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Atomistry » Chlorine » PDB 1wvu-1xkk » 1xkk | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 1wvu-1xkk » 1xkk » |
Chlorine in PDB 1xkk: Egfr Kinase Domain Complexed with A Quinazoline Inhibitor- GW572016Enzymatic activity of Egfr Kinase Domain Complexed with A Quinazoline Inhibitor- GW572016
All present enzymatic activity of Egfr Kinase Domain Complexed with A Quinazoline Inhibitor- GW572016:
2.7.1.112; Protein crystallography data
The structure of Egfr Kinase Domain Complexed with A Quinazoline Inhibitor- GW572016, PDB code: 1xkk
was solved by
E.R.Wood,
A.T.Truesdale,
O.B.Mcdonald,
D.Yuan,
A.Hassell,
S.H.Dickerson,
B.Ellis,
C.Pennisi,
E.Horne,
K.Lackey,
K.J.Alligood,
D.W.Rusnak,
T.M.Gilmer,
L.M.Shewchuk,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 1xkk:
The structure of Egfr Kinase Domain Complexed with A Quinazoline Inhibitor- GW572016 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Egfr Kinase Domain Complexed with A Quinazoline Inhibitor- GW572016
(pdb code 1xkk). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Egfr Kinase Domain Complexed with A Quinazoline Inhibitor- GW572016, PDB code: 1xkk: Chlorine binding site 1 out of 1 in 1xkkGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Egfr Kinase Domain Complexed with A Quinazoline Inhibitor- GW572016
![]() Mono view ![]() Stereo pair view
Reference:
E.R.Wood,
A.T.Truesdale,
O.B.Mcdonald,
D.Yuan,
A.Hassell,
S.H.Dickerson,
B.Ellis,
C.Pennisi,
E.Horne,
K.Lackey,
K.J.Alligood,
D.W.Rusnak,
T.M.Gilmer,
L.Shewchuk.
A Unique Structure For Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib): Relationships Among Protein Conformation, Inhibitor Off-Rate, and Receptor Activity in Tumor Cells. Cancer Res. V. 64 6652 2004.
Page generated: Thu Jul 10 20:26:39 2025
ISSN: ISSN 0008-5472 PubMed: 15374980 DOI: 10.1158/0008-5472.CAN-04-1168 |
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