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Chlorine in PDB 1xnz: Crystal Structure of Mn(II) Form of E. Coli. Methionine Aminopeptidase in Complex with 5-(2-Chlorophenyl)Furan-2- Carboxylic Acid

Enzymatic activity of Crystal Structure of Mn(II) Form of E. Coli. Methionine Aminopeptidase in Complex with 5-(2-Chlorophenyl)Furan-2- Carboxylic Acid

All present enzymatic activity of Crystal Structure of Mn(II) Form of E. Coli. Methionine Aminopeptidase in Complex with 5-(2-Chlorophenyl)Furan-2- Carboxylic Acid:
3.4.11.18;

Protein crystallography data

The structure of Crystal Structure of Mn(II) Form of E. Coli. Methionine Aminopeptidase in Complex with 5-(2-Chlorophenyl)Furan-2- Carboxylic Acid, PDB code: 1xnz was solved by Q.-Z.Ye, S.-X.Xie, M.Huang, W.-J.Huang, J.-P.Lu, Z.-Q.Ma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.52
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 37.600, 60.300, 49.700, 90.00, 104.80, 90.00
R / Rfree (%) 21.9 / 25

Other elements in 1xnz:

The structure of Crystal Structure of Mn(II) Form of E. Coli. Methionine Aminopeptidase in Complex with 5-(2-Chlorophenyl)Furan-2- Carboxylic Acid also contains other interesting chemical elements:

Manganese (Mn) 2 atoms
Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Mn(II) Form of E. Coli. Methionine Aminopeptidase in Complex with 5-(2-Chlorophenyl)Furan-2- Carboxylic Acid (pdb code 1xnz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Mn(II) Form of E. Coli. Methionine Aminopeptidase in Complex with 5-(2-Chlorophenyl)Furan-2- Carboxylic Acid, PDB code: 1xnz:

Chlorine binding site 1 out of 1 in 1xnz

Go back to Chlorine Binding Sites List in 1xnz
Chlorine binding site 1 out of 1 in the Crystal Structure of Mn(II) Form of E. Coli. Methionine Aminopeptidase in Complex with 5-(2-Chlorophenyl)Furan-2- Carboxylic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Mn(II) Form of E. Coli. Methionine Aminopeptidase in Complex with 5-(2-Chlorophenyl)Furan-2- Carboxylic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl268

b:1.8
occ:1.00
 CL2 A:FCD268 0.0 1.8 1.0
C6 A:FCD268 1.7 12.2 1.0
C5 A:FCD268 2.7 13.8 1.0
C1 A:FCD268 2.7 12.6 1.0
CD A:FCD268 3.2 14.0 1.0
CG A:FCD268 3.2 13.2 1.0
CG A:TYR65 3.6 14.7 1.0
CB A:TYR65 3.7 13.1 1.0
CD1 A:TYR65 3.9 13.5 1.0
C4 A:FCD268 4.0 15.9 1.0
C2 A:FCD268 4.0 14.8 1.0
CD2 A:TYR62 4.1 19.5 1.0
CD2 A:TYR65 4.2 15.1 1.0
SG A:CYS70 4.2 12.5 1.0
OA A:FCD268 4.3 13.4 1.0
CB A:FCD268 4.4 13.3 1.0
O A:TYR62 4.4 13.8 1.0
CB A:CYS59 4.5 16.2 1.0
O A:CYS59 4.5 13.9 1.0
SG A:CYS59 4.5 21.7 1.0
C3 A:FCD268 4.5 15.2 1.0
CB A:TYR62 4.6 15.7 1.0
CZ3 A:TRP221 4.6 15.2 1.0
CE1 A:TYR65 4.7 14.3 1.0
CA A:CYS59 4.7 14.4 1.0
CG A:TYR62 4.9 16.6 1.0
CE2 A:TYR65 4.9 14.8 1.0
CH2 A:TRP221 5.0 15.3 1.0
CE2 A:PHE177 5.0 14.4 1.0
CA A:FCD268 5.0 12.6 1.0
CE2 A:TYR62 5.0 20.5 1.0

Reference:

Q.-Z.Ye, S.-X.Xie, M.Huang, W.-J.Huang, J.-P.Lu, Z.-Q.Ma. Metalloform-Selective Inhibitors of Escherichia Coli Methionine Aminopeptidase and X-Ray Structure of A Mn(II)-Form Enzyme Complexed with An Inhibitor. J.Am.Chem.Soc. V. 126 13940 2004.
ISSN: ISSN 0002-7863
PubMed: 15506752
DOI: 10.1021/JA045864P
Page generated: Sat Jul 20 04:01:29 2024

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