Chlorine in PDB 1zsv: Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase

The structure of Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase, PDB code: 1zsv was solved by A.P.Turnbull, C.Johansson, P.Savitsky, K.Guo, A.Edwards, C.Arrowsmith, M.Sundstrom, F.Von Delft, U.Oppermann, Structuralgenomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	62.30 / 2.30
Space group	P 43
Cell size a, b, c (Å), α, β, γ (°)	92.543, 92.543, 202.770, 90.00, 90.00, 90.00
R / Rfree (%)	19.5 / 24.9

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 22;

Binding sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase (pdb code 1zsv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 22 binding sites of Chlorine where determined in the Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase, PDB code: 1zsv:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 22 in the Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl407 b:28.6 occ:1.00 CE2 A:TYR193 2.8 75.7 1.0 CD2 A:TYR193 3.0 73.8 1.0 CZ A:TYR193 3.5 74.3 1.0 N A:ALA149 3.8 49.1 1.0 CG A:TYR193 3.8 64.6 1.0 O A:ALA172 3.9 40.7 1.0 OH A:TYR193 4.1 69.1 1.0 CG1 A:VAL218 4.1 42.5 1.0 C A:ALA172 4.2 40.0 1.0 N A:VAL173 4.2 44.4 1.0 CE1 A:TYR193 4.3 71.3 1.0 CA A:ALA149 4.3 45.7 1.0 CE1 A:PHE222 4.3 45.5 1.0 CD1 A:TYR193 4.4 70.6 1.0 C A:VAL173 4.5 44.3 1.0 CA A:VAL173 4.6 45.8 1.0 O A:VAL173 4.6 45.6 1.0 CB A:ASN148 4.6 43.5 1.0 CB A:ALA172 4.6 37.7 1.0 CD1 A:PHE222 4.7 50.1 1.0 CB A:TYR193 4.7 57.7 1.0 N A:GLY174 4.8 46.1 1.0 C A:ASN148 4.9 48.1 1.0 CZ A:PHE222 4.9 48.0 1.0 CB A:ALA149 4.9 45.8 1.0 CA A:ASN148 5.0 44.5 1.0 CG2 A:VAL218 5.0 50.2 1.0

Chlorine binding site 2 out of 22 in the Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl408 b:40.5 occ:1.00 O A:HOH447 3.0 34.4 1.0 NZ A:LYS324 3.4 42.4 1.0 N A:THR325 3.5 46.1 1.0 CG A:MET316 3.7 50.2 1.0 O A:VAL46 3.8 47.4 1.0 CD A:LYS324 3.8 41.6 1.0 CA A:LYS324 4.0 47.9 1.0 CE A:LYS324 4.1 45.7 1.0 OG1 A:THR325 4.2 45.8 1.0 CB A:THR325 4.2 45.6 1.0 C A:LYS324 4.3 46.0 1.0 CB A:ALA153 4.4 44.6 1.0 CA A:THR325 4.4 45.0 1.0 SD A:MET316 4.4 51.6 1.0 O A:GLY323 4.4 55.3 1.0 CG A:LYS324 4.6 46.1 1.0 O A:THR325 4.6 43.1 1.0 CB A:LYS324 4.8 48.2 1.0 C A:VAL46 4.9 45.6 1.0 CB A:MET316 5.0 44.6 1.0 CD A:PRO48 5.0 49.3 1.0

Chlorine binding site 3 out of 22 in the Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl411 b:31.4 occ:1.00 N A:VAL77 3.9 35.5 1.0 CA A:ASN76 3.9 35.5 1.0 OD1 A:ASN76 3.9 36.1 1.0 O A:LYS75 4.0 33.1 1.0 CA A:GLY35 4.1 44.6 1.0 CG A:ASN76 4.3 34.3 1.0 CG2 A:VAL77 4.4 39.5 1.0 C A:ASN76 4.4 36.0 1.0 CB A:ASN76 4.6 34.0 1.0 N A:GLY35 4.6 45.4 1.0 C A:LYS75 4.8 36.2 1.0 CG1 A:VAL77 4.8 34.8 1.0 N A:ASN76 4.9 35.4 1.0 CB A:VAL77 4.9 39.1 1.0 CA A:VAL77 5.0 38.0 1.0

Chlorine binding site 4 out of 22 in the Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl413 b:60.2 occ:1.00 N A:GLY82 3.8 40.6 1.0 O A:VAL71 3.8 39.5 1.0 CA A:GLY82 4.0 41.8 1.0 CD A:LYS70 4.2 45.1 1.0 CA A:VAL72 4.4 43.2 1.0 CB A:LYS81 4.4 41.8 1.0 C A:LYS81 4.5 41.5 1.0 CG A:LYS70 4.6 42.8 1.0 O A:VAL72 4.8 45.7 1.0 CG1 A:VAL72 4.8 40.9 1.0 CD A:LYS81 4.8 39.5 1.0 C A:VAL71 4.8 40.0 1.0 CA A:LYS81 4.8 41.1 1.0 CG A:LYS81 5.0 44.3 1.0

Chlorine binding site 5 out of 22 in the Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl422 b:18.6 occ:1.00 CA A:ALA149 3.7 45.7 1.0 CD A:LYS178 3.8 47.9 1.0 N A:GLY174 3.8 46.1 1.0 NZ A:LYS178 3.9 58.7 1.0 C A:ALA149 3.9 44.5 1.0 N A:ALA151 3.9 46.5 1.0 CA A:VAL173 4.0 45.8 1.0 N A:ALA150 4.0 42.2 1.0 CE A:LYS178 4.2 54.5 1.0 CB A:ALA151 4.2 48.0 1.0 N A:GLY152 4.3 47.6 1.0 CG2 A:VAL173 4.3 39.7 1.0 CB A:ALA149 4.4 45.8 1.0 C A:VAL173 4.4 44.3 1.0 CA A:ALA151 4.4 48.6 1.0 O A:ALA149 4.4 47.8 1.0 C A:ALA151 4.5 49.5 1.0 O A:ALA172 4.6 40.7 1.0 CB A:VAL173 4.7 44.2 1.0 CA A:GLY174 4.8 47.8 1.0 N A:ALA149 4.9 49.1 1.0 CG A:LYS178 5.0 48.0 1.0 C A:ALA150 5.0 43.5 1.0

Chlorine binding site 6 out of 22 in the Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl402 b:28.4 occ:1.00 CD2 B:TYR193 3.2 71.8 1.0 CE2 B:TYR193 3.4 68.9 1.0 O B:ALA172 3.7 42.5 1.0 N B:ALA149 3.7 47.6 1.0 CG B:TYR193 3.9 63.1 1.0 C B:ALA172 3.9 42.2 1.0 CB B:ALA172 4.1 36.5 1.0 N B:VAL173 4.1 43.0 1.0 CZ B:TYR193 4.3 70.0 1.0 CA B:ALA149 4.3 44.8 1.0 CG1 B:VAL218 4.4 43.5 1.0 CB B:ASN148 4.4 44.9 1.0 C B:VAL173 4.4 46.3 1.0 CA B:VAL173 4.4 45.2 1.0 CB B:TYR193 4.5 57.9 1.0 O B:VAL173 4.5 47.6 1.0 CE1 B:PHE222 4.6 57.0 1.0 CD1 B:TYR193 4.6 67.8 1.0 CA B:ALA172 4.7 41.2 1.0 C B:ASN148 4.7 46.7 1.0 CA B:ASN148 4.7 45.7 1.0 CE1 B:TYR193 4.8 69.0 1.0 CD1 B:PHE222 4.9 58.4 1.0 N B:GLY174 4.9 47.5 1.0

Chlorine binding site 7 out of 22 in the Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl409 b:39.6 occ:1.00 NZ B:LYS324 3.5 46.8 1.0 N B:THR325 3.6 46.7 1.0 O B:VAL46 3.6 43.8 1.0 CG B:MET316 3.7 48.2 1.0 CD B:LYS324 3.9 40.1 1.0 OG1 B:THR325 3.9 48.9 1.0 CB B:THR325 4.1 45.3 1.0 CE B:LYS324 4.1 41.6 1.0 CA B:LYS324 4.2 46.3 1.0 CA B:THR325 4.4 45.2 1.0 C B:LYS324 4.4 45.6 1.0 CB B:ALA153 4.5 49.5 1.0 CG B:LYS324 4.7 42.8 1.0 O B:THR325 4.8 39.1 1.0 O B:GLY323 4.8 56.0 1.0 O B:HOH485 4.8 42.2 1.0 SD B:MET316 4.8 55.2 1.0 CD B:PRO48 4.8 49.7 1.0 C B:VAL46 4.8 43.4 1.0 CB B:MET316 4.8 46.4 1.0 CB B:LYS324 4.9 47.5 1.0 OD2 B:ASP47 4.9 63.8 1.0

Chlorine binding site 8 out of 22 in the Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl412 b:37.6 occ:1.00 N B:VAL77 3.8 38.1 1.0 CA B:ASN76 3.9 35.7 1.0 OD1 B:ASN76 3.9 46.9 1.0 CG2 B:VAL77 4.1 39.1 1.0 O B:LYS75 4.2 35.7 1.0 CG B:ASN76 4.2 37.4 1.0 CA B:GLY35 4.2 44.7 1.0 C B:ASN76 4.3 36.6 1.0 CB B:ASN76 4.5 37.1 1.0 ND2 B:ASN76 4.7 39.2 1.0 N B:GLY35 4.8 45.5 1.0 N B:ASN76 4.8 35.5 1.0 CB B:VAL77 4.8 39.0 1.0 CA B:VAL77 4.9 40.2 1.0 CG1 B:VAL77 4.9 38.5 1.0 C B:LYS75 4.9 37.9 1.0

Chlorine binding site 9 out of 22 in the Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl418 b:58.8 occ:1.00 N B:GLY82 3.9 40.5 1.0 O B:VAL71 4.0 39.0 1.0 CA B:GLY82 4.1 41.5 1.0 CD B:LYS70 4.4 42.3 1.0 CA B:VAL72 4.5 43.9 1.0 CG1 B:VAL72 4.5 45.1 1.0 C B:LYS81 4.6 41.5 1.0 CB B:LYS81 4.7 42.3 1.0 CG B:LYS70 4.8 41.1 1.0 CB B:VAL72 4.9 44.2 1.0 CG B:LYS81 4.9 43.5 1.0 CD B:LYS81 5.0 45.4 1.0 O B:VAL72 5.0 49.1 1.0

Chlorine binding site 10 out of 22 in the Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Crystal Structure of Human Nadp-Dependent Leukotriene B4 12- Hydroxydehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl420 b:19.2 occ:1.00 N B:GLY174 3.8 47.5 1.0 CA B:ALA149 3.8 44.8 1.0 N B:ALA151 3.9 46.3 1.0 C B:ALA149 3.9 42.6 1.0 NZ B:LYS178 3.9 57.6 1.0 CD B:LYS178 3.9 49.3 1.0 CA B:VAL173 4.0 45.2 1.0 N B:ALA150 4.0 41.2 1.0 CB B:ALA151 4.1 49.0 1.0 CG2 B:VAL173 4.2 35.4 1.0 N B:GLY152 4.2 49.0 1.0 O B:ALA149 4.4 43.4 1.0 C B:VAL173 4.4 46.3 1.0 CA B:ALA151 4.4 48.6 1.0 CE B:LYS178 4.4 51.8 1.0 C B:ALA151 4.4 49.3 1.0 CB B:VAL173 4.5 42.7 1.0 O B:ALA172 4.5 42.5 1.0 CB B:ALA149 4.5 46.5 1.0 CG1 B:VAL173 4.8 46.5 1.0 CA B:GLY174 4.8 49.0 1.0 N B:ALA149 4.9 47.6 1.0 C B:ALA150 5.0 44.9 1.0 CA B:GLY152 5.0 46.3 1.0

A.P.Turnbull, C.Johansson, P.Savitsky, K.Guo, A.Edwards, C.Arrowsmith, M.Sundstrom, F.Von Delft, U.Oppermann. Crystal Structure of Human Nadp-Dependent Leukotriene B4 12-Hydroxydehydrogenase To Be Published.