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Chlorine in PDB 2c16: 5-(4-Carboxy-2-Oxo-Butane-1-Sulfinyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa

Enzymatic activity of 5-(4-Carboxy-2-Oxo-Butane-1-Sulfinyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa

All present enzymatic activity of 5-(4-Carboxy-2-Oxo-Butane-1-Sulfinyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa:
4.2.1.24;

Protein crystallography data

The structure of 5-(4-Carboxy-2-Oxo-Butane-1-Sulfinyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa, PDB code: 2c16 was solved by F.Frere, M.Nentwich, S.Gacond, D.W.Heinz, R.Neier, N.Frankenberg-Dinkel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 89.80 / 2.02
Space group P 4 21 2
Cell size a, b, c (Å), α, β, γ (°) 125.513, 125.513, 86.765, 90.00, 90.00, 90.00
R / Rfree (%) 14.3 / 18.3

Other elements in 2c16:

The structure of 5-(4-Carboxy-2-Oxo-Butane-1-Sulfinyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the 5-(4-Carboxy-2-Oxo-Butane-1-Sulfinyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa (pdb code 2c16). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the 5-(4-Carboxy-2-Oxo-Butane-1-Sulfinyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa, PDB code: 2c16:

Chlorine binding site 1 out of 1 in 2c16

Go back to Chlorine Binding Sites List in 2c16
Chlorine binding site 1 out of 1 in the 5-(4-Carboxy-2-Oxo-Butane-1-Sulfinyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of 5-(4-Carboxy-2-Oxo-Butane-1-Sulfinyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1337

b:24.4
occ:1.00
 N B:ASN196 3.1 14.8 1.0
O B:HOH2237 3.2 16.7 0.5
O B:HOH2240 3.2 23.6 1.0
C B:HIS194 3.5 15.2 0.5
N B:THR195 3.6 14.9 0.5
C B:HIS194 3.6 15.0 0.5
CA B:ASN196 3.7 15.3 1.0
N B:THR195 3.7 15.2 0.5
N B:VAL197 3.7 13.4 1.0
CA B:HIS194 3.7 14.8 0.5
CB B:ASN196 3.7 15.8 1.0
CA B:HIS194 3.7 15.0 0.5
C B:ASN196 3.9 14.3 1.0
O B:HIS194 3.9 14.7 0.5
CG2 B:VAL197 4.0 12.9 1.0
O B:HIS194 4.2 14.6 0.5
C B:THR195 4.2 15.1 0.5
C B:THR195 4.2 14.8 0.5
CB B:HIS194 4.3 14.9 0.5
CB B:HIS194 4.4 15.0 0.5
CA B:THR195 4.4 14.4 0.5
CA B:THR195 4.4 15.1 0.5
O B:GLY193 4.5 17.2 1.0
OG1 B:THR195 4.5 14.6 0.5
ND1 B:HIS194 4.6 15.2 0.5
ND2 B:ASN196 4.6 17.2 1.0
CG B:ASN196 4.6 18.6 1.0
CA B:VAL197 4.7 12.9 1.0
O B:HOH2221 4.7 5.5 0.5
O B:HOH2214 4.7 16.6 0.5
O B:ASN196 4.8 14.4 1.0
CB B:VAL197 4.8 12.7 1.0
CG B:HIS194 4.9 15.9 0.5
N B:HIS194 4.9 15.6 0.5
N B:HIS194 4.9 15.6 0.5
CB B:THR195 5.0 15.5 0.5

Reference:

F.Frere, M.Nentwich, S.Gacond, D.W.Heinz, R.Neier, N.Frankenberg-Dinkel. Probing the Active Site of Pseudomonas Aeruginosa Porphobilinogen Synthase Using Newly Developed Inhibitors. Biochemistry V. 45 8243 2006.
ISSN: ISSN 0006-2960
PubMed: 16819823
DOI: 10.1021/BI052611F
Page generated: Sat Jul 20 06:03:04 2024

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