Chlorine in PDB 2c3a: Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry

The structure of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry, PDB code: 2c3a was solved by C.Krummenacher, V.M.Supekar, J.C.Whitbeck, E.Lazear, S.A.Connolly, R.J.Eisenberg, G.H.Cohen, D.C.Wiley, A.Carfi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.00 / 2.5
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	67.629, 79.105, 123.563, 90.00, 90.00, 90.00
R / Rfree (%)	22.6 / 27.5

The structure of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry also contains other interesting chemical elements:

Zinc	(Zn)	5 atoms
Sodium	(Na)	2 atoms

The binding sites of Chlorine atom in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry (pdb code 2c3a). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry, PDB code: 2c3a:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1309 b:42.0 occ:1.00 ND2 A:ASN227 3.2 46.9 1.0 OE1 A:GLN27 3.3 58.9 1.0 CG A:PRO297 3.4 46.9 1.0 N A:ILE224 3.5 40.5 1.0 CD A:PRO297 3.6 47.6 1.0 CA A:PHE223 3.7 39.0 1.0 CB A:PHE223 3.7 39.2 1.0 CD2 A:PHE223 3.8 40.3 1.0 CG1 A:ILE224 3.9 42.0 1.0 OE1 A:GLN132 4.0 36.9 1.0 CG2 A:ILE224 4.0 42.4 1.0 C A:PHE223 4.1 39.3 1.0 CG A:PHE223 4.2 39.7 1.0 CG A:ASN227 4.2 43.5 1.0 CD A:GLN27 4.2 58.8 1.0 CB A:ASN227 4.3 42.6 1.0 CB A:ILE224 4.4 41.4 1.0 NE2 A:GLN27 4.4 58.0 1.0 O A:LEU28 4.5 55.0 1.0 CA A:ILE224 4.5 41.3 1.0 CD1 A:ILE224 4.8 41.2 1.0 CB A:PRO297 4.9 46.7 1.0 O A:ARG222 4.9 38.8 1.0 N A:PRO297 4.9 47.5 1.0 N A:PHE223 4.9 38.9 1.0 CE2 A:PHE223 5.0 38.2 1.0

Chlorine binding site 2 out of 2 in the Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1310 b:29.9 occ:1.00 NE2 B:GLN27 3.2 34.6 1.0 N B:ILE224 3.5 25.7 1.0 ND2 B:ASN227 3.5 31.3 1.0 O B:HOH2001 3.5 26.4 1.0 CD2 B:PHE223 3.7 27.8 1.0 CD B:PRO297 3.7 39.8 1.0 CG B:PRO297 3.8 40.9 1.0 CA B:PHE223 3.8 25.0 1.0 CG2 B:ILE224 3.9 27.1 1.0 CB B:PHE223 3.9 25.0 1.0 CG1 B:ILE224 4.0 29.1 1.0 C B:PHE223 4.2 25.1 1.0 CD B:GLN27 4.2 36.1 1.0 NE2 B:GLN132 4.3 25.8 1.0 CG B:PHE223 4.3 25.8 1.0 CB B:ILE224 4.3 27.5 1.0 CB B:ASN227 4.4 28.8 1.0 CG B:GLN27 4.4 38.6 1.0 CG B:ASN227 4.4 30.4 1.0 O B:LEU28 4.5 40.0 1.0 CD1 B:ILE224 4.5 31.3 1.0 CA B:ILE224 4.5 26.8 1.0 CE2 B:PHE223 4.8 27.1 1.0 CB B:PRO297 4.8 40.1 1.0 O B:HIS295 4.9 39.1 1.0

C.Krummenacher, V.M.Supekar, J.C.Whitbeck, E.Lazear, S.A.Connolly, R.J.Eisenberg, G.H.Cohen, D.C.Wiley, A.Carfi. Structure of Unliganded Hsv Gd Reveals A Mechanism For Receptor-Mediated Activation of Virus Entry. Embo J. V. 24 4144 2005.
ISSN: ISSN 0261-4189
PubMed: 16292345
DOI: 10.1038/SJ.EMBOJ.7600875