Chlorine in PDB 1yvz: Hepatitis C Virus Rna Polymerase Genotype 2A in Complex with Non- Nucleoside Analogue Inhibitor

The structure of Hepatitis C Virus Rna Polymerase Genotype 2A in Complex with Non- Nucleoside Analogue Inhibitor, PDB code: 1yvz was solved by B.K.Biswal, M.M.Cherney, M.Wang, L.Chan, C.G.Yannopoulos, D.Bilimoria, O.Nicolas, J.Bedard, M.N.G.James, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.29 / 2.20
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	60.579, 214.624, 124.041, 90.00, 90.00, 90.00
R / Rfree (%)	21.5 / 23.4

The binding sites of Chlorine atom in the Hepatitis C Virus Rna Polymerase Genotype 2A in Complex with Non- Nucleoside Analogue Inhibitor (pdb code 1yvz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Hepatitis C Virus Rna Polymerase Genotype 2A in Complex with Non- Nucleoside Analogue Inhibitor, PDB code: 1yvz:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Hepatitis C Virus Rna Polymerase Genotype 2A in Complex with Non- Nucleoside Analogue Inhibitor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Hepatitis C Virus Rna Polymerase Genotype 2A in Complex with Non- Nucleoside Analogue Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl578 b:1.4 occ:1.00 CL13 A:JPC578 0.0 1.4 1.0 C10 A:JPC578 1.7 21.4 1.0 C9 A:JPC578 2.7 23.2 1.0 C11 A:JPC578 2.7 21.1 1.0 NE A:ARG422 3.3 29.6 1.0 CZ A:ARG422 3.4 27.7 1.0 NH1 A:ARG422 3.5 29.6 1.0 CB A:ARG422 3.5 23.1 1.0 CG A:TRP528 3.8 22.9 1.0 CG A:MET423 3.9 22.0 1.0 CD2 A:TRP528 4.0 21.9 1.0 CD A:ARG422 4.0 25.8 1.0 C8 A:JPC578 4.0 24.9 1.0 C12 A:JPC578 4.1 24.1 1.0 CG1 A:ILE419 4.1 21.1 1.0 CG A:ARG422 4.1 24.1 1.0 CB A:TRP528 4.1 24.1 1.0 CD1 A:TRP528 4.1 20.8 1.0 NH2 A:ARG422 4.2 27.6 1.0 OH A:TYR477 4.2 26.5 1.0 CE2 A:TYR477 4.2 24.9 1.0 CE2 A:TRP528 4.4 21.5 1.0 CA A:ILE419 4.4 19.7 1.0 CE3 A:TRP528 4.5 23.5 1.0 NE1 A:TRP528 4.5 22.0 1.0 C7 A:JPC578 4.6 26.0 1.0 O A:ILE419 4.6 20.5 1.0 CZ A:TYR477 4.7 24.0 1.0 SD A:MET423 4.7 23.5 1.0 CB A:ILE419 4.7 19.6 1.0 N A:MET423 4.8 21.4 1.0 CD1 A:ILE419 4.8 20.4 1.0 CA A:ARG422 4.8 22.8 1.0 C A:ARG422 4.9 22.3 1.0 O A:LEU474 4.9 25.8 1.0

Chlorine binding site 2 out of 2 in the Hepatitis C Virus Rna Polymerase Genotype 2A in Complex with Non- Nucleoside Analogue Inhibitor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Hepatitis C Virus Rna Polymerase Genotype 2A in Complex with Non- Nucleoside Analogue Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl578 b:10.5 occ:1.00 CL14 A:JPC578 0.0 10.5 1.0 C12 A:JPC578 1.8 24.1 1.0 C11 A:JPC578 2.8 21.1 1.0 C7 A:JPC578 2.8 26.0 1.0 C5 A:JPC578 3.3 29.1 1.0 C19 A:JPC578 3.5 32.1 1.0 CD A:LYS501 3.7 36.9 1.0 N1 A:JPC578 3.7 32.3 1.0 C15 A:JPC578 3.8 33.6 1.0 CE A:LYS501 3.8 39.1 1.0 CE3 A:TRP528 3.9 23.5 1.0 O6 A:JPC578 3.9 30.3 1.0 CE A:MET423 4.0 25.3 1.0 C10 A:JPC578 4.1 21.4 1.0 NZ A:LYS501 4.1 43.2 1.0 C8 A:JPC578 4.2 24.9 1.0 CZ3 A:TRP528 4.2 19.8 1.0 CG A:LYS501 4.2 34.4 1.0 SD A:MET423 4.3 23.5 1.0 O A:TRP528 4.3 26.0 1.0 C18 A:JPC578 4.4 32.2 1.0 O A:HOH749 4.5 40.0 1.0 C28 A:JPC578 4.6 33.1 1.0 C9 A:JPC578 4.7 23.2 1.0 C3 A:JPC578 4.7 35.9 1.0 C16 A:JPC578 4.8 32.5 1.0 C2 A:JPC578 4.8 33.4 1.0 CB A:LYS501 4.9 29.6 1.0 O A:HOH748 5.0 40.5 1.0 O A:HOH835 5.0 51.8 1.0

B.K.Biswal, M.M.Cherney, M.Wang, L.Chan, C.G.Yannopoulos, D.Bilimoria, O.Nicolas, J.Bedard, M.N.G.James. Crystal Structures of the Rna Dependent Rna Polymerase Genotype 2A of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition By Non-Nucleoside Inhibitors. J.Biol.Chem. V. 280 18202 2005.
ISSN: ISSN 0021-9258
PubMed: 15746101
DOI: 10.1074/JBC.M413410200