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PDB 2a72-2aiq »
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Chlorine in PDB 2abj: Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate.
Enzymatic activity of Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate.
All present enzymatic activity of Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate.:
2.6.1.42;
2.6.1.42;
Protein crystallography data
The structure of Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate., PDB code: 2abj
was solved by
J.F.Ohren,
D.W.Moreland,
J.R.Rubin,
H.L.Hu,
P.C.Mcconnell,
A.Mistry,
W.T.Mueller,
J.D.Scholten,
C.H.Hasemann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 90.91 / 2.20 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 110.327, 114.517, 148.869, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 20.5 / 25.7 |
Other elements in 2abj:
The structure of Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate. also contains other interesting chemical elements:
| Fluorine | (F) | 12 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate.
(pdb code 2abj). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate., PDB code: 2abj:
Jump to Chlorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate., PDB code: 2abj:
Jump to Chlorine binding site number: 1; 2; 3; 4;
Chlorine binding site 1 out of 4 in 2abj
Go back to
Chlorine Binding Sites List in 2abj
Chlorine binding site 1 out
of 4 in the Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate. within 5.0Å range:
|
Chlorine binding site 2 out of 4 in 2abj
Go back to
Chlorine Binding Sites List in 2abj
Chlorine binding site 2 out
of 4 in the Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate. within 5.0Å range:
|
Chlorine binding site 3 out of 4 in 2abj
Go back to
Chlorine Binding Sites List in 2abj
Chlorine binding site 3 out
of 4 in the Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate. within 5.0Å range:
|
Chlorine binding site 4 out of 4 in 2abj
Go back to
Chlorine Binding Sites List in 2abj
Chlorine binding site 4 out
of 4 in the Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Crystal Structure of Human Branched Chain Amino Acid Transaminase in A Complex with An Inhibitor, C16H10N2O4F3SCL, and Pyridoxal 5' Phosphate. within 5.0Å range:
|
Reference:
L.Y.Hu,
P.A.Boxer,
S.R.Kesten,
H.J.Lei,
D.J.Wustrow,
D.W.Moreland,
L.Zhang,
K.Ahn,
T.R.Ryder,
X.Liu,
J.R.Rubin,
K.Fahnoe,
R.T.Carroll,
S.Dutta,
D.C.Fahnoe,
A.W.Probert,
R.L.Roof,
M.F.Rafferty,
C.R.Kostlan,
J.D.Scholten,
M.Hood,
X.D.Ren,
G.P.Schielke,
T.Z.Su,
C.P.Taylor,
A.Mistry,
P.Mcconnell,
C.Hasemann,
J.Ohren.
The Design and Synthesis of Human Branched-Chain Amino Acid Aminotransferase Inhibitors For Treatment of Neurodegenerative Diseases. Bioorg.Med.Chem.Lett. V. 16 2337 2006.
ISSN: ISSN 0960-894X
PubMed: 16143519
DOI: 10.1016/J.BMCL.2005.07.058
Page generated: Sat Jul 20 05:11:40 2024
ISSN: ISSN 0960-894X
PubMed: 16143519
DOI: 10.1016/J.BMCL.2005.07.058
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