Chlorine in PDB 2c36: Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor- Mediated Activation of Virus Entry

The structure of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor- Mediated Activation of Virus Entry, PDB code: 2c36 was solved by C.Krummenacher, V.M.Supekar, J.C.Whitbeck, E.Lazear, S.A.Connolly, R.J.Eisenberg, G.H.Cohen, D.C.Wiley, A.Carfi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	81.65 / 2.11
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	74.252, 106.193, 130.315, 90.00, 90.00, 90.00
R / Rfree (%)	19.4 / 24.7

The structure of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor- Mediated Activation of Virus Entry also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Chlorine atom in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor- Mediated Activation of Virus Entry (pdb code 2c36). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor- Mediated Activation of Virus Entry, PDB code: 2c36:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor- Mediated Activation of Virus Entry


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor- Mediated Activation of Virus Entry within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1312 b:41.0 occ:1.00 O A:HOH2004 3.2 44.0 1.0 N A:ILE224 3.3 36.9 1.0 ND2 A:ASN227 3.3 35.1 1.0 NE2 A:GLN27 3.4 39.5 1.0 CB A:PHE223 3.5 37.3 1.0 CA A:PHE223 3.5 36.8 1.0 CD2 A:PHE223 3.9 38.8 1.0 C A:PHE223 3.9 36.6 1.0 CG2 A:ILE224 4.0 37.8 1.0 CG1 A:ILE224 4.1 36.0 1.0 CG A:PHE223 4.2 37.8 1.0 CB A:ASN227 4.3 36.7 1.0 CG A:ASN227 4.3 37.8 1.0 CG A:GLN27 4.3 47.2 1.0 CD A:GLN27 4.3 44.0 1.0 CB A:ILE224 4.4 37.8 1.0 CA A:ILE224 4.4 37.1 1.0 CD1 A:ILE224 4.5 38.0 1.0 O A:LEU28 4.5 49.0 1.0 O A:HOH2205 4.7 42.1 1.0 O A:HOH2133 4.8 60.8 1.0 N A:PHE223 4.8 36.4 1.0

Chlorine binding site 2 out of 3 in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor- Mediated Activation of Virus Entry


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor- Mediated Activation of Virus Entry within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1313 b:38.4 occ:1.00 O A:HOH2248 3.2 38.7 1.0 NZ A:LYS245 3.2 36.2 1.0 CE A:LYS245 3.9 38.0 1.0 CB A:ASP272 4.0 42.0 1.0 CD A:LYS245 4.1 38.1 1.0 NH1 A:ARG67 4.7 43.6 1.0 OD2 A:ASP272 4.8 40.0 1.0 OD2 A:ASP275 4.8 36.8 1.0 N A:ASP272 4.8 43.6 1.0 CB A:GLU271 4.9 47.2 1.0 CG A:ASP272 4.9 41.1 1.0

Chlorine binding site 3 out of 3 in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor- Mediated Activation of Virus Entry


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor- Mediated Activation of Virus Entry within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1314 b:37.6 occ:1.00 O B:HOH2001 3.1 46.2 1.0 O B:HOH2226 3.1 62.1 1.0 ND2 B:ASN227 3.2 35.2 1.0 NE2 B:GLN27 3.3 36.8 1.0 N B:ILE224 3.4 36.9 1.0 CA B:PHE223 3.5 36.4 1.0 CB B:PHE223 3.5 36.7 1.0 CD2 B:PHE223 3.9 38.0 1.0 C B:PHE223 4.0 36.5 1.0 CG1 B:ILE224 4.0 37.2 1.0 CG2 B:ILE224 4.1 37.6 1.0 CG B:PHE223 4.2 37.3 1.0 CG B:ASN227 4.2 38.0 1.0 CD B:GLN27 4.3 42.4 1.0 CB B:ASN227 4.3 37.6 1.0 CG B:GLN27 4.3 44.8 1.0 CB B:ILE224 4.4 37.4 1.0 CA B:ILE224 4.5 37.1 1.0 O B:LEU28 4.5 47.1 1.0 O B:HOH2180 4.7 37.9 1.0 CD1 B:ILE224 4.8 39.3 1.0 N B:PHE223 4.8 35.0 1.0

C.Krummenacher, V.M.Supekar, J.C.Whitbeck, E.Lazear, S.A.Connolly, R.J.Eisenberg, G.H.Cohen, D.C.Wiley, A.Carfi. Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry. Embo J. V. 24 4144 2005.
ISSN: ISSN 0261-4189
PubMed: 16292345
DOI: 10.1038/SJ.EMBOJ.7600875