Chlorine in PDB 2buj: Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine

All present enzymatic activity of Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine:
2.7.1.37;

The structure of Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine, PDB code: 2buj was solved by J.E.Debreczeni, J.Eswaran, A.Bullock, P.Filippakopoulos, K.Kavanagh, A.Amos, O.Fedorov, F.Sobott, L.J.Ball, F.Von Delft, C.Arrowsmith, M.Sundstrom, A.Edwards, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	64.82 / 2.60
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	104.554, 168.901, 129.729, 90.00, 90.00, 90.00
R / Rfree (%)	18.5 / 22.9

The binding sites of Chlorine atom in the Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine (pdb code 2buj). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine, PDB code: 2buj:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1300 b:65.3 occ:1.00 N4 A:STU1302 3.3 53.4 1.0 NH1 A:ARG59 3.5 49.4 1.0 NH2 A:ARG59 3.7 45.9 1.0 C23 A:STU1302 3.7 52.1 1.0 C24 A:STU1302 3.7 46.5 1.0 C28 A:STU1302 3.8 54.0 1.0 CZ A:ARG59 4.1 43.0 1.0 C25 A:STU1302 5.0 36.6 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1298 b:63.6 occ:1.00 N B:GLY30 3.3 36.1 1.0 OG B:SER32 3.7 32.0 1.0 NZ B:LYS49 3.9 29.1 1.0 CE B:LYS49 4.0 27.3 1.0 CA B:GLY29 4.1 36.6 1.0 C B:GLY29 4.2 37.6 1.0 CA B:GLY30 4.2 35.6 1.0 CB B:SER32 4.5 28.5 1.0 N B:PHE31 4.5 40.2 1.0 C B:GLY30 4.9 38.9 1.0

J.E.Debreczeni, J.Eswaran, A.Bullock, P.Filippakopoulos, K.Kavanagh, A.Amos, O.Fedorov, F.Sobott, L.J.Ball, F.Von Delft, C.Arrowsmith, M.Sundstrom, A.Edwards, S.Knapp. Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine To Be Published.