Chlorine in PDB 1zd6: Crystal Structure of Human Transthyretin with Bound Chloride

The structure of Crystal Structure of Human Transthyretin with Bound Chloride, PDB code: 1zd6 was solved by A.Hornberg, U.W.Hultdin, A.Olofsson, A.E.Sauer-Eriksson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.69 / 1.90
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	42.659, 85.587, 63.490, 90.00, 90.00, 90.00
R / Rfree (%)	20 / 22.1

The binding sites of Chlorine atom in the Crystal Structure of Human Transthyretin with Bound Chloride (pdb code 1zd6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Crystal Structure of Human Transthyretin with Bound Chloride, PDB code: 1zd6:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in the Crystal Structure of Human Transthyretin with Bound Chloride


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Transthyretin with Bound Chloride within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:28.2 occ:0.67 OG A:SER117 2.9 12.7 1.0 OG1 A:THR119 3.0 12.9 1.0 O A:HOH321 3.1 37.0 1.0 O A:SER117 3.4 9.9 1.0 C A:SER117 3.4 10.6 1.0 N A:THR119 3.5 11.2 1.0 CA A:THR118 3.5 11.0 1.0 N A:THR118 3.6 10.6 1.0 C A:THR118 3.6 11.3 1.0 CB A:THR119 3.8 11.2 1.0 CB A:SER117 3.8 11.0 1.0 O A:ALA108 3.8 12.8 1.0 N A:LEU110 4.0 11.5 1.0 C A:ALA108 4.2 12.3 1.0 CA A:ALA109 4.2 11.6 1.0 CB A:LEU110 4.2 11.8 1.0 CA A:SER117 4.3 10.6 1.0 CA A:THR119 4.3 11.3 1.0 O A:THR118 4.3 12.0 1.0 C A:ALA109 4.3 11.6 1.0 N A:ALA109 4.4 11.9 1.0 O A:HOH316 4.5 16.1 0.5 CB A:ALA108 4.6 12.2 1.0 CA A:LEU110 4.8 11.4 1.0 OG B:SER115 4.9 11.4 1.0 CB A:THR118 5.0 11.1 1.0

Chlorine binding site 2 out of 6 in the Crystal Structure of Human Transthyretin with Bound Chloride


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Transthyretin with Bound Chloride within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl302 b:42.0 occ:0.37 NZ A:LYS15 3.2 24.0 1.0 CE A:LYS15 3.7 20.8 1.0 CD2 A:LEU17 4.0 11.8 1.0 CD1 A:LEU17 4.4 12.3 1.0 CG A:LEU17 4.8 10.4 1.0

Chlorine binding site 3 out of 6 in the Crystal Structure of Human Transthyretin with Bound Chloride


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human Transthyretin with Bound Chloride within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl306 b:29.7 occ:0.65 NZ B:LYS35 2.9 29.9 1.0 O A:HOH334 3.3 36.1 1.0 NE2 A:HIS90 3.4 18.6 0.5 CE1 A:HIS90 3.6 16.1 0.5 CE B:LYS35 3.8 29.8 1.0 CZ2 B:TRP41 3.9 24.3 1.0 CG1 B:VAL94 4.0 13.9 1.0 CD B:LYS35 4.0 28.9 1.0 CG2 B:ILE68 4.1 14.4 1.0 CD2 A:HIS90 4.2 17.7 0.5 CH2 B:TRP41 4.2 23.4 1.0 CE1 A:HIS90 4.4 18.9 0.5 ND1 A:HIS90 4.4 15.4 0.5 NE2 A:HIS90 4.5 16.9 0.5 CD1 B:ILE68 4.6 16.0 1.0 CB A:GLU89 4.6 13.2 1.0 CG A:GLU89 4.7 13.7 1.0

Chlorine binding site 4 out of 6 in the Crystal Structure of Human Transthyretin with Bound Chloride


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human Transthyretin with Bound Chloride within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl303 b:30.3 occ:0.55 O B:HOH327 2.8 41.5 1.0 NE2 B:HIS90 3.3 20.4 0.5 CE A:LYS35 3.8 23.1 1.0 CE1 B:HIS90 4.0 17.6 0.5 CZ2 A:TRP41 4.0 17.6 1.0 NZ A:LYS35 4.1 24.9 1.0 CG1 A:VAL94 4.1 10.0 1.0 CG2 A:ILE68 4.1 9.3 1.0 CD2 B:HIS90 4.2 19.4 0.5 CD A:LYS35 4.2 21.1 1.0 CE1 B:HIS90 4.3 20.0 0.5 CH2 A:TRP41 4.4 16.8 1.0 ND1 B:HIS90 4.5 16.8 0.5 CB B:GLU89 4.5 13.8 1.0 CG B:GLU89 4.6 13.9 1.0 CD1 A:ILE68 4.6 12.1 1.0 OE1 B:GLU89 4.8 17.0 1.0

Chlorine binding site 5 out of 6 in the Crystal Structure of Human Transthyretin with Bound Chloride


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Human Transthyretin with Bound Chloride within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl304 b:28.0 occ:0.69 OG1 B:THR119 2.8 14.4 1.0 OG B:SER117 2.9 13.4 1.0 N B:THR119 3.3 12.4 1.0 C B:THR118 3.5 12.0 1.0 CA B:THR118 3.5 11.7 1.0 O B:SER117 3.5 11.3 1.0 CB B:THR119 3.6 13.2 1.0 C B:SER117 3.6 11.6 1.0 N B:THR118 3.6 11.2 1.0 O B:ALA108 3.7 13.7 1.0 CB B:SER117 4.0 12.0 1.0 CA B:THR119 4.0 13.0 1.0 C B:ALA108 4.2 12.8 1.0 O B:THR118 4.2 12.0 1.0 N B:LEU110 4.2 11.2 1.0 CA B:ALA109 4.3 12.1 1.0 CA B:SER117 4.4 11.6 1.0 CB B:LEU110 4.4 11.3 1.0 N B:ALA109 4.5 12.3 1.0 C B:ALA109 4.5 11.6 1.0 CB B:ALA108 4.6 13.2 1.0 OG A:SER115 4.7 13.1 1.0 O B:HOH314 4.7 18.4 0.5 CG2 B:THR119 4.9 12.6 1.0 CB B:THR118 4.9 10.9 1.0

Chlorine binding site 6 out of 6 in the Crystal Structure of Human Transthyretin with Bound Chloride


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of Human Transthyretin with Bound Chloride within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl305 b:36.6 occ:0.41 NZ B:LYS15 3.3 25.4 1.0 CE B:LYS15 3.3 23.0 1.0 CD2 B:LEU17 4.2 13.4 1.0 CD1 B:LEU17 4.4 13.9 1.0 CD B:LYS15 4.8 20.4 1.0 CG B:LEU17 4.9 12.8 1.0

A.Hornberg, U.W.Hultdin, A.Olofsson, A.E.Sauer-Eriksson. The Effect of Iodide and Chloride on Transthyretin Structure and Stability Biochemistry V. 44 9290 2005.
ISSN: ISSN 0006-2960
PubMed: 15981995
DOI: 10.1021/BI050249Z