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Chlorine in PDB 1z4u: Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585

Enzymatic activity of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585

All present enzymatic activity of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585:
2.7.7.48;

Protein crystallography data

The structure of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585, PDB code: 1z4u was solved by J.A.Pfefferkorn, M.Greene, R.Nugent, R.J.Gross, M.A.Mitchell, B.C.Finzel, M.S.Harris, P.A.Wells, J.A.Shelly, R.Anstadt, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.80
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 91.344, 91.344, 189.111, 90.00, 90.00, 120.00
R / Rfree (%) 20.8 / 26.5

Other elements in 1z4u:

The structure of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585 also contains other interesting chemical elements:

Bromine (Br) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585 (pdb code 1z4u). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585, PDB code: 1z4u:

Chlorine binding site 1 out of 1 in 1z4u

Go back to Chlorine Binding Sites List in 1z4u
Chlorine binding site 1 out of 1 in the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl701

b:58.2
occ:0.50
N A:GLY480 3.2 58.2 1.0
CA A:GLY480 3.8 57.0 1.0
CB A:SER478 3.9 72.2 1.0
CD A:PRO479 4.0 65.9 1.0
N A:PRO479 4.1 65.7 1.0
C A:SER478 4.3 67.8 1.0
C A:PRO479 4.3 60.4 1.0
CB A:PRO479 4.4 62.9 1.0
CA A:PRO479 4.5 62.7 1.0
CA A:SER478 4.5 71.2 1.0
OG A:SER478 4.6 75.9 1.0
CG A:PRO479 4.7 64.3 1.0
O3 A:PO4702 4.8 96.8 1.0
O A:SER478 4.8 67.5 1.0

Reference:

J.A.Pfefferkorn, R.Nugent, R.J.Gross, M.Greene, M.A.Mitchell, M.T.Reding, L.A.Funk, R.Anderson, P.A.Wells, J.A.Shelly, R.Anstadt, B.C.Finzel, M.S.Harris, R.E.Kilkuskie, L.A.Kopta, F.J.Schwende. Inhibitors of Hcv NS5B Polymerase. Part 2: Evaluation of the Northern Region of (2Z)-2-Benzoylamino-3-(4-Phenoxy-Phenyl)-Acrylic Acid Bioorg.Med.Chem.Lett. V. 15 2812 2005.
ISSN: ISSN 0960-894X
PubMed: 15911260
DOI: 10.1016/J.BMCL.2005.03.106
Page generated: Sat Jul 20 04:33:49 2024

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