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Atomistry » Chlorine » PDB 2bwv-2c5h » 2c1b | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 2bwv-2c5h » 2c1b » |
Chlorine in PDB 2c1b: Structure of Camp-Dependent Protein Kinase Complexed with (4R,2S)-5'- (4-(4-Chlorobenzyloxy)Pyrrolidin-2-Ylmethanesulfonyl)IsoquinolineEnzymatic activity of Structure of Camp-Dependent Protein Kinase Complexed with (4R,2S)-5'- (4-(4-Chlorobenzyloxy)Pyrrolidin-2-Ylmethanesulfonyl)Isoquinoline
All present enzymatic activity of Structure of Camp-Dependent Protein Kinase Complexed with (4R,2S)-5'- (4-(4-Chlorobenzyloxy)Pyrrolidin-2-Ylmethanesulfonyl)Isoquinoline:
2.7.1.37; Protein crystallography data
The structure of Structure of Camp-Dependent Protein Kinase Complexed with (4R,2S)-5'- (4-(4-Chlorobenzyloxy)Pyrrolidin-2-Ylmethanesulfonyl)Isoquinoline, PDB code: 2c1b
was solved by
I.Collins,
J.Caldwell,
T.Fonseca,
A.Donald,
V.Bavetsias,
L.J.Hunter,
M.D.Garrett,
M.G.Rowlands,
G.W.Aherne,
T.G.Davies,
V.Berdini,
S.J.Woodhead,
L.C.A.Seavers,
P.G.Wyatt,
P.Workman,
E.Mcdonald,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of Camp-Dependent Protein Kinase Complexed with (4R,2S)-5'- (4-(4-Chlorobenzyloxy)Pyrrolidin-2-Ylmethanesulfonyl)Isoquinoline
(pdb code 2c1b). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Camp-Dependent Protein Kinase Complexed with (4R,2S)-5'- (4-(4-Chlorobenzyloxy)Pyrrolidin-2-Ylmethanesulfonyl)Isoquinoline, PDB code: 2c1b: Chlorine binding site 1 out of 1 in 2c1bGo back to Chlorine Binding Sites List in 2c1b
Chlorine binding site 1 out
of 1 in the Structure of Camp-Dependent Protein Kinase Complexed with (4R,2S)-5'- (4-(4-Chlorobenzyloxy)Pyrrolidin-2-Ylmethanesulfonyl)Isoquinoline
Mono view Stereo pair view
Reference:
I.Collins,
J.Caldwell,
T.Fonseca,
A.Donald,
V.Bavetsias,
L.J.Hunter,
M.D.Garrett,
M.G.Rowlands,
G.W.Aherne,
T.G.Davies,
V.Berdini,
S.J.Woodhead,
D.Davis,
L.C.Seavers,
P.G.Wyatt,
P.Workman,
E.Mcdonald.
Structure-Based Design of Isoquinoline-5-Sulfonamide Inhibitors of Protein Kinase B. Bioorg. Med. Chem. V. 14 1255 2006.
Page generated: Sat Dec 12 09:01:28 2020
ISSN: ISSN 0968-0896 PubMed: 16249095 DOI: 10.1016/J.BMC.2005.09.055 |
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