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Atomistry » Chlorine » PDB 1zop-232l » 1zxv | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 1zop-232l » 1zxv » |
Chlorine in PDB 1zxv: X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to A Small Molecule Inhibitor, Bi-MFM3, 3-{5-[5-(4-Chloro- Phenyl)-Furan-2-Ylmethylene]-4-Oxo-2-Thioxo-Thiazolidin-3- Yl}-Propionic Acid.Enzymatic activity of X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to A Small Molecule Inhibitor, Bi-MFM3, 3-{5-[5-(4-Chloro- Phenyl)-Furan-2-Ylmethylene]-4-Oxo-2-Thioxo-Thiazolidin-3- Yl}-Propionic Acid.
All present enzymatic activity of X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to A Small Molecule Inhibitor, Bi-MFM3, 3-{5-[5-(4-Chloro- Phenyl)-Furan-2-Ylmethylene]-4-Oxo-2-Thioxo-Thiazolidin-3- Yl}-Propionic Acid.:
3.4.24.83; Protein crystallography data
The structure of X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to A Small Molecule Inhibitor, Bi-MFM3, 3-{5-[5-(4-Chloro- Phenyl)-Furan-2-Ylmethylene]-4-Oxo-2-Thioxo-Thiazolidin-3- Yl}-Propionic Acid., PDB code: 1zxv
was solved by
T.Y.Wong,
R.C.Liddington,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 1zxv:
The structure of X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to A Small Molecule Inhibitor, Bi-MFM3, 3-{5-[5-(4-Chloro- Phenyl)-Furan-2-Ylmethylene]-4-Oxo-2-Thioxo-Thiazolidin-3- Yl}-Propionic Acid. also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to A Small Molecule Inhibitor, Bi-MFM3, 3-{5-[5-(4-Chloro- Phenyl)-Furan-2-Ylmethylene]-4-Oxo-2-Thioxo-Thiazolidin-3- Yl}-Propionic Acid.
(pdb code 1zxv). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to A Small Molecule Inhibitor, Bi-MFM3, 3-{5-[5-(4-Chloro- Phenyl)-Furan-2-Ylmethylene]-4-Oxo-2-Thioxo-Thiazolidin-3- Yl}-Propionic Acid., PDB code: 1zxv: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 1zxvGo back to![]() ![]()
Chlorine binding site 1 out
of 2 in the X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to A Small Molecule Inhibitor, Bi-MFM3, 3-{5-[5-(4-Chloro- Phenyl)-Furan-2-Ylmethylene]-4-Oxo-2-Thioxo-Thiazolidin-3- Yl}-Propionic Acid.
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 2 in 1zxvGo back to![]() ![]()
Chlorine binding site 2 out
of 2 in the X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to A Small Molecule Inhibitor, Bi-MFM3, 3-{5-[5-(4-Chloro- Phenyl)-Furan-2-Ylmethylene]-4-Oxo-2-Thioxo-Thiazolidin-3- Yl}-Propionic Acid.
![]() Mono view ![]() Stereo pair view
Reference:
M.Forino,
S.Johnson,
T.Y.Wong,
D.V.Rozanov,
A.Y.Savinov,
W.Li,
R.Fattorusso,
B.Becattini,
A.J.Orry,
D.Jung,
R.A.Abagyan,
J.W.Smith,
K.Alibek,
R.C.Liddington,
A.Y.Strongin,
M.Pellecchia.
Efficient Synthetic Inhibitors of Anthrax Lethal Factor. Proc.Natl.Acad.Sci.Usa V. 102 9499 2005.
Page generated: Sat Jul 20 04:53:53 2024
ISSN: ISSN 0027-8424 PubMed: 15983377 DOI: 10.1073/PNAS.0502733102 |
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