Chlorine in PDB 1zni: Insulin

The structure of Insulin, PDB code: 1zni was solved by M.G.W.Turkenburg, J.L.Whittingham, G.G.Dodson, E.J.Dodson, B.Xiao, G.A.Bentley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 1.50
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	80.700, 80.700, 37.600, 90.00, 90.00, 120.00
R / Rfree (%)	17.8 / n/a

The structure of Insulin also contains other interesting chemical elements:

Zinc

(Zn)

3 atoms

The binding sites of Chlorine atom in the Insulin (pdb code 1zni). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Insulin, PDB code: 1zni:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Insulin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Insulin within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl33 b:21.3 occ:0.17 ZN B:ZN31 2.3 16.3 0.2 NE2 B:HIS10 3.6 14.9 0.5 CB B:LEU6 4.0 17.8 1.0 CD2 B:HIS10 4.0 13.9 0.5 CD1 B:LEU6 4.1 31.1 1.0 CG B:LEU6 4.6 27.1 1.0 CE1 B:HIS10 4.7 17.6 0.5 O B:LEU6 4.9 19.4 1.0 C B:LEU6 4.9 18.9 1.0 CD2 B:LEU6 5.0 33.5 1.0

Chlorine binding site 2 out of 3 in the Insulin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Insulin within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl34 b:21.1 occ:0.50 ZN B:ZN32 2.3 21.2 0.5 O A:HOH24 3.2 31.1 1.0 NE2 B:HIS10 3.3 25.4 0.5 O A:HOH31 3.4 42.6 1.0 CD2 B:HIS10 3.6 22.7 0.5 CL B:CL35 3.9 23.6 0.5 CD2 B:LEU11 3.9 25.5 1.0 CB B:ALA14 3.9 18.2 1.0 CD1 A:LEU16 4.0 27.8 1.0 O A:CYS11 4.4 29.9 1.0 CE1 B:HIS10 4.5 23.7 0.5 CD2 A:LEU16 4.5 27.9 1.0 CG A:LEU16 4.8 23.3 1.0 CG B:HIS10 4.9 14.2 0.5

Chlorine binding site 3 out of 3 in the Insulin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Insulin within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl35 b:23.6 occ:0.50 ZN B:ZN32 2.3 21.2 0.5 NE2 B:HIS10 3.3 25.4 0.5 CE1 B:HIS10 3.4 23.7 0.5 O A:HOH31 3.6 42.6 1.0 CL B:CL34 3.9 21.1 0.5 CD2 B:HIS10 4.7 22.7 0.5 ND1 B:HIS10 4.7 17.6 0.5 CB B:ALA14 4.7 18.2 1.0

G.Bentley, E.Dodson, G.Dodson, D.Hodgkin, D.Mercola. Structure of Insulin in 4-Zinc Insulin. Nature V. 261 166 1976.
ISSN: ISSN 0028-0836
PubMed: 1272390
DOI: 10.1038/261166A0