Chlorine in PDB 1xw7: Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama

The structure of Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama, PDB code: 1xw7 was solved by Z.L.Wan, K.Huang, B.Xu, Y.C.Chu, S.Q.Hu, P.G.Katsoyannis, M.A.Weiss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.10 / 2.30
Space group	P 21 3
Cell size a, b, c (Å), α, β, γ (°)	70.852, 70.852, 70.852, 90.00, 90.00, 90.00
R / Rfree (%)	20.5 / 26.9

The structure of Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama (pdb code 1xw7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama, PDB code: 1xw7:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl102 b:1.4 occ:0.33 ZN B:ZN101 2.4 4.1 0.3 NE2 B:HIS10 3.7 35.1 1.0 CB B:LEU6 3.8 30.3 1.0 CD1 B:LEU6 4.0 27.5 1.0 CD2 B:HIS10 4.1 32.7 1.0 CG B:LEU6 4.5 31.3 1.0 C B:LEU6 4.7 30.9 1.0 O B:LEU6 4.7 31.2 1.0 CA B:LEU6 4.8 30.2 1.0 CE1 B:HIS10 4.8 37.2 1.0

Chlorine binding site 2 out of 2 in the Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl202 b:12.5 occ:0.33 ZN D:ZN201 2.3 7.7 0.3 NE2 D:HIS10 3.2 33.5 1.0 CB D:LEU6 3.8 41.7 1.0 O D:HOH203 3.9 37.0 0.3 CD2 D:HIS10 3.9 34.0 1.0 CD1 D:LEU6 4.0 42.4 1.0 CE1 D:HIS10 4.1 32.3 1.0 CG D:LEU6 4.5 43.8 1.0 O D:LEU6 4.6 41.0 1.0 CA D:LEU6 4.8 43.0 1.0 C D:LEU6 4.8 42.0 1.0 CD2 D:LEU6 5.0 42.8 1.0

Z.L.Wan, K.Huang, B.Xu, S.Q.Hu, S.Wang, Y.C.Chu, P.G.Katsoyannis, M.A.Weiss. Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama Biochemistry V. 44 5000 2005.
ISSN: ISSN 0006-2960
PubMed: 15794638
DOI: 10.1021/BI047585K