 4.1 48.5 1.0 CA X:ILE341 4.2 40.4 1.0 CG2 X:ILE341 4.2 39.6 1.0 C2 X:PLB1 4.3 52.1 1.0 CD2 X:LEU330 4.3 32.7 1.0 C X:LEU340 4.4 39.2 1.0 C17 X:PLB1 4.5 48.3 1.0 CG X:ARG288 4.6 41.0 1.0 CB X:ILE341 4.6 40.5 1.0 CD X:ARG288 4.6 47.5 1.0 CG1 X:VAL339 4.7 38.8 1.0 C7 X:PLB1 4.7 55.1 1.0 N X:ILE341 4.8 40.4 1.0 C1 X:PLB1 5.0 52.7 1.0

T.Ostberg, S.Svensson, G.Selen, J.Uppenberg, M.Thor, M.Sundbom, M.Sydow-Backman, A.L.Gustavsson, L.Jendeberg. A New Class of Peroxisome Proliferator-Activated Receptor Agonists with A Novel Binding Epitope Shows Antidiabetic Effects J.Biol.Chem. V. 279 41124 2004.
ISSN: ISSN 0021-9258
PubMed: 15258145
DOI: 10.1074/JBC.M401552200