Chlorine in PDB 1zhj: Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose

All present enzymatic activity of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose:
2.4.1.40;

The structure of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose, PDB code: 1zhj was solved by J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.59
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	52.700, 149.500, 79.600, 90.00, 90.00, 90.00
R / Rfree (%)	19.8 / 22

The structure of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose also contains other interesting chemical elements:

Mercury

(Hg)

5 atoms

The binding sites of Chlorine atom in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose (pdb code 1zhj). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose, PDB code: 1zhj:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl403 b:34.4 occ:1.00 OG1 A:THR119 2.8 22.5 1.0 CL A:CL408 2.8 34.4 1.0 CE1 A:PHE121 3.3 33.5 1.0 CD1 A:PHE121 3.4 32.5 1.0 O A:THR119 3.5 18.5 1.0 CB A:CYS209 3.7 16.5 1.0 CB A:THR119 3.7 18.2 1.0 HG A:HG404 3.7 25.8 0.7 C A:THR119 3.8 17.0 1.0 CA A:CYS209 4.0 16.0 1.0 N A:VAL120 4.2 18.0 1.0 O A:HOH556 4.3 26.8 1.0 O A:VAL210 4.3 17.7 1.0 N A:VAL210 4.4 15.9 1.0 CA A:VAL120 4.4 18.5 1.0 CA A:THR119 4.4 16.9 1.0 C A:CYS209 4.4 14.8 1.0 CZ A:PHE121 4.6 34.5 1.0 SG A:CYS209 4.6 23.8 1.0 C A:VAL120 4.8 20.7 1.0 CG A:PHE121 4.8 30.4 1.0 N A:PHE121 4.8 21.2 1.0 CG2 A:THR119 4.9 19.3 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human N-Acetylgalactosaminyltransferase (Gta) Complexed with Galactose within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl408 b:34.4 occ:1.00 O A:HOH601 2.6 30.4 1.0 CL A:CL403 2.8 34.4 1.0 CB A:CYS209 3.5 16.5 1.0 C A:CYS209 3.7 14.8 1.0 N A:VAL210 3.8 15.9 1.0 O A:VAL210 3.8 17.7 1.0 O A:CYS209 3.9 15.0 1.0 CA A:CYS209 4.1 16.0 1.0 O A:HOH556 4.1 26.8 1.0 CE2 A:PHE270 4.1 20.6 1.0 C A:VAL210 4.1 17.3 1.0 CA A:VAL210 4.2 15.2 1.0 O A:GLY267 4.5 21.7 1.0 CZ A:PHE270 4.6 20.1 1.0 OD2 A:ASP211 4.7 26.4 1.0 N A:ASP211 4.9 18.9 1.0 CD2 A:PHE270 5.0 17.5 1.0

J.A.Letts, N.L.Rose, Y.R.Fang, C.H.Barry, S.N.Borisova, N.O.Seto, M.M.Palcic, S.V.Evans. Differential Recognition of the Type I and II H Antigen Acceptors By the Human Abo(H) Blood Group A and B Glycosyltransferases. J.Biol.Chem. V. 281 3625 2006.
ISSN: ISSN 0021-9258
PubMed: 16326711
DOI: 10.1074/JBC.M507620200