Chlorine in PDB 1zlt: Crystal Structure of CHK1 Complexed with A Hymenaldisine Analog

All present enzymatic activity of Crystal Structure of CHK1 Complexed with A Hymenaldisine Analog:
2.7.1.37;

The structure of Crystal Structure of CHK1 Complexed with A Hymenaldisine Analog, PDB code: 1zlt was solved by C.C.Lee, K.Ng, Y.Wan, N.Gray, G.Spraggon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.74
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	45.000, 65.643, 58.112, 90.00, 94.71, 90.00
R / Rfree (%)	22.7 / 26.5

The binding sites of Chlorine atom in the Crystal Structure of CHK1 Complexed with A Hymenaldisine Analog (pdb code 1zlt). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of CHK1 Complexed with A Hymenaldisine Analog, PDB code: 1zlt:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of CHK1 Complexed with A Hymenaldisine Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of CHK1 Complexed with A Hymenaldisine Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl400 b:28.5 occ:1.00 CLA A:HYM400 0.0 28.5 1.0 CAA A:HYM400 1.8 20.9 1.0 O A:LEU15 2.7 27.1 1.0 NAC A:HYM400 2.8 23.3 1.0 CAB A:HYM400 2.9 22.7 1.0 CLB A:HYM400 3.5 9.9 1.0 C A:LEU15 3.5 31.1 1.0 O A:HOH990 3.9 29.7 1.0 CAD A:HYM400 4.0 22.7 1.0 OE1 A:GLU91 4.0 28.3 1.0 CAE A:HYM400 4.0 19.5 1.0 CB A:LEU15 4.0 29.2 1.0 N A:GLY16 4.2 29.1 1.0 CA A:GLY16 4.2 30.6 1.0 CG A:GLU91 4.3 22.2 1.0 CA A:LEU15 4.3 31.3 1.0 CD A:GLU91 4.6 27.0 1.0 O A:HOH1014 4.6 18.2 1.0 O A:HOH980 4.6 40.7 1.0 O A:HOH1068 5.0 24.8 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of CHK1 Complexed with A Hymenaldisine Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of CHK1 Complexed with A Hymenaldisine Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl400 b:9.9 occ:1.00 CLB A:HYM400 0.0 9.9 1.0 CAB A:HYM400 1.8 22.7 1.0 NAP A:HYM400 2.7 23.7 1.0 CAA A:HYM400 2.8 20.9 1.0 CAE A:HYM400 2.9 19.5 1.0 CAL A:HYM400 3.3 23.4 1.0 O A:HOH1014 3.3 18.2 1.0 CAJ A:HYM400 3.4 23.1 1.0 CLA A:HYM400 3.5 28.5 1.0 CG2 A:VAL23 3.6 21.9 1.0 CAO A:HYM400 3.6 24.2 1.0 O A:GLU17 3.6 30.4 1.0 N A:GLU17 3.6 33.8 1.0 CB A:VAL23 3.8 21.6 1.0 CA A:GLY16 3.9 30.6 1.0 NAC A:HYM400 3.9 23.3 1.0 C A:GLY16 3.9 33.9 1.0 CAD A:HYM400 4.0 22.7 1.0 C A:GLU17 4.0 34.8 1.0 NAQ A:HYM400 4.1 22.6 1.0 CG1 A:VAL23 4.3 18.8 1.0 N A:GLY16 4.3 29.1 1.0 CAM A:HYM400 4.4 21.7 1.0 CA A:GLU17 4.4 35.2 1.0 NAN A:HYM400 4.5 25.4 1.0 O A:GLY16 4.6 32.7 1.0 N A:GLY18 4.6 35.4 1.0 O A:LEU15 4.6 27.1 1.0 C A:LEU15 4.7 31.1 1.0 CAI A:HYM400 4.8 20.1 1.0 OE1 A:GLU91 4.8 28.3 1.0 CA A:GLY18 5.0 34.4 1.0

C.C.Lee, K.Ng, Y.Wan, N.Gray, G.Spraggon. Crystal Structure of CHK1 Complexed with A Hymenaldisine Analog To Be Published.