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Chlorine in PDB 2buf: Arginine Feed-Back Inhibitable Acetylglutamate Kinase

Enzymatic activity of Arginine Feed-Back Inhibitable Acetylglutamate Kinase

All present enzymatic activity of Arginine Feed-Back Inhibitable Acetylglutamate Kinase:
2.7.2.8;

Protein crystallography data

The structure of Arginine Feed-Back Inhibitable Acetylglutamate Kinase, PDB code: 2buf was solved by S.Ramon-Maiques, M.L.Fernandez-Murga, A.Vagin, I.Fita, V.Rubio, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 18.00 / 2.95
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 71.860, 98.780, 162.900, 91.49, 92.03, 107.56
R / Rfree (%) 24.9 / 26.7

Other elements in 2buf:

The structure of Arginine Feed-Back Inhibitable Acetylglutamate Kinase also contains other interesting chemical elements:

Magnesium (Mg) 8 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Arginine Feed-Back Inhibitable Acetylglutamate Kinase (pdb code 2buf). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Arginine Feed-Back Inhibitable Acetylglutamate Kinase, PDB code: 2buf:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in 2buf

Go back to Chlorine Binding Sites List in 2buf
Chlorine binding site 1 out of 6 in the Arginine Feed-Back Inhibitable Acetylglutamate Kinase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Arginine Feed-Back Inhibitable Acetylglutamate Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1303

b:82.3
occ:1.00
 OH B:TYR249 4.0 63.3 1.0
CZ B:TYR249 4.9 62.2 1.0
SD B:MET224 4.9 72.9 1.0
CE2 B:TYR249 4.9 61.9 1.0
C4 B:ADP1300 5.0 72.4 1.0
CD1 B:ILE220 5.0 69.4 1.0

Chlorine binding site 2 out of 6 in 2buf

Go back to Chlorine Binding Sites List in 2buf
Chlorine binding site 2 out of 6 in the Arginine Feed-Back Inhibitable Acetylglutamate Kinase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Arginine Feed-Back Inhibitable Acetylglutamate Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1302

b:84.2
occ:1.00
 OH C:TYR249 3.7 48.0 1.0
CE C:MET224 3.8 76.8 1.0
CZ C:TYR249 4.7 48.2 1.0
CE2 C:TYR249 4.7 47.6 1.0

Chlorine binding site 3 out of 6 in 2buf

Go back to Chlorine Binding Sites List in 2buf
Chlorine binding site 3 out of 6 in the Arginine Feed-Back Inhibitable Acetylglutamate Kinase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Arginine Feed-Back Inhibitable Acetylglutamate Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1303

b:86.8
occ:1.00
 OH D:TYR249 3.9 53.7 1.0
C5 D:ADP1300 4.4 44.6 1.0
C4 D:ADP1300 4.5 45.2 1.0
N7 D:ADP1300 4.5 45.1 1.0
CZ D:TYR249 4.6 54.6 1.0
N9 D:ADP1300 4.6 46.2 1.0
C8 D:ADP1300 4.7 43.6 1.0
CE2 D:TYR249 4.7 53.7 1.0
C6 D:ADP1300 4.7 43.6 1.0
CD1 D:ILE220 4.8 50.4 1.0
C2' D:ADP1300 4.8 48.0 1.0
N3 D:ADP1300 4.9 45.1 1.0

Chlorine binding site 4 out of 6 in 2buf

Go back to Chlorine Binding Sites List in 2buf
Chlorine binding site 4 out of 6 in the Arginine Feed-Back Inhibitable Acetylglutamate Kinase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Arginine Feed-Back Inhibitable Acetylglutamate Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Cl1302

b:92.5
occ:1.00
 OH G:TYR249 3.7 91.7 1.0
CE G:MET224 4.6 92.4 1.0
CZ G:TYR249 4.7 92.0 1.0
C5 G:ADP1299 4.8 84.7 1.0
C6 G:ADP1299 4.8 84.5 1.0
CB G:MET224 4.9 85.4 1.0
O G:ASP225 5.0 84.8 1.0
C4 G:ADP1299 5.0 85.0 1.0

Chlorine binding site 5 out of 6 in 2buf

Go back to Chlorine Binding Sites List in 2buf
Chlorine binding site 5 out of 6 in the Arginine Feed-Back Inhibitable Acetylglutamate Kinase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Arginine Feed-Back Inhibitable Acetylglutamate Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Cl1300

b:97.5
occ:1.00
 OH H:TYR249 3.9 0.3 1.0
CZ H:TYR249 4.5 0.6 1.0
C5 H:ADP1297 4.7 0.3 0.5
C6 H:ADP1297 4.7 0.2 0.5
N7 H:ADP1297 4.7 0.2 0.5
N6 H:ADP1297 4.8 0.2 0.5
CE2 H:TYR249 4.9 0.5 1.0
O H:ASP225 4.9 0.5 1.0
O H:MET224 5.0 0.4 1.0

Chlorine binding site 6 out of 6 in 2buf

Go back to Chlorine Binding Sites List in 2buf
Chlorine binding site 6 out of 6 in the Arginine Feed-Back Inhibitable Acetylglutamate Kinase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Arginine Feed-Back Inhibitable Acetylglutamate Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Cl1303

b:0.1
occ:1.00
 CE L:MET224 3.5 91.3 1.0
CD1 L:ILE220 4.2 76.6 1.0
OH L:TYR249 4.2 90.8 1.0
C2 L:ADP1300 4.7 70.0 1.0
N3 L:ADP1300 4.7 70.4 1.0
N1 L:ADP1300 4.8 68.9 1.0
C4 L:ADP1300 4.8 70.8 1.0
C5 L:ADP1300 4.9 70.0 1.0
C6 L:ADP1300 4.9 69.7 1.0
SD L:MET224 5.0 88.6 1.0

Reference:

S.Ramon-Maiques, M.L.Fernandez-Murga, F.Gil-Ortiz, A.Vagin, I.Fita, V.Rubio. Structural Bases of Feed-Back Control of Arginine Biosynthesis, Revealed By the Structure of Two Hexameric N-Acetylglutamate Kinases, From Thermotoga Maritima and Pseudomonas Aeruginosa J.Mol.Biol. V. 356 695 2006.
ISSN: ISSN 0022-2836
PubMed: 16376937
DOI: 10.1016/J.JMB.2005.11.079
Page generated: Sat Jul 20 05:55:08 2024

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