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Chlorine in PDB 1xcw: Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts

Enzymatic activity of Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts

All present enzymatic activity of Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts:
3.2.1.1;

Protein crystallography data

The structure of Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts, PDB code: 1xcw was solved by C.Li, A.Begum, S.Numao, K.H.Park, S.G.Withers, G.D.Brayer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 52.900, 69.000, 131.900, 90.00, 90.00, 90.00
R / Rfree (%) 17.4 / 21.5

Other elements in 1xcw:

The structure of Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts also contains other interesting chemical elements:

Calcium (Ca) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts (pdb code 1xcw). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts, PDB code: 1xcw:

Chlorine binding site 1 out of 1 in 1xcw

Go back to Chlorine Binding Sites List in 1xcw
Chlorine binding site 1 out of 1 in the Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl498

b:13.3
occ:1.00
 NH2 A:ARG337 3.1 11.6 1.0
O A:HOH511 3.2 9.2 1.0
NE A:ARG195 3.2 9.5 1.0
NH1 A:ARG337 3.3 13.1 1.0
NH2 A:ARG195 3.4 11.8 1.0
ND2 A:ASN298 3.4 13.2 1.0
CZ A:ARG337 3.7 15.7 1.0
CZ A:ARG195 3.8 9.3 1.0
CG2 A:THR254 3.9 9.4 1.0
CZ A:PHE256 4.1 9.0 1.0
CG A:GLU233 4.2 11.8 1.0
CD A:ARG195 4.3 7.4 1.0
CB A:ASN298 4.4 10.8 1.0
CG A:ASN298 4.4 13.4 1.0
CB A:GLU233 4.7 11.0 1.0
CE1 A:PHE256 4.7 11.0 1.0
CZ A:PHE295 4.8 12.4 1.0
O A:HOH518 4.8 14.3 1.0
CE1 A:HIS299 4.9 16.1 1.0
CB A:THR254 4.9 11.5 1.0
CE1 A:PHE295 4.9 13.6 1.0
CG A:ARG195 4.9 9.2 1.0
CD A:GLU233 5.0 11.7 1.0
O A:HOH603 5.0 16.4 1.0
NE A:ARG337 5.0 14.6 1.0

Reference:

C.Li, A.Begum, S.Numao, K.H.Park, S.G.Withers, G.D.Brayer. Acarbose Rearrangement Mechanism Implied By the Kinetic and Structural Analysis of Human Pancreatic Alpha-Amylase in Complex with Analogues and Their Elongated Counterparts Biochemistry V. 44 3347 2005.
ISSN: ISSN 0006-2960
PubMed: 15736945
DOI: 10.1021/BI048334E
Page generated: Sat Jul 20 03:53:57 2024

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