Chlorine in PDB 2c30: Crystal Structure of the Human P21-Activated Kinase 6

All present enzymatic activity of Crystal Structure of the Human P21-Activated Kinase 6:
2.7.1.37;

The structure of Crystal Structure of the Human P21-Activated Kinase 6, PDB code: 2c30 was solved by P.Filippakopoulos, G.Berridge, J.Bray, N.Burgess, S.Colebrook, S.Das, J.Eswaran, O.Gileadi, E.Papagrigoriou, P.Savitsky, C.Smee, A.Turnbull, M.Sundstrom, C.Arrowsmith, J.Weigelt, A.Edwards, F.Von Delft, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	54.96 / 1.60
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	59.781, 66.674, 96.999, 90.00, 90.00, 90.00
R / Rfree (%)	19.7 / 22.2

The binding sites of Chlorine atom in the Crystal Structure of the Human P21-Activated Kinase 6 (pdb code 2c30). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Human P21-Activated Kinase 6, PDB code: 2c30:

Chlorine binding site 1 out of 1 in the Crystal Structure of the Human P21-Activated Kinase 6


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Human P21-Activated Kinase 6 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1676 b:30.8 occ:1.00 N A:GLN485 3.0 25.5 1.0 N A:LEU536 3.5 20.9 1.0 CB A:THR535 3.6 20.4 1.0 CA A:THR535 3.7 20.4 1.0 CA A:LEU484 3.8 26.2 1.0 CB A:GLN485 3.8 26.0 1.0 CA A:GLN485 3.9 25.9 1.0 C A:LEU484 3.9 26.3 1.0 CG2 A:THR535 4.0 20.5 1.0 C A:THR535 4.1 20.7 1.0 CG A:GLN485 4.3 28.1 1.0 CG A:LEU536 4.4 23.5 1.0 CB A:LEU536 4.4 22.1 1.0 N A:GLY486 4.4 25.2 1.0 CB A:LEU484 4.4 26.8 1.0 C A:GLN485 4.5 25.1 1.0 CA A:LEU536 4.6 21.7 1.0 O A:PHE483 4.6 24.5 1.0 NE2 A:GLN485 4.8 28.4 1.0 O A:LEU534 4.8 23.2 1.0 NH2 A:ARG539 4.8 30.8 0.7 CD1 A:LEU536 4.9 26.9 1.0 OG1 A:THR535 4.9 21.7 1.0 N A:THR535 5.0 21.9 1.0 CG A:LEU484 5.0 28.6 1.0

J.Eswaran, W.H.Lee, J.E.Debreczeni, P.Filippakopoulos, A.Turnbull, O.Fedorov, S.W.Deacon, J.R.Peterson, S.Knapp. Crystal Structures of the P21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II Paks. Structure V. 15 201 2007.
ISSN: ISSN 0969-2126
PubMed: 17292838
DOI: 10.1016/J.STR.2007.01.001